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Database: UniProt
Entry: B1ZTB8_OPITP
LinkDB: B1ZTB8_OPITP
Original site: B1ZTB8_OPITP 
ID   B1ZTB8_OPITP            Unreviewed;       555 AA.
AC   B1ZTB8;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   28-FEB-2018, entry version 68.
DE   SubName: Full=Malate dehydrogenase (Oxaloacetate-decarboxylating) (NADP(+)) {ECO:0000313|EMBL:ACB76572.1};
DE            EC=1.1.1.40 {ECO:0000313|EMBL:ACB76572.1};
GN   OrderedLocusNames=Oter_3293 {ECO:0000313|EMBL:ACB76572.1};
OS   Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1).
OC   Bacteria; Verrucomicrobia; Opitutae; Opitutales; Opitutaceae;
OC   Opitutus.
OX   NCBI_TaxID=452637 {ECO:0000313|EMBL:ACB76572.1, ECO:0000313|Proteomes:UP000007013};
RN   [1] {ECO:0000313|EMBL:ACB76572.1, ECO:0000313|Proteomes:UP000007013}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11246 / JCM 15787 / PB90-1
RC   {ECO:0000313|Proteomes:UP000007013};
RX   PubMed=21398538; DOI=10.1128/JB.00228-11;
RA   van Passel M.W., Kant R., Palva A., Copeland A., Lucas S., Lapidus A.,
RA   Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H.,
RA   Schmutz J., Larimer F.W., Land M.L., Hauser L., Kyrpides N.,
RA   Mikhailova N., Richardson P.P., Janssen P.H., de Vos W.M., Smidt H.;
RT   "Genome sequence of the verrucomicrobium Opitutus terrae PB90-1, an
RT   abundant inhabitant of rice paddy soil ecosystems.";
RL   J. Bacteriol. 193:2367-2368(2011).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003427}.
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DR   EMBL; CP001032; ACB76572.1; -; Genomic_DNA.
DR   RefSeq; WP_012376101.1; NC_010571.1.
DR   ProteinModelPortal; B1ZTB8; -.
DR   STRING; 452637.Oter_3293; -.
DR   EnsemblBacteria; ACB76572; ACB76572; Oter_3293.
DR   KEGG; ote:Oter_3293; -.
DR   eggNOG; ENOG4107R1I; Bacteria.
DR   eggNOG; COG0281; LUCA.
DR   HOGENOM; HOG000042486; -.
DR   KO; K00029; -.
DR   OMA; KVLDYAY; -.
DR   OrthoDB; POG091H06EK; -.
DR   BioCyc; OTER452637:G1GBP-3364-MONOMER; -.
DR   Proteomes; UP000007013; Chromosome.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004473; F:malate dehydrogenase (decarboxylating) (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007013};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003427};
KW   Oxidoreductase {ECO:0000313|EMBL:ACB76572.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007013}.
FT   DOMAIN       83    263       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      273    525       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE    106    106       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    177    177       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       248    248       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       249    249       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       272    272       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   555 AA;  60666 MW;  F92D90012F7707A6 CRC64;
     MASKDTGLQP HGGPSYPRGH ALLLDPLLNK GTAFTEAERD ALGLRGLLPP HVFSMEEQVK
     RVMGNFRRKP DALEKYIFLT SLQNRNETLF YRLVQENLEE MIPIIYTPVV GQACLEFGAI
     FRRPRGLYIS IRDRGRIADI LTHWPVNDVR MIVVTDGERI LGLGDLGALG MGIPIGKLSL
     YTACAGVHPG YTLPIMLDVG TDNTTLHHDP LYIGLNQRRA RGAEYDAFLE EFVTAVAHAF
     PKALLQWEDF GNTNAFRLLH QYRERICSFN DDIQGTAGVA LAGLLGSLRI SGAKLRDQRV
     LFLGAGEAGT GIADLLVAAM REEGLSEAEA RQRCWFVDSQ GLVVQSRLAK LAEHKRPYAH
     DHAFVATLAE AVNALKPTAL IGVSGQAQAF TEPIVRQMAA LNRHPVVFAL SNPTSKAECT
     AEQAYTWTDG RAIFASGSPF PTVKLGEREF VPGQGNNVYI FPGVGLGALV AEASQVTDRM
     FLRGARTLAS LVSAEDIALG RVFPSLTKIR EVSLEIATAV AEEAFKSGLA RRARPADLKA
     DIAARMFVPE YQSYA
//
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