ID B2RQP1_MOUSE Unreviewed; 735 AA.
AC B2RQP1;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 01-MAY-2013, entry version 45.
DE SubName: Full=Ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent);
GN Name=Rnasel; ORFNames=mCG_20127;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mixed;
RX PubMed=12040188; DOI=10.1126/science.1069193;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and
RT the human genome.";
RL Science 296:1661-1671(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mixed;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; BC138013; AAI38014.1; -; mRNA.
DR EMBL; CH466520; EDL39426.1; -; Genomic_DNA.
DR IPI; IPI00114711; -.
DR RefSeq; NP_036012.1; NM_011882.2.
DR UniGene; Mm.259254; -.
DR SMR; B2RQP1; 23-354, 356-708.
DR GeneID; 24014; -.
DR KEGG; mmu:24014; -.
DR UCSC; uc007daf.1; mouse.
DR CTD; 6041; -.
DR MGI; MGI:1098272; Rnasel.
DR HOVERGEN; HBG012673; -.
DR InParanoid; B2RQP1; -.
DR KO; K01165; -.
DR OMA; NMGRNAL; -.
DR NextBio; 303947; -.
DR Genevestigator; B2RQP1; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:Compara.
DR GO; GO:0051607; P:defense response to virus; IEA:Compara.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Compara.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
DR Gene3D; 1.25.40.20; -; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR000719; Prot_kinase_cat_dom.
DR InterPro; IPR006567; PUG-dom.
DR Pfam; PF00023; Ank; 6.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SMART; SM00580; PUG; 1.
DR SUPFAM; SSF48403; ANK; 1.
DR SUPFAM; SSF56112; Kinase_like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Repeat.
SQ SEQUENCE 735 AA; 83275 MW; B6632F4A5B50F711 CRC64;
METPDYNTPQ GGTPSAGSQR TVVEDDSSLI KAVQKGDVVR VQQLLEKGAD ANACEDTWGW
TPLHNAVQAG RVDIVNLLLS HGADPHRRKK NGATPFIIAG IQGDVKLLEI LLSCGADVNE
CDENGFTAFM EAAERGNAEA LRFLFAKGAN VNLRRQTTKD KRRLKQGGAT ALMSAAEKGH
LEVLRILLND MKAEVDARDN MGRNALIRTL LNWDCENVEE ITSILIQHGA DVNVRGERGK
TPLIAAVERK HTGLVQMLLS REGINIDARD NEGKTALLIA VDKQLKEIVQ LLLEKGADKC
DDLVWIARRN HDYHLVKLLL PYVANPDTDP PAGDWSPHSS RWGTALKSLH SMTRPMIGKL
KIFIHDDYKI AGTSEGAVYL GIYDNREVAV KVFRENSPRG CKEVSCLRDC GDHSNLVAFY
GREDDKGCLY VCVSLCEWTL EEFLRLPREE PVENGEDKFA HSILLSIFEG VQKLHLHGYS
HQDLQPQNIL IDSKKAVRLA DFDQSIRWMG ESQMVRRDLE DLGRLVLYVV MKGEIPFETL
KTQNDEVLLT MSPDEETKDL IHCLFSPGEN VKNCLVDLLG HPFFWTWENR YRTLRNVGNE
SDIKVRKCKS DLLRLLQHQT LEPPRSFDQW TSKIDKNVMD EMNHFYEKRK KNPYQDTVGD
LLKFIRNIGE HINEEKKRGM KEILGDPSRY FQETFPDLVI YIYKKLKETE YRKHFPQPPP
RLSVPEAVGP GGIQS
//
