ID B2KKY9_DANRE Unreviewed; 176 AA.
AC B2KKY9;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Bcl-2 interacting mediator of cell death {ECO:0000313|EMBL:ABS45110.1};
DE SubName: Full=Bcl-2-like protein 11 {ECO:0000313|RefSeq:NP_001129263.1};
GN Name=bim {ECO:0000313|EMBL:ABS45110.1,
GN ECO:0000313|RefSeq:NP_001129263.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ABS45110.1};
RN [1] {ECO:0000313|EMBL:ABS45110.1, ECO:0000313|RefSeq:NP_001129263.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18404156; DOI=10.1038/cdd.2008.42;
RA Jette C.A., Flanagan A.M., Ryan J., Pyati U.J., Carbonneau S.,
RA Stewart R.A., Langenau D.M., Look A.T., Letai A.;
RT "BIM and other BCL-2 family proteins exhibit cross-species conservation of
RT function between zebrafish and mammals.";
RL Cell Death Differ. 15:1063-1072(2008).
RN [2] {ECO:0000313|RefSeq:NP_001129263.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20674670;
RA Peng K., Li Y., Long L., Li D., Jia Q., Wang Y., Shen Q., Tang Y., Wen L.,
RA Kung H.F., Peng Y.;
RT "Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic
RT development in zebrafish.";
RL Neurosci. Lett. 484:98-103(2010).
RN [3] {ECO:0000313|RefSeq:NP_001129263.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24378359; DOI=10.3791/51060;
RA Sorrells S., Toruno C., Stewart R.A., Jette C.;
RT "Analysis of apoptosis in zebrafish embryos by whole-mount
RT immunofluorescence to detect activated Caspase 3.";
RL J. Vis. Exp. 0:e51060-e51060(2013).
RN [4] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001129263.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26598622;
RA Ittig S.J., Schmutz C., Kasper C.A., Amstutz M., Schmidt A., Sauteur L.,
RA Vigano M.A., Low S.H., Affolter M., Cornelis G.R., Nigg E.A.,
RA Arrieumerlou C.;
RT "A bacterial type III secretion-based protein delivery tool for broad
RT applications in cell biology.";
RL J. Cell Biol. 211:913-931(2015).
RN [6] {ECO:0000313|RefSeq:NP_001129263.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [7] {ECO:0000313|RefSeq:NP_001129263.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30237469; DOI=10.1038/s41419-018-0992-0;
RA Suraweera C.D., Caria S., Jarva M., Hinds M.G., Kvansakul M.;
RT "A structural investigation of NRZ mediated apoptosis regulation in
RT zebrafish.";
RL Cell Death Dis. 9:967-967(2018).
RN [8] {ECO:0000313|RefSeq:NP_001129263.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29874755;
RA Liu J., Sun L., Zhang H., Shi M., Dahlgren R.A., Wang X., Wang H.;
RT "Response mechanisms to joint exposure of triclosan and its chlorinated
RT derivatives on zebrafish (Danio rerio) behavior.";
RL Chemosphere 193:820-832(2018).
RN [9] {ECO:0000313|RefSeq:NP_001129263.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30840854;
RA Weiner A.M.J., Scampoli N.L., Steeman T.J., Dooley C.M.,
RA Busch-Nentwich E.M., Kelsh R.N., Calcaterra N.B.;
RT "Dicer1 is required for pigment cell and craniofacial development in
RT zebrafish.";
RL Biochim Biophys Acta Gene Regul Mech 1862:472-485(2019).
RN [10] {ECO:0000313|RefSeq:NP_001129263.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31064769; DOI=10.1242/dmm.035790;
RA Gjini E., Jing C.B., Nguyen A.T., Reyon D., Gans E., Kesarsing M.,
RA Peterson J., Pozdnyakova O., Rodig S.J., Mansour M.R., Joung K., Look A.T.;
RT "Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish.
RT .";
RL Dis. Model. Mech. 12:dmm035790-dmm035790(2019).
RN [11] {ECO:0000313|RefSeq:NP_001129263.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30718751;
RA Park K.H., Ye Z.W., Zhang J., Hammad S.M., Townsend D.M., Rockey D.C.,
RA Kim S.H.;
RT "3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic
RT injury in zebrafish.";
RL Sci. Rep. 9:1138-1138(2019).
RN [12] {ECO:0000313|RefSeq:NP_001129263.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EF539840; ABS45110.1; -; mRNA.
DR RefSeq; NP_001129263.1; NM_001135791.1.
DR TCDB; 8.A.69.1.2; the pro-apoptotic bcl-2-family protein bim (bim) family.
DR GeneID; 100190951; -.
DR KEGG; dre:100190951; -.
DR AGR; ZFIN:ZDB-GENE-081008-1; -.
DR CTD; 10018; -.
DR ZFIN; ZDB-GENE-081008-1; bcl2l11.
DR OrthoDB; 4327858at2759; -.
DR Proteomes; UP000000437; Chromosome 13.
DR InterPro; IPR015040; Bcl-x_interacting_BH3_dom.
DR Pfam; PF08945; Bclx_interact; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 118..140
FT /note="Bcl-x interacting BH3"
FT /evidence="ECO:0000259|Pfam:PF08945"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 176 AA; 19112 MW; A97660F121682380 CRC64;
MSDTSREQTL ANGPASQGSG ESTGGGVVLP AGHFDFPQPG EGDPLRGGIS MSNNQSRSPM
NRTFSRSSSG YFSVDSDSVP GSPLMPNISE AQDGQNDEVW LSEHSHQHLQ MAAPVAALPP
EMVVARELRR IGDEFNRLYC EAGAGVNQLR APNEHAIVLW MNVIIGRLVH FFLRRR
//
