ID B2ZFP6_RHOER Unreviewed; 388 AA.
AC B2ZFP6;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Rieske-type oxygenase {ECO:0000256|ARBA:ARBA00030944};
GN Name=kshA2 {ECO:0000313|EMBL:ACD11366.1};
OS Rhodococcus erythropolis (Arthrobacter picolinophilus).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus; Rhodococcus erythropolis group.
OX NCBI_TaxID=1833 {ECO:0000313|EMBL:ACD11366.1};
RN [1] {ECO:0000313|EMBL:ACD11366.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SQ1 {ECO:0000313|EMBL:ACD11366.1};
RX PubMed=18836008; DOI=10.1128/AEM.00888-08;
RA van der Geize R., Hessels G.I., Nienhuis-Kuiper M., Dijkhuizen L.;
RT "Characterization of a second Rhodococcus erythropolis SQ1 3-ketosteroid
RT 9alpha-hydroxylase activity comprising a terminal oxygenase homologue,
RT KshA2, active with oxygenase-reductase component KshB.";
RL Appl. Environ. Microbiol. 74:7197-7203(2008).
RN [2] {ECO:0000313|EMBL:ACD11366.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SQ1 {ECO:0000313|EMBL:ACD11366.1};
RA Van der Geize R., Dijkhuizen L.;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
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DR EMBL; EU656136; ACD11366.1; -; Genomic_DNA.
DR AlphaFoldDB; B2ZFP6; -.
DR BRENDA; 1.14.15.30; 5389.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProt.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd03531; Rieske_RO_Alpha_KSH; 1.
DR Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR InterPro; IPR045605; KshA-like_C.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR PANTHER; PTHR21266:SF61; 3-KETOSTEROID-9-ALPHA-MONOOXYGENASE, OXYGENASE COMPONENT; 1.
DR PANTHER; PTHR21266; IRON-SULFUR DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF19298; KshA_C; 1.
DR Pfam; PF00355; Rieske; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF50022; ISP domain; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 4: Predicted;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221}.
FT DOMAIN 34..136
FT /note="Rieske"
FT /evidence="ECO:0000259|PROSITE:PS51296"
SQ SEQUENCE 388 AA; 44117 MW; C16B9CD5E9A19380 CRC64;
MLTTDVTTTT DLGEVDEIRM IDEGRAPERF ARGWHCLGLA TDFHDGNPHP IEPFGTKLVV
FADSQSELKV LDAYCRHMGG DLSQGTVKGD SVACPFHDWR WGGNGKCTAI PYARRVPPLA
KTRAWTTLEQ DGLLFVWHDP EGNPPPAEVA IPVIKTPDHE WTDWVWKSIV IDTNCREIVD
NVVDMAHFFY VHFSFPTYFK NVFEGHVAIQ EQSGINRDDI VTWTDPDVPQ LVSNFSVAAY
HGPSFMIDDL VYQYETFKVD SVLINCHYPV SPNKFVLMYG ITVKKTEELP AGIADQTVDA
MIGYIGVGFE QDIEIWKNKT RIDNPLLCTE DGPVYQLRRW YEQFYVDVAD VTPEMIDRFE
FEMDTSKPIE VWKQEVADNI ARRAGAAQ
//
