ID B2G3B0_MACFA Unreviewed; 260 AA.
AC B2G3B0;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=MHC class II DP alpha chain {ECO:0000313|EMBL:CAQ15935.1};
GN Name=mafa-DPA {ECO:0000313|EMBL:CAQ15935.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|EMBL:CAQ15935.1};
RN [1] {ECO:0000313|EMBL:CAQ15935.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Peripheral blood {ECO:0000313|EMBL:CAQ15935.1};
RA Mee E.;
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAQ15935.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Peripheral blood {ECO:0000313|EMBL:CAQ15935.1};
RA Mee E.T., Rose N.J.;
RT "Novel MHC class II sequences obtained from cynomolgus macaques of
RT Indonesian origin.";
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MHC class II family.
CC {ECO:0000256|RuleBase:RU004238}.
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DR EMBL; AM943633; CAQ15935.1; -; mRNA.
DR AlphaFoldDB; B2G3B0; -.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR CDD; cd05767; IgC1_MHC_II_alpha; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF64; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP ALPHA 1 CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..260
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002776558"
FT TRANSMEM 227..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..198
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 260 AA; 29561 MW; 7D491F47D4C79905 CRC64;
MRPEDRMFQT RAVILRTLSL AFLLSLRGAG AIKADHVSTY AMFVQTHRPT GEYMFEFDED
EQFYVDLDKK ETVWHLEEFG RAFSFEAQGG LANIAILNNN LNITIRRSNY TQAANDPPEV
TMFPKEPVEL GQPNTLICHI DKFFPPVLNV TWLCNGQPVT EGVAESLFLP RTDYSFHKFH
YLTFVPSAED YYDCRVEHWG LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG
TVLIIKSLRS GRDPRAQGPL
//
