ID B2RUK0_MOUSE Unreviewed; 1520 AA.
AC B2RUK0;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Rusc2 protein {ECO:0000313|EMBL:AAI41187.1};
GN Name=Rusc2 {ECO:0000313|EMBL:AAI41187.1, ECO:0000313|MGI:MGI:2140371};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI41187.1};
RN [1] {ECO:0000313|EMBL:AAI41187.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI41187.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; BC141186; AAI41187.1; -; mRNA.
DR PeptideAtlas; B2RUK0; -.
DR AGR; MGI:2140371; -.
DR MGI; MGI:2140371; Rusc2.
DR ChiTaRS; Rusc2; mouse.
DR CDD; cd17702; RUN_RUSC2; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047342; RUN_RUSC2.
DR InterPro; IPR047343; RUSC1_2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15591:SF14; AP-4 COMPLEX ACCESSORY SUBUNIT RUSC2; 1.
DR PANTHER; PTHR15591; RUN AND SH3 DOMAIN CONTAINING; 1.
DR Pfam; PF02759; RUN; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1034..1178
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 1451..1510
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 75..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1287..1304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1520 AA; 161791 MW; 7FCB4B9255EA9D7D CRC64;
MPLLELSRMD SPPKLTGETL IVHHIPLVHC QVPDRQCCGG AGGGGGGTRA NPFCPPELGL
TQPDHDLGQA DSLLYPSLHS APGAPTGSSD SVKSRSRDGR GPGAPKRHNP FLVQEGVGET
GLGDLHDSST GDSVTQQSFH LHSASQPFHL SSFQLPPSGP GQGRPWGATR SRPGVVEGQE
QDPATALGTQ CSTSHYCRPE LEAERMELDE CGGHGGSGSG GGASDISGFS FEQEWKISSD
ESPRHPGRSG SGTQHCHCSS TSSQSEAADQ SMGYVSDSSC NSSDGVLVTF STLYNKMHGS
SRANLNSVPQ SCSDSSFCSH ADPGAFYLDL QPSPAESRMS CESHHPENGD REEGCGCPHV
SSPELDANCN AYRPHSEPCP AVADLTACFQ SQARLVVATQ NYYKLVTCDL SSQSSPSPAG
SSITSCSEEH TKISPPPGPC SDPDPNQPSE YYLFQKPDIQ PEEQEAVGSP AEAATAMGPT
VLEGQVYTNT SPPNLNTGRQ RSRSYDRSLE RSPPVRLGSL ERMLSCPVRL SEGPAALAGP
ASPPRRVTSF AELAKGRKKA AGSGSPPLRA SVGDSSQEFS PIQEAQQDRA APLDEGTRCS
HSLPSLPLGP SLDLLGPEPW STPVCQGSQS SEMPLPSLRA AGQGPLAQLM DPGPAFSGSP
ANSHTQRDAR ARADGGGTES RPVLRYSKEQ RPTTLPIQPF VFQHHFPKQL AKARALHSLS
QLYSLSGCSR AQQPAPLVIS TAQGPAPAPS GEPQPFTSQA SGRGARNAGP EPETSRPSPL
GSYSPVRSAG PFGSSTDSSA STSCSPPPEQ GAAADSVSPW SHTCPPTVRP ATSQQPPKED
QKIPTLAEYR LHGTGSLPPL GSWRSGFTRA ESLVRGGGEG SMANRPNNAN HLSPQALKWR
EYRRKNPLGP PGLSGSLDRR PPEARLARRN PIFEFPGSFG TTSHLNCRLN GQISKPLSLT
CPDLQDPFSL TEKPPAEFCL SPDGNSEAIS IDILQKKGLV KAVNTAVDLI VAHFGTSRDP
GVKAKLGNSS VSPNVGHLVL KYLCPAVQAV LEDGLKAFVL DVIIGQRKNM PWSVVEASTQ
LGPSTKVLHG LYNKVSQFPE LTSHTMRFNA FILGLLNIRS LEFWFNHLYN HEDIIQTHYQ
PWGFLRAAHT VCPGLFEELL LLLQPLALLP FSLDLLFQHR LLQSGRQQRQ HKELLRVSQD
LLLSAHSTLQ LARSRGQEGP GDMDRVAPGE RVKGVGASEG GEEDEEDAEE VAVVAGSSDH
GKWARGGQAG WWYQLMQSSQ VYIDGTAEGS RFPRSSSSGS GSEKKKGVGS GGPSQAPPPP
PREGVVEGAE ACPAPEEALG QERGWPFWMG SPPDSVLAEL RRSREREGPV APPTENEEGT
AEPSPGGIKW GHLFGSRKSQ REARPTNRLP SDWLSLDKSV FQLVAQTMGA RREPEPRENL
QESHPPAVPS KPPCEVQALC HHLATGPGQL SFHKGDVLRV LGPAGGDWLR CSRGPDTGLV
PLAYVTLTPT PSSPPGSSQN
//
