ID B2UG73_RALPJ Unreviewed; 304 AA.
AC B2UG73;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:ACD28600.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:ACD28600.1};
GN OrderedLocusNames=Rpic_3480 {ECO:0000313|EMBL:ACD28600.1};
OS Ralstonia pickettii (strain 12J).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Ralstonia.
OX NCBI_TaxID=402626 {ECO:0000313|EMBL:ACD28600.1};
RN [1] {ECO:0000313|EMBL:ACD28600.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=12J {ECO:0000313|EMBL:ACD28600.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C.,
RA Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Marsh T., Richardson P.;
RT "Complete sequence of chromosome1 of Ralstonia pickettii 12J.";
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001068; ACD28600.1; -; Genomic_DNA.
DR AlphaFoldDB; B2UG73; -.
DR STRING; 402626.Rpic_3480; -.
DR KEGG; rpi:Rpic_3480; -.
DR PATRIC; fig|402626.5.peg.4613; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_0_4; -.
DR OMA; METPYPK; -.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006398; Tartro_sem_red.
DR NCBIfam; TIGR01505; tartro_sem_red; 1.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:ACD28600.1}.
FT DOMAIN 8..172
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 175..294
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 181
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 304 AA; 31448 MW; 7B1318104F6D5C5F CRC64;
MATATLNLGF IGLGIMGAPM AGHLRAAGHT LFVHDVNPAP AALVEAGVTV CTSAEEVAKR
ADIIFIMVPD TPHVEAVLFS EKGVAKALKD AGKDAAASKI VVDMSSISPI ATKDFAARIN
KTGAQYLDAP VSGGEVGAKA ASLTIMVGGE QAAFDRVAPL FNLMGKNITL VGGNGDGQTT
KVANQIIVAL NIQAVSEALL FASKAGADPA KVRQALMGGF AASRILEVHG ERMVKRTFDP
GFRIELHQKD LNLALQGAKT LGVALPNTAT AQELFNTCAA NGMGKQDHSA LCRAIEIMSN
HDIA
//