ID B2X2I7_9HIV1 Unreviewed; 712 AA.
AC B2X2I7;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ABU79817.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABU79817.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABU79817.1}
RP NUCLEOTIDE SEQUENCE.
RA Borggren M., Repits J., Kuylenstierna C., Sterjovski J., Churchill M.J.,
RA Purcell D.F., Karlsson A., Albert J., Gorry P.R., Jansson M.;
RT "Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-1 variants
RT emerging during AIDS progression.";
RL Retrovirology 5:28-28(2008).
RN [2] {ECO:0000313|EMBL:ABU79817.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18672260; DOI=10.1016/j.virol.2008.06.014;
RA Repits J., Sterjovski J., Badia-Martinez D., Mild M., Gray L.,
RA Churchill M.J., Purcell D.F., Karlsson A., Albert J., Fenyo E.M.,
RA Achour A., Gorry P.R., Jansson M.;
RT "Primary HIV-1 R5 isolates from end-stage disease display enhanced viral
RT fitness in parallel with increased gp120 net charge.";
RL Virology 379:125-134(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; EF600108; ABU79817.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ABU79817.1};
KW Virion {ECO:0000313|EMBL:ABU79817.1}.
FT TRANSMEM 470..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..469
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 488..676
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 676..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..706
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABU79817.1"
FT NON_TER 712
FT /evidence="ECO:0000313|EMBL:ABU79817.1"
SQ SEQUENCE 712 AA; 80079 MW; 1DB67A44DBA5F7A9 CRC64;
VYYGVPVWKE ATTTLFCASD AKAYNTEKHN VWATHACVPT DPNPQEVVLE NVTEQFNMWK
NNMVEQMHED IISLWDQSLK PCVKLTPLCV TLNCTNVKNA TNTTSSREGL MEEGEIKNCS
FNITTNIRDK IQKVYALFYK LDVVPIDNDT TRYRLISCNT SVITQACPKV SFEPIPIHYC
TPAGFAILQC NDKKFDGKGP CKNVSTVQCT HGIRPVVSTQ LLLNGSLAEE EVVIRSDNFT
DNAKTIIVQL KEAVEINCTR PNNNTRKSIH IGPGRAFFAT GDIIGDIRQA HCNISKAKWN
TTLEQVVKKL REKFGNKTIV FNQSSGGDPE IVMHSFNCGG EFFYCNTTQL FNSTWNVNGT
EGSNNPGGEN ITLPCKIKQI VNMWQEVGKA MYAPPIRGQI RCSSNITGLL LTRDGGNNNT
EKREIFRPGG GDMRDNWRSE LYKYKVVRIK PLGVAPTKAK RRVVQREKRA VGIGALFLGF
LGAAGSTMGA ASMTLTVQAR LLLSGIVQQQ NNLLRAIEAQ QHLLQLTVWG IKQLQARVLA
VERYLKDQQL LGIWGCSGKL ICTTAVPWNT SWSNKSLNQI WDNMTWMEWD REINNYTSLI
YTLIEESQNQ QEKNEQELLE LDKWASLWTW FNITDWLWYI KIFIMIVGGL VGLRIVFAVL
SIVNRVRQGY SPLSLQTHLP APRGPDRPGG IEEEGGKRDR DRSGRLVDGS LA
//
