ID B2J8J6_NOSP7 Unreviewed; 928 AA.
AC B2J8J6;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Npun_R2408 {ECO:0000313|EMBL:ACC80973.1};
OS Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=63737 {ECO:0000313|EMBL:ACC80973.1, ECO:0000313|Proteomes:UP000001191};
RN [1] {ECO:0000313|Proteomes:UP000001191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACC80973.1, ECO:0000313|Proteomes:UP000001191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191};
RX PubMed=23463784; DOI=10.1104/pp.112.213116;
RA Ekman M., Picossi S., Campbell E.L., Meeks J.C., Flores E.;
RT "A Nostoc punctiforme Sugar Transporter Necessary to Establish a
RT Cyanobacterium-Plant Symbiosis.";
RL Plant Physiol. 161:1984-1992(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001037; ACC80973.1; -; Genomic_DNA.
DR RefSeq; WP_012408967.1; NC_010628.1.
DR AlphaFoldDB; B2J8J6; -.
DR STRING; 63737.Npun_R2408; -.
DR EnsemblBacteria; ACC80973; ACC80973; Npun_R2408.
DR KEGG; npu:Npun_R2408; -.
DR eggNOG; COG4191; Bacteria.
DR eggNOG; COG4585; Bacteria.
DR eggNOG; COG5000; Bacteria.
DR HOGENOM; CLU_000445_114_10_3; -.
DR OrthoDB; 447151at2; -.
DR PhylomeDB; B2J8J6; -.
DR Proteomes; UP000001191; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF10; SENSORY TRANSDUCTION HISTIDINE KINASE; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR Pfam; PF13426; PAS_9; 2.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACC80973.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001191};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 382..434
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 523..577
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 610..673
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 840..928
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 928 AA; 104864 MW; 22E543D60BA17051 CRC64;
MFNKISYLQY FLSLPVKPSL RTVLIIPFIL QILAVASLTG YLSFKNGQKA VNNIATRLLS
EISQRVQQNL HTFLETPQQI NQNNANAIKL GQLDVQDLTV LEHYFFDQLE VFNQVSLIGF
ANTNKEFISA EIFPDGSLTI RASGKSTKYN LRTYTTNKQS TRTGIKDFGK PYDTQRRNWY
NKAIAKQRPV WSEIYPHNSG IALYIAASQP AYDKQGNLQG VLLSNLNLSK IGTFLQNLKI
GKTGISFIVE RHSGRLVATS TNEKPFHSNN FKTQLAENRI KPFLAIDSKD KKTQCTSKYL
KSKFNEFKSI NSSQQLYFSI DGKRQFIRVL PFQDNRGLDW LIVVVVPEND FMEEINANTR
TTIVLCIVAL IVAVAVGVLI LRWIAEPVLA LKKSALALAQ GEWEKRIKIE RSDELGELAR
SFNNMADQLQ AKFSEMQDLN KALLQSETRL KQFLDAVPVA ISINDPYGEI YYNNRAVQKL
ISVDLLPSIK PEKIAEYYQI YLAETDYLYP TDELPIMYSL VGKTVHIDNM EFRHPNKTIP
IEVLSTPIFD ESGKVIYALT VCIDITERKK AEKILADYNS VLEQQVTQRT LELQREIAER
KQAEVALLES ETRFRLLAEA TFEAIAITEQ GILLDTNQTC AEMFGYELSE LLGMRVMDFT
APEYREQVMQ KIRSGDEGIY ETVCLRKDGS TFPAEIRARV MSYRGRTIRM AAIQDITSRK
QAEEATVLAE RNRLAQEIHD TLAQAFTVVI VHLDTASRKL TTDIEVAQKL IKAGRDLAHS
GLTEARRSIK ALRSQLLEDG NIFNALNRFA TQMFSPSNTH IVCQLIGEIY PLSPDVENNL
LRIGQEALTN AFKYAQAGEI QIELAYQESQ CSLRIKDDGQ GFDIASVSVI NSFGLLVMSE
RAECIGAKLT IQSSPGQGTE VSVLVYRE
//
