ID B2RUQ7_MOUSE Unreviewed; 982 AA.
AC B2RUQ7;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 08-NOV-2023, entry version 116.
DE SubName: Full=NLR family, pyrin domain containing 4A {ECO:0000313|EMBL:AAI41343.1};
GN Name=Nlrp4a {ECO:0000313|EMBL:AAI41343.1,
GN ECO:0000313|MGI:MGI:2443697};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI41343.1};
RN [1] {ECO:0000313|EMBL:AAI41343.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI41343.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; BC141342; AAI41343.1; -; mRNA.
DR EMBL; BC141343; AAI41344.1; -; mRNA.
DR RefSeq; NP_766484.1; NM_172896.2.
DR RefSeq; XP_011248868.1; XM_011250566.1.
DR AlphaFoldDB; B2RUQ7; -.
DR SMR; B2RUQ7; -.
DR PeptideAtlas; B2RUQ7; -.
DR DNASU; 243880; -.
DR GeneID; 243880; -.
DR KEGG; mmu:243880; -.
DR AGR; MGI:2443697; -.
DR CTD; 243880; -.
DR MGI; MGI:2443697; Nlrp4a.
DR VEuPathDB; HostDB:ENSMUSG00000040601; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR OMA; EEQQAWD; -.
DR OrthoDB; 55870at2759; -.
DR BioGRID-ORCS; 243880; 0 hits in 75 CRISPR screens.
DR ChiTaRS; Nlrp4a; mouse.
DR ExpressionAtlas; B2RUQ7; baseline and differential.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF9; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 4A; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}.
FT DOMAIN 1..93
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 148..282
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 982 AA; 112601 MW; 6E2DBCFEA2053585 CRC64;
MASFFSDFGL MWYLEELNKK EFVKFKEFLK QEVLQLGLKQ VSWTEVKKAS RQDLASLLLK
HYEEKPAWDM TFRFFQKINR KDLIERAKRE IDGCPKLYRA HMKTKMTHDS SRAFTISIQN
FLKEKFTEDD YDCFENLFQS KGTESKPQVV FLSGGAGVGK TLMLKRLMLA WIESPVFLHK
FSYIFYFCCR EVKQLKTASL AELISREWPG PSAPIEEILS KPEKLLFIID SLEGMECDLF
KWESELCDNC TEKQPVNVLL SSLLRRKMLP ESSLLISATP ESFEKMENRI EYTHVKIIKG
LKERNIKMSF HRLFQDRNRA HEAFSLVREN EQLFTVCQVP VLCWMVATCL KEEIEKGRDP
VSICRCTTSL YTTHIFNLFI PQNAHSPSKK SQDQLQGLCS LAAEGMWTDT FVFGEEALRR
NGIMDSDIPI LLDIGMLINI RESEKSYIFL HPSVQEVCAA IFYLLKSHVD HPSQEVKSIE
KLMFAFLKKV KVQWIFFGSF IFGLLHESEQ KKLEAFFGHQ LSQEIKRQLY QCLETISGNE
ELQEQIDGMK LFYCLFEMDD DTFLVEAMNC MEQINFVAKD YSDVIVAAHC LKHCFTLKKL
SFSTQNVLSG AQEHSYMERL LTAWNHICSV FIISKDIQEL RMKDTNLSES AFSVLYNNLK
YHNYTLNVLV ANNVFFVCEK YLFFELIQNC NLQHLNLSLT ILSHSDVKLL CDVLSQAECN
IEELVVAACS ISSDDCKVFA SVLISNKTLK HLNLASNTLD KGIASLCKSL CHPDCILEHL
VLANCSLNEK CWDYLSEVLR RNKTLSHLDI SSNDLKDEGL KVLCRALTLP DSVLKSLSLR
HCLITISGCQ DLAEVLRNNQ NLVSLQVSNN KLEDTGVKLL CDAIKHPNCH LEDLGLEACE
LTGACCEDLA STFTQCKTLW AMNLLKNALD YNGLVVLCEA LKQQTCATYV LGLQITDFDT
ETQAFLVAEQ EKNPCLRILS SL
//
