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Database: UniProt
Entry: B2ZGK8_AEGTA
LinkDB: B2ZGK8_AEGTA
Original site: B2ZGK8_AEGTA 
ID   B2ZGK8_AEGTA            Unreviewed;      2311 AA.
AC   B2ZGK8;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   24-JAN-2024, entry version 84.
DE   RecName: Full=acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00013058};
DE            EC=6.4.1.2 {ECO:0000256|ARBA:ARBA00013058};
GN   Name=Acc-1 {ECO:0000313|EMBL:ACD46679.1};
OS   Aegilops tauschii (Tausch's goatgrass) (Aegilops squarrosa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX   NCBI_TaxID=37682 {ECO:0000313|EMBL:ACD46679.1};
RN   [1] {ECO:0000313|EMBL:ACD46679.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AL8/78 {ECO:0000313|EMBL:ACD46679.1};
RX   PubMed=18599450; DOI=10.1073/pnas.0803981105;
RA   Chalupska D., Lee H.Y., Faris J.D., Evrard A., Chalhoub B., Haselkorn R.,
RA   Gornicki P.;
RT   "Acc homoeoloci and the evolution of wheat genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:9691-9696(2008).
RN   [2] {ECO:0000313|EnsemblPlants:EMT24251}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=biotin; Xref=ChEBI:CHEBI:57586;
CC         Evidence={ECO:0000256|ARBA:ARBA00001953};
CC   -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC       acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
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DR   EMBL; EU660897; ACD46679.1; -; Genomic_DNA.
DR   EnsemblPlants; EMT24251; EMT24251; F775_20574.
DR   OMA; CLLLKEM; -.
DR   UniPathway; UPA00655; UER00711.
DR   ExpressionAtlas; B2ZGK8; baseline.
DR   GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd06850; biotinyl_domain; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 3.40.50.20; -; 1.
DR   Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR   Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR   InterPro; IPR049076; ACCA.
DR   InterPro; IPR049074; ACCA_BT.
DR   InterPro; IPR034733; AcCoA_carboxyl_beta.
DR   InterPro; IPR013537; AcCoA_COase_cen.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR005481; BC-like_N.
DR   InterPro; IPR011764; Biotin_carboxylation_dom.
DR   InterPro; IPR005482; Biotin_COase_C.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR45728:SF4; ACETYL-COA CARBOXYLASE 2; 1.
DR   PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR   Pfam; PF08326; ACC_central; 1.
DR   Pfam; PF21385; ACCA_BT; 1.
DR   Pfam; PF02785; Biotin_carb_C; 1.
DR   Pfam; PF00289; Biotin_carb_N; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   Pfam; PF02786; CPSase_L_D2; 1.
DR   SMART; SM00878; Biotin_carb_C; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 2.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR   SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR   SUPFAM; SSF51230; Single hybrid motif; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS50979; BC; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
DR   PROSITE; PS00867; CPSASE_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00409}.
FT   DOMAIN          131..638
FT                   /note="Biotin carboxylation"
FT                   /evidence="ECO:0000259|PROSITE:PS50979"
FT   DOMAIN          284..478
FT                   /note="ATP-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS50975"
FT   DOMAIN          765..839
FT                   /note="Lipoyl-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50968"
FT   DOMAIN          1551..1886
FT                   /note="CoA carboxyltransferase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50980"
FT   DOMAIN          1890..2206
FT                   /note="CoA carboxyltransferase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50989"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2311 AA;  254876 MW;  EAC10E4E46B453DC CRC64;
     MGSTHLPIVG LNASTTPSLS TIRPVNSAGA AFQPSAPSRT SKKKSRRVQS LRDGGDGGVS
     DPNQSIRQGL AGIIDLPKEG TSAPEVDISH GSEEPRGSYQ MNGILNEAHN GRHASLSKVV
     EFCMALGGKT PIHSVLVANN GMAAAKFMRS VRTWANETFG SEKAIQLIAM ATPEDMRINA
     EHIRIADQFV EVPGGTNNNN YANVQLIVEI AVRTGVSAVW PGWGHASENP ELPDALNANG
     IVFLGPPSSS MNALGDKVGS ALIAQAAGVP TLPWSGSQVE IPLEVCLDSI PADMYRKACV
     STTEEALASC QMIGYPAMIK ASWGGGGKGI RKVNNDDDVR ALFKQVQGEV PGSPIFIMRL
     ASQSRHLEVQ LLCDQYGNVA ALHSRDCSVQ RRHQKIIEEG PVTVAPRETV KELEQAARRL
     AKAVGYVGAA TVEYLYSMET GEYYFLELNP RLQVEHPVTE WIAEVNLPAA QVAVGMGIPL
     WQVPEIRRFY GMDNGGGYDI WRKTAALATP FNFDEVDSQW PKGHCVAVRI TSEDPDDGFK
     PTGGKVKEIS FKSKPNVWAY FSVKSGGGIH EFADSQFGHV FAYGVSRAAA ITNMSLALKE
     IQIRGEIHSN VDYTVDLLNA SDFKENRIHT GWLDNRIAMR VQAERPPWYI SVVGGALYKT
     ITSNTDTVSE YVSYLVKGQI PPKHISLVHS TVSLNIEESK YTIETIRSGQ GSYRLRMNGS
     VIEANVQTLC DGGLLMQLDG NSHVIYAEEE AGGTRLLIDG KTCLLQNDHD PSRLLAETPC
     KLLRFLVADG AHVEADVPYA EVEVMKMCMP LLSPAAGVIN VLLSEGQPMQ AGDLIARLDL
     DDPSAVKRAE PFNGSFPEMS LPIAASGQVH KRCATSLNAA RMVLAGYDHP INKVVQDLVS
     CLDAPELPFL QWEELMSVLA TRLPRLLKSE LEGKYSEYKL NVGHGKSKDF PSKMLREIIE
     ENLAHGSEKE IATNERLVEP LMSLLKSYEG GRESHAHFIV KSLFEDYLSV EELFSDGIQS
     DVIERLRQQH SKDLQKVVDI VLSHQGVRNK TKLILTLMEK LVYPNPAAYK DQLTRFSSLN
     HKRYYKLALK ASELLEQTKL SELRTSIARS LSELEMFTEE RTAISEIMGD LVTAPLPVED
     ALVSLFDCSD QTLQQRVIET YISRLYQPHL VKDSIQLKYQ ESGVIALWEF AEAHSEKRLG
     AMVIVKSLES VSAAIGAALK GTSRYASSEG NIMHIALLGA DNQMHGTEDS GDNDQAQVRI
     DKLSATLEQN TVTADLRAAG VKVISCIVQR DGALMPMRHT FLLSDEKLCY EEEPVLRHVE
     PPLSALLELG KLKVKGYNEV KYTPSRDRQW NIYTLRNTEN PKMLHRVFFR TLVRQPGASN
     KFTSGNISDV EVGGAEESLS FTSSSILRSL MTAIEELELH AIRTGHSHMF LCILKEQKLL
     DLVPVSGNKV VDIGQDEATA CLLLKEMALQ IHELVGARMH HLSVCQWEVK LKLDSDGPAS
     GTWRVVTTNV TSHTCTVDIY REVEDTESQK LVYHSAPSSS GPLHGVALNT PYQPLSVIDL
     KRCSARNNRT TYCYDFPLAF ETAVQKSWSN ISSDTNRCYV KATELVFAHK NGSWGTPVIP
     MERPAGLNDI GMVAWILDMS TPEYPNGRQI VVIANDITFR AGSFGPREDA FFETVTNLAC
     ERKLPLIYLA ANSGARIGIA DEVKSCFRVG WSDDGSPERG FQYIYLTEED HARISASVIA
     HKMQLDNGEI RWVIDSVVGK EDGLGVENIH GSAAIASAYS RAYEETFTLT FVTGRTVGIG
     AYLARLGIRC IQRTDQPIIL TGFSALNKLL GREVYSSHMQ LGGPKIMATN GVVHLTVSDD
     LEGVSNILRW LSYVPANIGG PLPITKSLDP PDRPVAYIPE NTCDPRAAIS GIDDSQGKWL
     GGMFDKDSFV ETFEGWAKSV VTGRAKLGGI PVGVIAVETQ TMMQLIPADP GQLDSHERSV
     PRAGQVWFPD SATKTAQAML DFNREGLPLF ILANWRGFSG GQRDLFEGIL QAGSTIVENL
     RTYNQPAFVY IPKAAELRGG AWVVIDSKIN PDRIEFYAER TAKGNVLEPQ GLIEIKFRSE
     ELQECMGRLD PELINLKAKL LGAKHENGSL SESESLQKSI EARKKQLLPL YTQIAVRFAE
     LHDTSLRMAA KGVIKKVVDW EDSRSFFYKR LRRRISEDVL AKEIRGVSGK QFSHQSAIEL
     IQKWYLASKG AETGNTEWDD DDAFVAWREN PENYQEYIKE LRAQRVSQLL SDVADSSPDL
     EALPQGLSML LEKMDPSRRA QFVEEVKKAL K
//
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