ID B2HKL8_MYCMM Unreviewed; 970 AA.
AC B2HKL8;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Conserved transmembrane transport protein, MmpL5_4 {ECO:0000313|EMBL:ACC38723.1};
GN Name=mmpL5_4 {ECO:0000313|EMBL:ACC38723.1};
GN OrderedLocusNames=MMAR_0255 {ECO:0000313|EMBL:ACC38723.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC38723.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC38723.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP000854; ACC38723.1; -; Genomic_DNA.
DR AlphaFoldDB; B2HKL8; -.
DR STRING; 216594.MMAR_0255; -.
DR KEGG; mmi:MMAR_0255; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_3_2_11; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 772..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 826..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 876..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 915..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..389
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 611..943
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 948..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 105223 MW; 3DB78B9F6CC76256 CRC64;
MSTTQSVPGQ TGTTAAERPF VARMIRTLAV PIILFWLAVV VLLSVFVPSL EVVGQERSVS
LSPTDAPSVV ALNRIGHVFN EGETDSVAMI ILEGDKPLGD DAHKFYDGLI RKLRADKKHV
LSIQDFWGDP LTAAGAQSND GMAATVQVSL AGKQGELLAN ESVEAVRKIV DATPAPPGVK
AYVTGGPAMA ADLHKSGDRS MAKITLTTVA VILIMLLFVY RSPVTVFLLL VTVGLELTAA
RGAVALLGHS GLIGLSTFAV SLLTSLAIAA GTDYGIFIVG RYQEARQAGE DRESAFYTMY
RGTAHVILGS GLTISAATFC LSFTRMPYFQ TLGIPCSVGM LVALLVALTL APAVLVVGGR
FGAFDPKRVL QVRGWRRVGT AIVRWPLPIL AVTCAVALVG LITLPGYRPS YNDRAYLPSF
IPANQGLAVA DRHFSQARIN PEILMIESDH DMRNPTDFLV LDKLAKGIFR VPGISRVQAI
TRPSGTTMDH TTIPFRLSMQ NAGQVQSLHY QRARMNDLLT QADEMAKTIA LTRRMYELSS
QLADNTHRMV GDTIEMQQIT NELRDKLADF DDFWRPIRSY LYWEKHCYDI PNCWTFRSLF
DALDGLDQID EKLGVMVGDL ENVDRLMPQM TETFPPMIES MEHIRTMMLT MHSTMSGMVD
QMTELSENAN AMGKAFDTAK NDDSFYLPPE VFENADFKRA MGSFLSPDGH AARFIILHRS
DPASASGIAS IDKIRTAAEE SLKGTPLENA TIYLAGVGAI FKDVSEGAKW DLLIAGIASL
CLIFVIMLIL TRALVAAGVI VGTVAISLGA SFGLSVLLWQ HIIGMPLHWL VIAMSVIVLL
AVGSDYNLLL VSRFKQEIPA GINTGIIRSM GGTGKVVTNA GLVFAFTMAS MVVSDVRMIG
QVGTTIGLGL LFDTLVVRAF MTPAIAALLG RWFWWPLRVR SRPDRRAIQR AAQSDTEPAP
VESAPATAGS
//
