ID S2538_SHEEP Reviewed; 306 AA.
AC B2MVX9;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 08-NOV-2023, entry version 53.
DE RecName: Full=Mitochondrial glycine transporter {ECO:0000255|HAMAP-Rule:MF_03064};
DE AltName: Full=Solute carrier family 25 member 38 {ECO:0000255|HAMAP-Rule:MF_03064};
GN Name=SLC25A38 {ECO:0000255|HAMAP-Rule:MF_03064};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Deng W.;
RT "Molecular clone and sequence analysis of SLC25A38 from black-boned sheep
RT (Ovis aries).";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial glycine transporter that imports glycine into
CC the mitochondrial matrix. Plays an important role in providing glycine
CC for the first enzymatic step in heme biosynthesis, the condensation of
CC glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the
CC mitochondrial matrix. Required during erythropoiesis.
CC {ECO:0000255|HAMAP-Rule:MF_03064}.
CC -!- FUNCTION: Plays a role as pro-apoptotic protein that induces caspase-
CC dependent apoptosis. {ECO:0000250|UniProtKB:Q91XD8}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715,
CC ChEBI:CHEBI:57305; Evidence={ECO:0000250|UniProtKB:Q96DW6};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_03064}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03064}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC SLC25A38 subfamily. {ECO:0000255|HAMAP-Rule:MF_03064}.
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DR EMBL; EU626218; ACC93613.1; -; mRNA.
DR RefSeq; NP_001120747.1; NM_001127275.1.
DR AlphaFoldDB; B2MVX9; -.
DR SMR; B2MVX9; -.
DR STRING; 9940.ENSOARP00000002484; -.
DR PaxDb; 9940-ENSOARP00000002484; -.
DR Ensembl; ENSOART00020027739; ENSOARP00020023006; ENSOARG00020017915.
DR GeneID; 100147784; -.
DR KEGG; oas:100147784; -.
DR CTD; 54977; -.
DR eggNOG; KOG0766; Eukaryota.
DR OrthoDB; 5174168at2759; -.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0015187; F:glycine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR GO; GO:1904983; P:glycine import into mitochondrion; IEA:UniProtKB-UniRule.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR HAMAP; MF_03064; SLC25A38; 1.
DR InterPro; IPR030847; Hem25/SLC25A38.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR46181; MITOCHONDRIAL GLYCINE TRANSPORTER; 1.
DR PANTHER; PTHR46181:SF3; MITOCHONDRIAL GLYCINE TRANSPORTER; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..306
FT /note="Mitochondrial glycine transporter"
FT /id="PRO_0000378920"
FT TRANSMEM 31..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 89..115
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 127..152
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 180..203
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 221..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 276..294
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 25..114
FT /note="Solcar 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 121..205
FT /note="Solcar 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 217..301
FT /note="Solcar 3"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
SQ SEQUENCE 306 AA; 33593 MW; 6B5405C8FD54114C CRC64;
MIQKSRPALL QHQDVGDRVE TLMLQPVIKA FLCGSISGTC STVLFQPLDL LKTRLQTLQP
SAHGSRRVGM LALLLTVVRT ESLLGLWKGM SPSIVRCVPG VGIYFGTLYS LKQYFLRGHP
PTALESVILG AGSRSVAGVC MSPITVIKTR YESGRYGYQS IYAALRSICH SEGFRGLFSG
LTATLLRDAP FSGIYLMFYS QTKNVVLHST DQLDAVLVPV VNFSCGIFAG ILASLVTQPA
DVIKTHMQLS PVKFRWIGQS VTLIFKDYGL RGFFQGSVPR ALRRTLVAAM AWTVYEEMMA
KMGLKS
//
