ID B2IXK0_NOSP7 Unreviewed; 4615 AA.
AC B2IXK0;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:ACC81528.1};
DE EC=5.1.1.12 {ECO:0000313|EMBL:ACC81528.1};
DE EC=5.1.1.3 {ECO:0000313|EMBL:ACC81528.1};
GN OrderedLocusNames=Npun_R3026 {ECO:0000313|EMBL:ACC81528.1};
OS Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=63737 {ECO:0000313|EMBL:ACC81528.1, ECO:0000313|Proteomes:UP000001191};
RN [1] {ECO:0000313|Proteomes:UP000001191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACC81528.1, ECO:0000313|Proteomes:UP000001191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191};
RX PubMed=23463784; DOI=10.1104/pp.112.213116;
RA Ekman M., Picossi S., Campbell E.L., Meeks J.C., Flores E.;
RT "A Nostoc punctiforme Sugar Transporter Necessary to Establish a
RT Cyanobacterium-Plant Symbiosis.";
RL Plant Physiol. 161:1984-1992(2013).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP001037; ACC81528.1; -; Genomic_DNA.
DR RefSeq; WP_012409515.1; NC_010628.1.
DR STRING; 63737.Npun_R3026; -.
DR EnsemblBacteria; ACC81528; ACC81528; Npun_R3026.
DR KEGG; npu:Npun_R3026; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_223888_0_0_3; -.
DR OrthoDB; 9757538at2; -.
DR PhylomeDB; B2IXK0; -.
DR Proteomes; UP000001191; Chromosome.
DR GO; GO:0008881; F:glutamate racemase activity; IEA:UniProtKB-EC.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0050157; F:ornithine racemase activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd12115; A_NRPS_Sfm_like; 1.
DR CDD; cd17651; A_NRPS_VisG_like; 1.
DR CDD; cd19543; DCL_NRPS; 3.
DR CDD; cd19534; E_NRPS; 3.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 3.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:ACC81528.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001191}.
FT DOMAIN 996..1070
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2534..2608
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4063..4137
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4615 AA; 518645 MW; D649FB1AB60CF66E CRC64;
MVTVDKKSKG KNIESIYPLS PMQQGMLFHT LYAPETGVYF QQLICTLRGN LNIAAFEQAW
QRVLERHPVL RTAFVWENPK QSFQVVCKLV NIPWFHYDWT SLSPSEQQDA LEAFVQADRD
KGFELKQVPL MRCTLIQIAD DTYTFIWSHH HLLIDGWSLP TIVQEVFAFY DAFNKGDNLY
LKTPRPYEDY ITWLKKQDVS QAELYWREKF QNFTVPTALT VEIPLSKRCL RHTTPTQQSK
YTTQQIKITQ PATTNIQTFA KQHKLTLNNL IQGAWALLLS RYSGQTDIVF GATVSGRPPE
LLGVESMVGL FINTLPVRIT IPEDVEVLPW LKELQAQQVE SEQYSYTPLV EIQGWSEIPG
GMPLFESIVI FENYPVDASV QEKIANLDIS DIRCIEQSNY PLTILAVPGS ELSISISYDT
NRFEAPTIAR MLGHFQTLLE SIAANANQYP SQLSLLTKTE QNQILLEWNN TQTSYFQEQC
IHELFELQVE RSPDAIAIVY ENEQLTYQEL NTKANQLAHH LRSLGVSADI LVGICVERSI
EMLIGILGIL KAGGAYVPLD PNYPQERLSF TLADSQVKVL ITQQQLLPNL PENQAQILCI
DSDWDFIAQS SANNPPRLTT PDNLAYIIYT SGSTGKPKGV LINHANIVRL FTATEEWFHF
NQDDIWTLFH SFAFDFSVWE IWGALIKGGR LVIVPYWISR SPADFYQLLC KQQVTVLNQT
PSAFGQLIQT EELIKTSESL ALRWVIFGGE ALELQSLKPW FERHGDKLPQ LVNMYGITET
TVHVTYRPIT IADLSSNAGS VIGCPIPDLQ VYILDQNRQL LPMGVPGEMY VGGAGLARGY
LNREELTSKV FVAHPFNDDP NARLYKTGDL ARYLGNGDLE YLGRIDNQVK IRGFRIELGE
IEAAISQHPD VQATVVLARV DNPGDKRLVA YLVLNQQLAI SVNELRQFLG SKLPQYMIPA
AFVFLDVLPL TSNGKVDRSG LKAPESGREL ENRFVAPRTP IEQMLSKIWA EVLGVEQIGI
HDNFFELGGD SILSLQIIAR ANLAGVHLSP KQLFEHQTIA LLAAVAGTTR KIQAQQGLVT
GLVPLTPIQH WFFEQNQPEP HHYNQSVLLS VPSDLKPELL KRVLQQLLLH HDALRLRFTP
EKEGWHQVNA DFESTVPLSV VDLSTMSPQE QLAALEDVGG KLQAQLNLCT GPIIRAALFD
LGNQANRLLL TIHHLAVDGV SWRILLDDLQ TGYQQLIRGE AMQLPLKTTS FKHWAQRLSE
YAQSDALAGE LTYWLNPSRQ QVLPIPVDYV QGDNTALYAA TVSVSLNALE TQALLQEVPK
AYNTQINDVL VTALALVLSN WTGSKLLLFN LEGHGREELF EDVDLSRTVG WFTTIFPVLL
ELGTTKDLGN VLKSVKEQLR GIPNKGIGYG LVHYLQKGAE ISSRLQTYST AQISFNYLGQ
FDQVVNTSAG FELDDESVGH SQSLHSRRVH LLDIGGFISE GQLQIDWTYS SNIHQQSTIE
NLANEFIQAL QALIAHCLSP DAGGYTPSDF PLAKLTQTQL DAQLSKIKYQ NLEDIYPLSP
MQQGMLFHSL YASESRAYFE QLNFTVKGNL EILSFEQAWQ QVIAQHSVFR TGFIWDNHHQ
PLQVVYRQVE LALEISDWRE LSAIEQEQQL EIFLESEQRR GFQLSQAPLM RLNLIQLDAD
IYEFIWSHHH LLLDGWSLPL VFKEVFEFYE AICQGKNLDY QPPGDYKNYI AWLQKQNLAK
AKVFWQQKLQ GFSAPTPLVV DKTLKKQQQS SYSKQEIYLP ELATNALQGF ARQHQLTLNN
IVQGAWALLL SRYSGEADVV FGVTVSGRPP ALIGVESMVG LFINTLPLRV EVPESGQLLP
WLKDLQAQQV ESEQYSYTPL VEIQGWSDVP RGMPLFESIV VFENYPIDAS VQQQNAFLEI
SDIHGSEQTN YPLTVSAVPG SQLSVNISYD TSRFEATTIT RMLGHFQTLL EGIVAKPQQH
LSELCLLTAN EQRQLLFEWN NTQKDYPQDR CFHELFEHQV KLTPDAVAVV FENQQFTYQQ
LNSRANQLAH YLQTLGVGAD MLVGICVERS LEMVLGLLGI LKAGGAYVPL DPNYPQERLS
YMLSDSQVSV LLTQQRLFEK LPQHSAQVVC LDTDWNLISQ KSEENSISGV QAGNLAYVIY
TSGSTGQPKG VLVLHKGLLN LVFWHQRTFE VTASDRATQL AGTAFDASVW ELWPYLSAGA
SIYLVKADIL SSLHGLRDWL ICQQITISFV PTPLAEGLLT LEWNDCALRM LLTGGDRLHH
YPSALIPFQL VNNYGPTENT VVTTSGLVVA NEHQDILPSI GRAIANTQVY ILDQYLQPVP
IGVPGELHIG GDSLALGYLN RPELTQEKFI PNPFNNSKFK IPYGNAKGVQ NSKLYKTGDL
ACYLPDGNIE YLGRIDNQVK IRGFRIELGE VETTLSQHPS ISQIAVLVRE DIPGDTCTER
SRSKRLVAYL VLKQDHVLTV SYLRQFLKET LPEYMIPAAF VFLEALPLTS NGKVDQRALP
APDSRQELEV SFVAPRTPIE KMLASIWTDV LRVKQVGIYD NFFELGGDSI LSLQIIARAN
QAGLQLNPKQ LFENPTIVEL MAIAGTTKKI QAEQGLVTGE LPLTPIQHWA FEQNLHEPHH
YNQSVLLSIP FDVKPELLKG VLQQLLLHHD ALRLRFVREG KSWQQFNAAF EKTVPLNIVD
LSTMLSEEQK EALENAGNEF QASLNLVAGP LLQAVLFQFG NGQPSKLLMI IHHLAVDGVS
WRILLEDLLN AYHQLSSGEA IQLPSKTTSF KYWAQKLSEY AQSDALKDEL TYWLNPSRKQ
VLPIPVDYEQ GTNIVADATT VTVSLTTEET QALLQEVPKA YNTQINDVLL TALVQVLGKW
TGSNLLLDLE GHGREDIFTD VDLSRTVGWF TTIFPVLLEL SVNEDLGNIL KSIKEQLRQI
PDKGIGYGIL RYLQQDAEIS SCLQTYPPAQ ISFNYLGQFD QALSKSADFQ LTTESLGAVQ
SLNNLRSHLL DINGIIVQGQ LQIDWTYSKN SHQYATIKNL AQEFIEVLRS LIAHCLSPEV
GGYTPSDFPL ARLTQAQLDT QLSKTTARNL EDIYPLSPMQ QGMLFHSVYE PESGVYFQQL
SCILKGNLEI PAFEQAWQQV INRHSIFRTG FIWENHHQPL QLVYRQVKLP LEIDDWRALS
SSEQQEKLDI FLKSEQQHSF KLSLAPLMCL NLIQLDAAAY QFIWSYHHLL LDGWSLPLVL
KEVFDYYEAI CQGKNLRHEP SSPYRNYIAW LQKQDLGQAE IYWQQKLQGF TAPTSLMVDK
SLIGQEQHSS YSEQEIYLPQ TVTNALESFA RRHQLTLNNL VQGAWAVLLS RYSGEADVVF
GATVSGRPPT LVGVESMVGL FINTLPVRVI ISENEELLPW LKDLQAQQVE CEQYSYTPLV
EIQNWSEIPR GMSLFESLVV FENYPVDASV QEQNGSLEVS GVRGMEQTNY PLTVLAIPGQ
ELTVKMSYDT SRFEAATISR MLGHFQTLLE GFVTNQNQQL RELSLLTPDE QQQLLIEWNT
TQTDYPQNLC IHELFAVQVK RTPDAVAIVF ENQQLTYTEL NHRANQLAHY LQSLGVKPDV
LVGICVKRSL EMVVGLLGIL KAGGAYVALD PDYPQERLGY TLRDSQLSVL LTQEQLVDKL
PEHQAQVVCL DENWQELAKF PTTNLQSFVQ PTNLAYVLYT SGSTGRPKGV AIEHKSPVAL
ISWAKEVFTP QQLAGVLAST SICFDLSVFE LFVPLSWGGK VILAENALHL PTLPAAEQVT
LINTVPSAIS ELIRVNGIPA GVSTVNLAGE PLQNQLVQQI YQQETVKYVF NLYGPSEDTT
YSTFALIPQG ATVAPSIGRP ISNTQAYILD QNLQPVPIGV PGELHLGGAG LAQGYLNRPD
LTQERFINSK FKIPYGNAKV VQNSKLESER LYKTGDLARY LPDGNIEYLG RIDNQVKIRG
FRIELGEIET VLNENPAVFQ AVVIAREDDP GVKRLVAYLV LKQEQTPTVT ELRQFLTSKL
PDYMIPAAFV FLAALPMTPN GKIDRRALPI PESRSELEVS FVAATTSIEQ KLALIWAEVL
RSQQVGIHDN FFELGGDSIL SLQIIARANQ AGLQLSPKQL FEHQTIAQLA KVVGTTKKIQ
AQQDLVTGIV PLTPIQHWFF AQNQPQPHHY NQSVLLSVPS DLDVELLRRV LQQLLLHHDA
LRLRFVLDAV IWKQFNAAFE ETVALSVVDL STLSPQEQPA ALENAGSEFQ ASLSLSTGPL
MRAVLFTLGD NQPSRLLLVI HHLAVDGVSW RILLDDLQTG YQQLIRAEVI QLPPKTTSFQ
YWSLQLTKYA QSAALSSEIN YWLAESATNI TPLPVDYPPT KETNTIASSA YVSLSLSSEE
TDTLLQEVPA VYNTQINDVL LTALMQSFTQ WTGSDSLLVD LEGHGREELF EDVDLSRTVG
WFTTLFPVHL KLGDETNPGE ALKLVKEQLR RLPMRGIGYG VLRYLSQDAE QLEHLPKAEV
SFNYLGQFNR ESSAIATWEF AQESGGTEHS LQEYRNYLLQ VSGLVMNGEL QINWEYSEKV
HQRSTVERLA RQFMEALRTL IQHCQLPNVG GFTPSDFPKA GLSQEDIDDI LADIN
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