ID B2YVR1_9HIV1 Unreviewed; 861 AA.
AC B2YVR1;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ACD40529.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACD40529.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACD40529.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1056.08_6 {ECO:0000313|EMBL:ACD40529.1};
RX PubMed=18490657; DOI=10.1073/pnas.0802203105;
RA Keele B.F., Giorgi E.E., Salazar-Gonzalez J.F., Decker J.M., Pham K.T.,
RA Salazar M.G., Sun C., Grayson T., Wang S., Li H., Wei X., Jiang C.,
RA Kirchherr J.L., Gao F., Anderson J.A., Ping L.H., Swanstrom R.,
RA Tomaras G.D., Blattner W.A., Goepfert P.A., Kilby J.M., Saag M.S.,
RA Delwart E.L., Busch M.P., Cohen M.S., Montefiori D.C., Haynes B.F.,
RA Gaschen B., Athreya G.S., Lee H.Y., Wood N., Seoighe C., Perelson A.S.,
RA Bhattacharya T., Korber B.T., Hahn B.H., Shaw G.M.;
RT "Identification and characterization of transmitted and early founder virus
RT envelopes in primary HIV-1 infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:7552-7557(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; EU578735; ACD40529.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR HAMAP; MF_04083; HIV_ENV; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR037527; Gp160.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Clathrin-mediated endocytosis of virus by host
KW {ECO:0000256|ARBA:ARBA00022570};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ACD40529.1};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022570};
KW Virion {ECO:0000313|EMBL:ACD40529.1};
KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00022570}.
FT TRANSMEM 683..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..515
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 534..724
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 723..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACD40529.1"
SQ SEQUENCE 861 AA; 98010 MW; 90429D1BBAE4E866 CRC64;
MEIRKNYQHL WRWGIMLLWL LMSCSAEEEA WVTVYYGVPV WKEAVTTLFC ASDAKAYDTE
VHNVWTTHAC VPTDPDPQEV HMENVTEDFN MWKNNMADQM HEDIISLWDQ SLKPCVKLTP
LCVTLNCADW KNNTDTNTNS SVRIMEKGEI KNCSFNITTN IRDKYQKAYA LFYKLDVVPI
DDDNATGNND TRNYRLISCN TSVITQACPK VSFEPIPIHY CAPAGFAILR CNNKTFSGKG
QCTNVSTVQC THGIKPVVST QLLLNGSLAE EEVIIRSDNF SDNAKTIIVH LNSSVDINCT
RPGNNTRKSI TIGPGRAFYA TGDIIGDIRQ AHCNISGEKW NNTLKQVVKK LREQFGNKTI
VFNQSSGGDP EITMHTFNCG GEFFYCNTAQ LFNSTWEANS TWENDNERVG HSNKTIILQC
RIKQIINMWQ EVGKAMYAPP ISGQIRCSSN ITGLLLTRDG GNGNETNRTE VFRPGGGNMK
DNWRSELYKY KVVKIEPLGV APTRAKRRVV QREKRTVGMG ALFIGFLSAA GSTMGAASMT
LTVQARQLLS GIVQQQSNLL RAIEAQQHLL QLTVWGIKQL QARVLAVERY LKDQQLLGIW
GCSGKLICTT TVPWNYSWSP NKTMDDIWGN MTWMQWEREI DNYTGIIYRL IEISQNQQEK
NEQELLELDK WASLWNWFDI TKWLWYIKIF IMIIGGLVGL RIVFTVLSIV NRVRQGYSPL
SFQTRFPAPG GPDRPEGTEE EGGERDRDRS SRSADGFLAI IWVDLRSLCL FIYHSLRDLL
LIVARIVGLL GRRGWELLKY WWNLLQYWSQ ELKNSAVSLL NATAIAVAEG TDRVIDIVQR
ICRAILHIPR RIRQGFERAL L
//
