ID B2J4D4_NOSP7 Unreviewed; 585 AA.
AC B2J4D4;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Thiamine pyrophosphate enzyme domain protein TPP-binding {ECO:0000313|EMBL:ACC83624.1};
DE EC=2.2.1.6 {ECO:0000313|EMBL:ACC83624.1};
GN OrderedLocusNames=Npun_R5303 {ECO:0000313|EMBL:ACC83624.1};
OS Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=63737 {ECO:0000313|EMBL:ACC83624.1, ECO:0000313|Proteomes:UP000001191};
RN [1] {ECO:0000313|Proteomes:UP000001191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACC83624.1, ECO:0000313|Proteomes:UP000001191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191};
RX PubMed=23463784; DOI=10.1104/pp.112.213116;
RA Ekman M., Picossi S., Campbell E.L., Meeks J.C., Flores E.;
RT "A Nostoc punctiforme Sugar Transporter Necessary to Establish a
RT Cyanobacterium-Plant Symbiosis.";
RL Plant Physiol. 161:1984-1992(2013).
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; CP001037; ACC83624.1; -; Genomic_DNA.
DR RefSeq; WP_012411575.1; NC_010628.1.
DR AlphaFoldDB; B2J4D4; -.
DR STRING; 63737.Npun_R5303; -.
DR EnsemblBacteria; ACC83624; ACC83624; Npun_R5303.
DR KEGG; npu:Npun_R5303; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_1_3; -.
DR OrthoDB; 9785953at2; -.
DR PhylomeDB; B2J4D4; -.
DR Proteomes; UP000001191; Chromosome.
DR GO; GO:0003984; F:acetolactate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd00568; TPP_enzymes; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; NF035927; TPP_ScyA_rel; 1.
DR PANTHER; PTHR18968:SF13; ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001191};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132};
KW Transferase {ECO:0000313|EMBL:ACC83624.1}.
FT DOMAIN 32..142
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 237..359
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 418..560
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 585 AA; 62750 MW; A7DD8DD6BEA16488 CRC64;
MHVKYQDTQA NTTEQLNSTG QQSHSKLSRP SSVAETVVKM LGDMGVEYAF GVSGGAIAPV
WAALHQSSIQ VLHFRHEAGA AFAAIEAYFA SDRPVVVFTT TGPGITNALT GLLAARWEGA
KVIFVSASTS SPQRGRWACQ ETSTYTMPSA GLFTSGTIFH YATTLESSDE LSEVARRIAL
GLGQPGGFVA HISIPANIQT TSVNTSLPRV TLSQSMGTAS EETIAKCVRL LSEGPFAIWV
GFGARGAAKE IRQLAERTGA AVMCSPRAKG IFPEDHPQFV GVTGFGGHDS VFRYMREQVP
RHILVLGTRL GEFTSFWNPE MIPKQSFLHV DIDPKVPGSA YPSVETLAIH SDVRLFVKAV
LKYFPESLSL STALSLPRPI HNVVHPCTSN LVLPNILMNG IQQVIVEGSD ALVLAEGGNS
FAWAINFLQF AKPGRFRAST GFSAMGHTCT GIVGAALARR GKAVAIVGDG AMLMNNEVNT
AVAYQIPAVW IVLNDGRYNM CEQGMTYVGF KDVDATIPQV DFVKIAQGMG ADGIRVETEY
EIQTALEKAI AATDPFVVDV IIDPTQIAPT HNRNQSLISQ GATNY
//
