ID B2RZE7_XENTR Unreviewed; 249 AA.
AC B2RZE7;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=pancreatic elastase {ECO:0000256|ARBA:ARBA00039015};
DE EC=3.4.21.36 {ECO:0000256|ARBA:ARBA00039015};
DE Flags: Fragment;
GN Name=LOC100170431 {ECO:0000313|EMBL:AAI67128.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI67128.1};
RN [1] {ECO:0000313|EMBL:AAI67128.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=N6 {ECO:0000313|EMBL:AAI67128.1};
RC TISSUE=Spleen {ECO:0000313|EMBL:AAI67128.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins, including elastin. Preferential
CC cleavage: Ala-|-Xaa.; EC=3.4.21.36;
CC Evidence={ECO:0000256|ARBA:ARBA00036864};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
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DR EMBL; BC167128; AAI67128.1; -; mRNA.
DR AlphaFoldDB; B2RZE7; -.
DR MEROPS; S01.153; -.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24257; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR24257:SF0; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 1; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Serine protease {ECO:0000256|RuleBase:RU363034}.
FT DOMAIN 13..249
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAI67128.1"
SQ SEQUENCE 249 AA; 26014 MW; 0E18FFDA055CA560 CRC64;
SGNLRFLEEN SRVVGGTNAS PNSWPWQISL QIQSGSGFSH TCGGSLIRTD RVLTAAHCVD
RAGPFRVILG EHNLSVNEGP EQIIAVSKIV KHVNWNPNNV AAGWDIALLY LASSASLNSN
VQLASLPSNG AILAHNSPCI ITGWGRTVTN GPLPAILQQA PLPSVAHATC STSSYWGSTV
KTSMVCAGGD GVTAGCNGDS GGPLNCPNNG VYEVHGIASF VSSLGCNAYL KPTVFTRVSA
YIDWINSNI
//
