ID B1Z4S6_BURA4 Unreviewed; 375 AA.
AC B1Z4S6;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Alcohol dehydrogenase zinc-binding domain protein {ECO:0000313|EMBL:ACB68739.1};
GN OrderedLocusNames=BamMC406_6306 {ECO:0000313|EMBL:ACB68739.1};
OS Burkholderia ambifaria (strain MC40-6).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=398577 {ECO:0000313|EMBL:ACB68739.1, ECO:0000313|Proteomes:UP000001680};
RN [1] {ECO:0000313|Proteomes:UP000001680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC40-6 {ECO:0000313|Proteomes:UP000001680};
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Ramette A.,
RA Konstantinidis K., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome 3 of Burkholderia ambifaria MC40-6.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:5TNX}
RP X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH ZINC.
RA Abendroth J., Mayclin S.J., Lorimer D., Edwards T.E.;
RT "Crystal structure of Alcohol dehydrogenase zinc-binding domain protein
RT from Burkholderia ambifaria.";
RL Submitted (OCT-2016) to the PDB data bank.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP001027; ACB68739.1; -; Genomic_DNA.
DR RefSeq; WP_012372624.1; NC_010557.1.
DR PDB; 5TNX; X-ray; 1.70 A; A=1-375.
DR PDBsum; 5TNX; -.
DR AlphaFoldDB; B1Z4S6; -.
DR SMR; B1Z4S6; -.
DR KEGG; bac:BamMC406_6306; -.
DR HOGENOM; CLU_026673_14_1_4; -.
DR OrthoDB; 9770544at2; -.
DR Proteomes; UP000001680; Chromosome 3.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08278; benzyl_alcohol_DH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF12; ALCOHOL DEHYDROGENASE CLASS-3; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5TNX};
KW Metal-binding {ECO:0000256|RuleBase:RU361277, ECO:0007829|PDB:5TNX};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|RuleBase:RU361277, ECO:0007829|PDB:5TNX}.
FT DOMAIN 19..367
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT BINDING 97
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:5TNX"
FT BINDING 100
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:5TNX"
FT BINDING 103
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:5TNX"
FT BINDING 111
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:5TNX"
SQ SEQUENCE 375 AA; 38635 MW; C1C0F1356FAEC413 CRC64;
MYTENDTRAV TAAVARAAGA PFSIEPARIR APRGDEVLVR VVATGLCHTD LIVRDQYYPV
PLPAVLGHEG AGVVEAVGPN VKTLAAGDHV VLTYGACGHC ASCAGGHGAY CRQFFALNFG
GADADGQTAL RDAAGEPLHD HFFAQSSFAS YALARENNAI KVPKEAPLEL LGPLGCGIQT
GAGAVINSLA VRTGSSFASF GAGAVGMSAV MAARIAGATT IIAVDIVPSR LALALELGAT
HAINSKEVDV VDAIREITGG GVDYALESTG LPAVLSQGID ALGSRGTMGV VGAPKLGTKA
EFDVNSLLLG GHTIRGIVEG DSVPQTFIPQ LVQLHLQGRF PFDRLVKFYP LEQINQAAAD
SSSGITLKPI LRLPH
//
