ID B2X2G5_9HIV1 Unreviewed; 704 AA.
AC B2X2G5;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ABU79795.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABU79795.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABU79795.1}
RP NUCLEOTIDE SEQUENCE.
RA Borggren M., Repits J., Kuylenstierna C., Sterjovski J., Churchill M.J.,
RA Purcell D.F., Karlsson A., Albert J., Gorry P.R., Jansson M.;
RT "Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-1 variants
RT emerging during AIDS progression.";
RL Retrovirology 5:28-28(2008).
RN [2] {ECO:0000313|EMBL:ABU79795.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18672260; DOI=10.1016/j.virol.2008.06.014;
RA Repits J., Sterjovski J., Badia-Martinez D., Mild M., Gray L.,
RA Churchill M.J., Purcell D.F., Karlsson A., Albert J., Fenyo E.M.,
RA Achour A., Gorry P.R., Jansson M.;
RT "Primary HIV-1 R5 isolates from end-stage disease display enhanced viral
RT fitness in parallel with increased gp120 net charge.";
RL Virology 379:125-134(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; EF600086; ABU79795.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 2.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ABU79795.1};
KW Virion {ECO:0000313|EMBL:ABU79795.1}.
FT TRANSMEM 462..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..100
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 108..461
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 480..669
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 669..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABU79795.1"
FT NON_TER 704
FT /evidence="ECO:0000313|EMBL:ABU79795.1"
SQ SEQUENCE 704 AA; 79361 MW; 6C605F0CCBE4FCBC CRC64;
VYYGVPVWKE ATTTLFCASD ARAYDTEVHN VWVTHACVPT DPSPQEVVLE NVTENFNMWK
NDMVEQMHED IISLWDQSLK PCVKLTPLCV NLNCTDVNTT SSNGTIIERG EIKNCSFNIT
TSIRGKVKES AYFNKLDVVP IDNDNTSYRL ISCNTTVITQ ACPKVSFEPI PIHYCAPAGY
AILKCNNKTF NGTGPCTNVS TVQCTHGIRP VVSTQLLLNG SLAEEEVVIR SENFTDNAKT
IIVQLNKSVE INCIRPNNNT RQGIHIGPGK ALYTTKIIGN IRQAHCNISE TKWNNTLKQI
VEKLREQFGN KTIVFNQSSG GDPEIVTHSF NCGGEFFYCD STQLFNSTWI WNGTEGTNNT
ERNITLPCKI KQIINMWQKV GKAMYAPPIR GQIRCSSNIT GLLLTRDGGK DENTTEIFRP
GGGNMRDNWR SELYKYKVVR IEPLGVAPTK AKRRVVQREK RAVGLGAVFI GFLGAAGSTM
GAASITLTVQ ARQLLSGIVQ QQNNLLRAIE AQQHLLQLTV WGIKQLQARV LAVERYLKDQ
QLLGIWGCSG KLICTTTVPW NTSWSNKSYD YIWHNMTWME WEREIDNYTG LIYTLIEKSQ
NQQEKNEQEL LELDKWASLW SWFDITNWLW YIKIFIMIVG GLVGLRIVFV VLSIVNRVRQ
GYSPLSFQTH LPAPRGPDRP EGIEEEGGER DRDRSGRLVN GSLA
//
