ID B2HIL9_MYCMM Unreviewed; 916 AA.
AC B2HIL9;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Conserved transmembrane transport protein MmpL7 {ECO:0000313|EMBL:ACC40213.1};
GN Name=mmpL7 {ECO:0000313|EMBL:ACC40213.1};
GN OrderedLocusNames=MMAR_1764 {ECO:0000313|EMBL:ACC40213.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC40213.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC40213.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP000854; ACC40213.1; -; Genomic_DNA.
DR AlphaFoldDB; B2HIL9; -.
DR STRING; 216594.MMAR_1764; -.
DR KEGG; mmi:MMAR_1764; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_327012_0_0_11; -.
DR OrthoDB; 4673837at2; -.
DR PHI-base; PHI:10661; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 797..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..869
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..350
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 587..897
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 916 AA; 93185 MW; 52A7D205B7B28163 CRC64;
MSTDGTHRSS RLVNFLIVAA WIAVAVIANL AVVLAPGKSS DAGSALLSPD STASAASSRI
GQAFPGTGTN AVAYLVVDGP DTLGPADQSY YDAAVNALRA DSRHIGSVLD WWSDPLTVPL
GTGSDGHSAM AMVWLVGQAG STQARESLQA AQSVVHNLPA SAGLRARVVG PTTSSSVPAH
MTVWQGAVIV LATAVIAVLL LLWARRSLVA AAVVLLTAGL SLAVAWPLAA ALRAIPGQNI
SVFTVFSATL AAVLTIGAIA ASTMLVARPG HAPGATAAQP LGRSASRDNL AALAMPAAGV
AILTAPLLLA RTPALHGVGV AALGVVVALA ASLTLLPALI GLTGPSRLSS SRPVGARRTL
PVSIPRTAVV AALVLAVCAV PVIGMQWGIG DGPVNPAAGG TKRALPWQPL PDVVMLEAKH
DLSDPAGLIA IDQVSHRLME IPGVRRVESA AWPAGVPWTD ASLTAAAGKL SDELDRGAGS
FMPQVRAIKT LGSIVDQMSG AVDELDRSVT AGLAGAAQIQ QNVDLLISGT KNIKGVTVEL
SGYLDPVRGW MGDVPNCPGD MLCVAAGKVI DPVDRVVDDV KLLTDGADRI AAVSRKTVGA
FSSAPQVVAQ MRSALAQLQS FVPNLETTIE NTLPQLVQVS AFLKNLRLDF ANTGQGGFYL
SGKALADPSY QQVRQSMFSA DGTATRLLVF SEGNPGLDAS ARAQQLEAAA GKAMKYGSLE
DAEITVNGAA QVATDVRGSL THDAVLLAAM MLAAVVLVSM WRGALTAVVM AVGLLAAYLA
ALGISTALWQ YLAGREIPAA VPLVSFAILA ACGLPYLLDR TATPISTEAP ITSDAQPADT
AALRNAGAPL AALTAVFGLG LVLVSAGSLG ALSQIGTVVL FGVAALTVLA RVCIPAAIQD
RADRTTVATE PVAQPD
//
