ID B2WUP2_CHICK Unreviewed; 534 AA.
AC B2WUP2;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Suppressor of cytokine signaling 6 {ECO:0000313|EMBL:ABQ53624.1, ECO:0000313|Ensembl:ENSGALP00010001382.1};
GN Name=SOCS6 {ECO:0000313|EMBL:ABQ53624.1,
GN ECO:0000313|Ensembl:ENSGALP00010001382.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ABQ53624.1};
RN [1] {ECO:0000313|EMBL:ABQ53624.1}
RP NUCLEOTIDE SEQUENCE.
RA Jin H.;
RT "Evolution of the suppressor of cytokine signaling (SOCS) family.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGALP00010001382.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010001382.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; EF544593; ABQ53624.1; -; mRNA.
DR RefSeq; NP_001120784.1; NM_001127312.1.
DR RefSeq; XP_015137876.1; XM_015282390.1.
DR RefSeq; XP_015137877.1; XM_015282391.1.
DR STRING; 9031.ENSGALP00000036145; -.
DR PaxDb; 9031-ENSGALP00000036145; -.
DR Ensembl; ENSGALT00010002832.1; ENSGALP00010001382.1; ENSGALG00010001225.1.
DR Ensembl; ENSGALT00010002833.1; ENSGALP00010001383.1; ENSGALG00010001225.1.
DR Ensembl; ENSGALT00010002834.1; ENSGALP00010001384.1; ENSGALG00010001225.1.
DR Ensembl; ENSGALT00010002835.1; ENSGALP00010001385.1; ENSGALG00010001225.1.
DR Ensembl; ENSGALT00010002836.1; ENSGALP00010001386.1; ENSGALG00010001225.1.
DR Ensembl; ENSGALT00010002837.1; ENSGALP00010001387.1; ENSGALG00010001225.1.
DR Ensembl; ENSGALT00010002838.1; ENSGALP00010001388.1; ENSGALG00010001225.1.
DR Ensembl; ENSGALT00010002839.1; ENSGALP00010001389.1; ENSGALG00010001225.1.
DR Ensembl; ENSGALT00010002840.1; ENSGALP00010001390.1; ENSGALG00010001225.1.
DR Ensembl; ENSGALT00010002841.1; ENSGALP00010001391.1; ENSGALG00010001225.1.
DR GeneID; 421020; -.
DR KEGG; gga:421020; -.
DR CTD; 9306; -.
DR VEuPathDB; HostDB:geneid_421020; -.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000154847; -.
DR HOGENOM; CLU_038160_0_0_1; -.
DR OMA; TPWPLRS; -.
DR OrthoDB; 5401079at2759; -.
DR TreeFam; TF321368; -.
DR Reactome; R-GGA-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000013731; Expressed in colon and 12 other cell types or tissues.
DR GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0050868; P:negative regulation of T cell activation; IEA:Ensembl.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0040008; P:regulation of growth; IEA:Ensembl.
DR CDD; cd10387; SH2_SOCS6; 1.
DR CDD; cd03740; SOCS_SOCS6; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035865; SOCS6_SH2.
DR InterPro; IPR037345; SOCS6_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF28; SUPPRESSOR OF CYTOKINE SIGNALING 6; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 383..490
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 485..534
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 54..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 59837 MW; 1FD09F8848FE2E6C CRC64;
MKKISLKTIR KSFNLNKSKD ESDFVVVQQP SLSEFGKDDS LFGSCYGKDL ASCEVNSEDE
KGGKNRSKSE SLMGTLKRRL SAKQKQKGKG STPSGSSADD DTFSSSSAPI TFKDVRAQRP
LRSTSLRNHH YSPTPWPLRP TNSEETCIKM EVKVKALVHS SNPSPALNGV RKDFHDLQSD
NVFQEQNNAL KNTESQNGDL HLHIDEHVPV VIGLMPQDYI QYTVPLDEGM YPLEGSRSYC
LDSSSPMEVS TVSSQVGENA FHEEESQVDQ DVVVAPDIFV DQAVNGLLIG TTGVVLQNPR
VNHSDVPPLS PLLPPMQNNQ IQRNFNGLNG TDAHVAESMR CHLNFDPNTA PGVGRVYDSV
QNSGPMVVTS LTEELKKLAK QGWYWGPITR WEAEGKLANV PDGSFLVRDS SDDRYLLSLS
FRSHGKTLHT RIEHSNGRFS FYEQPDVEGH TSIVDLIEHS IRDSENGAFC YSRSRLPGSA
TYPVRLTNPV SRFMQVRSLQ YLCRFVIRQY TRIDLIQKLP LPNKMKDYLQ EKHY
//
