ID B2GTA5_DANRE Unreviewed; 445 AA.
AC B2GTA5;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=Protein kinase C and casein kinase substrate in neurons protein 1 {ECO:0000256|ARBA:ARBA00013843};
GN Name=pacsin1 {ECO:0000313|EMBL:AAI65817.1};
GN OrderedLocusNames=pacsin1b {ECO:0000313|ZFIN:ZDB-GENE-050913-35};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI65817.1};
RN [1] {ECO:0000313|EMBL:AAI65817.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65817.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection,
CC ruffle membrane {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004284}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
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DR EMBL; BC165817; AAI65817.1; -; mRNA.
DR RefSeq; NP_001028900.1; NM_001033728.1.
DR RefSeq; XP_005166197.1; XM_005166140.2.
DR RefSeq; XP_009301003.1; XM_009302728.2.
DR AlphaFoldDB; B2GTA5; -.
DR SMR; B2GTA5; -.
DR Ensembl; ENSDART00000056830; ENSDARP00000056829; ENSDARG00000042128.
DR Ensembl; ENSDART00000128456; ENSDARP00000107643; ENSDARG00000042128.
DR Ensembl; ENSDART00000162469; ENSDARP00000136926; ENSDARG00000042128.
DR GeneID; 619246; -.
DR KEGG; dre:619246; -.
DR CTD; 619246; -.
DR ZFIN; ZDB-GENE-050913-35; pacsin1b.
DR HOGENOM; CLU_030752_0_0_1; -.
DR OMA; EGGNTYN; -.
DR OrthoDB; 9421at2759; -.
DR PhylomeDB; B2GTA5; -.
DR ExpressionAtlas; B2GTA5; baseline and differential.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:InterPro.
DR GO; GO:0097320; P:plasma membrane tubulation; IEA:InterPro.
DR CDD; cd07680; F-BAR_PACSIN1; 1.
DR CDD; cd11998; SH3_PACSIN1-2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035743; PACSIN1/PACSIN2_SH3.
DR InterPro; IPR037454; PACSIN1_F-BAR.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF16; PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 12..282
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 386..445
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 327..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 187..218
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 327..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 51356 MW; 53552263222290C5 CRC64;
MSGAYDESAM SDETTDSFWE VGNYKRTVKR IEDGHRLCND MMSCIQERAK IEKAYSQQLT
DWSKRWRQLV ERGPQYGTLE RAWLAVMTEA EKVSELHQEV KNNLLNEDLE KVKNWQKDAY
HKQMMGGFKE TKEADEGFRK AQKPWAKKLK ELETAKKTYH MACKEEKIAS AREANSKGEA
SVTTDQQKKL QEKVDKCKND VQKAKEKYEK SLDELNKCTP QYMENMEVVF DQCQQFEEKR
LNFLREVLLD TKRHLNLTES QSYATVYREL ERTIVSASAQ EDLKWFSSVH GPGMHMNWPQ
FEEFNPDLSH AISKKEKVKR NHDGVTLTQV THGAEHGTPQ TGDRGSVSSY EKNQQYSAEW
SDDEQPPTAA QSASETNGGN PFEEDSKGVR VRALYDYEGQ EQDELTFKAG DELTKLEDED
EQGWCKGRLD SGQLGLYPAN YVEPV
//