ID B2KBB2_ELUMP Unreviewed; 671 AA.
AC B2KBB2;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Alkaline phosphatase superfamily {ECO:0000313|EMBL:ACC97934.1};
GN OrderedLocusNames=Emin_0377 {ECO:0000313|EMBL:ACC97934.1};
OS Elusimicrobium minutum (strain Pei191).
OC Bacteria; Elusimicrobiota; Elusimicrobia; Elusimicrobiales;
OC Elusimicrobiaceae; Elusimicrobium.
OX NCBI_TaxID=445932 {ECO:0000313|EMBL:ACC97934.1, ECO:0000313|Proteomes:UP000001029};
RN [1] {ECO:0000313|EMBL:ACC97934.1, ECO:0000313|Proteomes:UP000001029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pei191 {ECO:0000313|EMBL:ACC97934.1,
RC ECO:0000313|Proteomes:UP000001029};
RX PubMed=19270133; DOI=10.1128/AEM.02698-08;
RA Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H.,
RA Lapidus A., Hugenholtz P., Brune A.;
RT "Genomic analysis of 'Elusimicrobium minutum,' the first cultivated
RT representative of the phylum 'Elusimicrobia' (formerly termite group 1).";
RL Appl. Environ. Microbiol. 75:2841-2849(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001055; ACC97934.1; -; Genomic_DNA.
DR RefSeq; WP_012414549.1; NC_010644.1.
DR AlphaFoldDB; B2KBB2; -.
DR STRING; 445932.Emin_0377; -.
DR KEGG; emi:Emin_0377; -.
DR HOGENOM; CLU_014653_2_0_0; -.
DR OrthoDB; 9760224at2; -.
DR Proteomes; UP000001029; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16015; LTA_synthase; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012160; LtaS-like.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001029};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 285..571
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT ACT_SITE 333
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT BINDING 292
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 333
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 446
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT BINDING 513
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 514
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ SEQUENCE 671 AA; 76752 MW; A2708D142AE8C2EA CRC64;
MSFSQKLSRV PNWVKGYTGF FAATWLAFFL MRFVFLFVYR AAITAEVKTY LLQSFYIGAK
FDARLAAFLA LPLGLYLFIK SIFPKIPAVF NKIMASLYTV ILTGAGLVYA GDFGHYSYLG
LRVNASLFKY LENAFISFEM VWQTYPVVWA SLGFILLMFL AYKYAMFFIK LGQPASNDGW
KKKTSWFLIL FVLTFGVCYG QINQYPLRWS NAYFSSNNFI SNLTLNPVLN IYDTYRFAKE
DSYNIEAVKK YYPIMAEYLG VDNPDINTLN FKREVKGKDL GRQFNIVVIF MESFAWNKSS
FSNTGKFDTT PNAKALAEQS ILFTQFYTPT SATARAVFAA LSSIPDVSSF KTSSRNPLIV
NQNLIANELE GYDKFFFIGG SASWGNIRGI LSHNLDGLQL YEEEDYESKR VDVWGISDWD
LFIEADKVLA KQERPFFAVI QTAGYHRPYT IPPHDEGFKL EKDISYEDLV NHSFGSIEEF
NSLRFSDYAL GEFFRRARKS PYYKDTVFVI FGDHGLDAPK SENMPRGYVE YNLINHHVPL
IIHAPALSKG RVVNKTASQV DIMPTVAGLI GAPYETVALG RDVLDPKYKE KEGALVFGWS
KYPPTISFVS GEYLYHDQTT QKGLYKFGAK DYNKDLAEEN PELYKKMEDL SAGIYETSRY
MLYNNPKKEK K
//
