ID B2KJ26_DANRE Unreviewed; 704 AA.
AC B2KJ26;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|RuleBase:RU367105};
DE EC=2.3.2.27 {ECO:0000256|RuleBase:RU367105};
GN Name=dtx1 {ECO:0000313|EMBL:ABF61770.1,
GN ECO:0000313|RefSeq:NP_001120780.1};
GN Synonyms=si:ch211-119e14.2 {ECO:0000313|RefSeq:NP_001120780.1};
GN OrderedLocusNames=dtx4a {ECO:0000313|RefSeq:NP_001120780.1,
GN ECO:0000313|ZFIN:ZDB-GENE-160728-59};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ABF61770.1};
RN [1] {ECO:0000313|EMBL:ABF61770.1}
RP NUCLEOTIDE SEQUENCE.
RA Wee I.X., Tan S.C.C., Xu H., Jiang Y.-J.;
RT "Cloning and expression pattern of three zebrafish deltex genes.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001120780.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22538478;
RA Blackburn J.S., Liu S., Raiser D.M., Martinez S.A., Feng H., Meeker N.D.,
RA Gentry J., Neuberg D., Look A.T., Ramaswamy S., Bernards A., Trede N.S.,
RA Langenau D.M.;
RT "Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic
RT leukemia clones without affecting leukemia-propagating cell frequency.";
RL Leukemia 26:2069-2078(2012).
RN [3] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_001120780.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26714454; DOI=10.1186/s13064-015-0055-5;
RA Cheng Y.C., Huang Y.C., Yeh T.H., Shih H.Y., Lin C.Y., Lin S.J., Chiu C.C.,
RA Huang C.W., Jiang Y.J.;
RT "Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and
RT induces neuronal and glial differentiation.";
RL Neural Dev. 10:28-28(2015).
RN [5] {ECO:0000313|RefSeq:NP_001120780.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [6] {ECO:0000313|RefSeq:NP_001120780.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28631837;
RA Shi W.J., Zhao J.L., Jiang Y.X., Huang G.Y., Liu Y.S., Zhang J.N.,
RA Ying G.G.;
RT "Transcriptional and histological alterations in gonad of adult zebrafish
RT after exposure to the synthetic progestin norgestrel.";
RL Environ. Toxicol. Chem. 36:3267-3276(2017).
RN [7] {ECO:0000313|RefSeq:NP_001120780.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [8] {ECO:0000313|RefSeq:NP_001120780.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900,
CC ECO:0000256|RuleBase:RU367105};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906, ECO:0000256|RuleBase:RU367105}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367105}.
CC -!- SIMILARITY: Belongs to the Deltex family.
CC {ECO:0000256|ARBA:ARBA00009413, ECO:0000256|RuleBase:RU367105}.
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DR EMBL; DQ497599; ABF61770.1; -; mRNA.
DR RefSeq; NP_001120780.1; NM_001127308.1.
DR GeneID; 570481; -.
DR KEGG; dre:570481; -.
DR CTD; 570481; -.
DR ZFIN; ZDB-GENE-160728-59; dtx4a.
DR OrthoDB; 5487971at2759; -.
DR PhylomeDB; B2KJ26; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000437; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR CDD; cd09633; Deltex_C; 1.
DR CDD; cd16671; RING-H2_DTX1_4; 1.
DR Gene3D; 3.30.390.130; -; 1.
DR Gene3D; 3.30.720.50; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039396; Deltex_C.
DR InterPro; IPR039399; Deltex_C_sf.
DR InterPro; IPR039398; Deltex_fam.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR018123; WWE-dom_subgr.
DR InterPro; IPR037197; WWE_dom_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12622; DELTEX-RELATED; 1.
DR PANTHER; PTHR12622:SF5; E3 UBIQUITIN-PROTEIN LIGASE DTX4; 1.
DR Pfam; PF18102; DTC; 1.
DR Pfam; PF02825; WWE; 2.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00678; WWE; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF117839; WWE domain; 2.
DR PROSITE; PS50918; WWE; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|RuleBase:RU367105};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367105};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367105};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367105};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1..78
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 79..155
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 494..555
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 232..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..250
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..322
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 75113 MW; 6D898AFF542ABB69 CRC64;
MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVIRSDPRG AGSVVLGQVD SRLSPYIIDL
QSMHQFRQDT GTLRPVRRSF YDPRSAPGQG WVWEWENDSG SWTPYDTEVS IAIQAARDRQ
QPWLDLTPLG FCYLIDLQSM TQINGQTQRR RRIQRRSDLA YPLVSGPLPK PHAWSSAGSG
GLLGVGVSGV SGGNGSAYPS GALPASAITS LGQPCSCQQC MLVLGVKTPS MAQTLGRKPP
PIPKPPSPKA PSRGHSYSLT LPHPPSLSRV LSPHRNSTSG ASGGFGHSLS LLGSATAALS
ISSNRPPPPT VPPPPPPSTT PHTTSMANPT APTPSSTLIS TATTCAPTPS ARVLGPVSTA
SAACAAPVPP CSSLAGLSRP ALQRIAMAQS RALIASGVPT VPVKNLNGSS PVHPALAGIT
GILMSAAGLP VCLTRPPKLV LHPPPVSKSD IKPVPGLGHC CRKTTKKQAR KGRTSEEVVR
RYLQKVRNPP EEDCTICMES LCGPSGYKGP GVGGISRAES VGRLSQCGHQ YHLQCLVAMY
NNGNKDGSLQ CPTCKTIYGV KTGNQPPGKM EYHVIPHSLP GHPDCKTIRI IYNIPPGIQG
PEHPNPGKPF TARGFPRHCY LPDSEKGRLV LKLLLVAWDR RLIFSVGTSS TTGETDTVIW
NEVHHKTEFG SNLTGHGYPD SGHLDNVLKE LRAQGITEEE CLRD
//