ID B2RWZ1_MOUSE Unreviewed; 339 AA.
AC B2RWZ1;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Src kinase-associated phosphoprotein 1 {ECO:0000256|ARBA:ARBA00039670};
GN Name=Skap1 {ECO:0000313|EMBL:AAI50765.1, ECO:0000313|MGI:MGI:1925723};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI50765.1};
RN [1] {ECO:0000313|EMBL:AAI50765.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI50765.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SKAP family.
CC {ECO:0000256|ARBA:ARBA00005864}.
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DR EMBL; BC145402; AAI45403.1; -; mRNA.
DR EMBL; BC150764; AAI50765.1; -; mRNA.
DR RefSeq; NP_001171370.1; NM_001177899.1.
DR AlphaFoldDB; B2RWZ1; -.
DR DNASU; 78473; -.
DR GeneID; 78473; -.
DR AGR; MGI:1925723; -.
DR CTD; 8631; -.
DR MGI; MGI:1925723; Skap1.
DR OrthoDB; 2968233at2759; -.
DR BioGRID-ORCS; 78473; 0 hits in 75 CRISPR screens.
DR ChiTaRS; Skap1; mouse.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd13380; PH_Skap1; 1.
DR CDD; cd12044; SH3_SKAP1; 1.
DR Gene3D; 6.10.250.220; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035765; SKAP1_SH3.
DR InterPro; IPR037781; SKAP_fam.
DR PANTHER; PTHR15129:SF1; SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 1; 1.
DR PANTHER; PTHR15129; SRC-ASSOCIATED ADAPTOR PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 107..210
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 274..335
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 64..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..239
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 39093 MW; E27FB13F0F4613C9 CRC64;
MQAVALPEEI CWLLEDTEDF LAEGLQNENL SPGAQDQRAH ILRGFQQIKS RYCWDFQPQG
GDLGQDGSDD NLSGTHGPPL TSEASFWSDY QDEGIEDILR GAQELDSVIK QGYLEKKSKD
HSFFGSEWQK RWCVISRGLF LYYANEKSKQ PKGTFLIKGY SVRMAPHLRK DSKKESCFEL
ISQDRRSYEF TSSSPAEARD WVDQISFLLK DLSSLTIPFE EEEEEEEEEE KEEEEMYNDV
DGFDSPRSGS QCRAMALPEP TEKEEDIYEV LPVDYADYYQ GLWDCHGDQP DELSFQRGDL
IRILSKEYNM YGWWVGELNS VIGIVPKDYL TTAFEMEGI
//
