ID B2CYF1_CTEID Unreviewed; 375 AA.
AC B2CYF1;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Growth/differentiation factor 8 {ECO:0000256|ARBA:ARBA00023852, ECO:0000256|RuleBase:RU369049};
DE Short=GDF-8 {ECO:0000256|RuleBase:RU369049};
DE AltName: Full=Myostatin {ECO:0000256|ARBA:ARBA00031866, ECO:0000256|RuleBase:RU369049};
GN Name=gdf-8 {ECO:0000313|EMBL:ACB45875.1};
OS Ctenopharyngodon idella (Grass carp) (Leuciscus idella).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Xenocyprididae; Xenocypridinae; Ctenopharyngodon.
OX NCBI_TaxID=7959 {ECO:0000313|EMBL:ACB45875.1};
RN [1] {ECO:0000313|EMBL:ACB45875.1}
RP NUCLEOTIDE SEQUENCE.
RA Hang L., Ding S.;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACB45875.1}
RP NUCLEOTIDE SEQUENCE.
RA Huang L., Ding S.;
RT "GDF-8 gene cDNA cloning and sequence analysis from grass carp.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AKO90066.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang M., Li J.L., Shen Y.B., Fu J.J., Xu X.Y., Sun J.L.;
RT "Polymorphism of MSTN gene and its association with growth traits and
RT muscle composition in grass carp (Ctenopharyngodon idella).";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts specifically as a negative regulator of skeletal muscle
CC growth. {ECO:0000256|RuleBase:RU369049}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|RuleBase:RU369049}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU369049}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; EU555520; ACB45875.1; -; mRNA.
DR EMBL; KP719016; AKO90066.1; -; Genomic_DNA.
DR AlphaFoldDB; B2CYF1; -.
DR SMR; B2CYF1; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd19388; TGF_beta_GDF8; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF150; GROWTH_DIFFERENTIATION FACTOR 8; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU369049};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU369049};
KW Disulfide bond {ECO:0000256|RuleBase:RU369049};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU369049};
KW Signal {ECO:0000256|RuleBase:RU369049, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..375
FT /note="Growth/differentiation factor 8"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007639511"
FT DOMAIN 263..375
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 375 AA; 42098 MW; B0950648FF1E9811 CRC64;
MHFTQVLISL SVLIACGPVG NGDITAHQQP STATEESEQC STCEFRQHSK LMRLHAIKSQ
ILSKLRLKQA PNISRDVVKQ LLPKAPPLQQ LLDQYDVLGD DSKDGALEED DEHATTETIM
TMATEPDPIV QVDRKPKCCF FSFSPKIQAN RIVRAQLWVH LRPAEEATTV FLQISRLMPV
TDGGRHIRIR SLKIDVSAGV TSWQSIDVKQ VLSVWLRQPE TNWGIEINAY DAKGNDLAIT
SAEAGEDGLL PFMEVKISEG PKRIRRDSGL DCDENSSESR CCRYPLTVDF EDFGWDWIIA
PKRYKANYCS GECDYMHLQK YPHTHLVNKA NPRGTAGPCC TPTKMSPINM LYFNGKEQII
YGKIPSMVVD RCGCS
//
