ID   B3BWS7_ECO57            Unreviewed;       251 AA.
AC   B3BWS7;
DT   22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 1.
DT   03-APR-2013, entry version 17.
DE   RecName: Full=CDP-diacylglycerol pyrophosphatase;
DE            EC=3.6.1.26;
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase;
DE   AltName: Full=CDP-diglyceride hydrolase;
GN   Name=cdh; ORFNames=ECH7EC508_4924;
OS   Escherichia coli O157:H7 str. EC508.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=478007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EC508;
RA   Eppinger M., Ravel J., Mammel M.K., LeClerc J.E., Cebula T.A.,
RA   Sebastian Y.;
RT   "Annotation of Escherichia coli O157:H7 str. EC508.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EC508;
RA   Rosovitz M.J., Ravel J.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: CDP-diacylglycerol + H(2)O = CMP +
CC       phosphatidate.
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the cdh family.
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DR   EMBL; ABHW01000012; EDU96519.1; -; Genomic_DNA.
DR   ProteinModelPortal; B3BWS7; -.
DR   SMR; B3BWS7; 31-250.
DR   EnsemblBacteria; EDU96519; EDU96519; ECH7EC508_4924.
DR   PATRIC; 29355206; VBIEscCol61748_2243.
DR   OMA; INSRWSP; -.
DR   UniPathway; UPA00609; UER00664.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00319; Cdh; 1; -.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase.
DR   InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   TIGRFAMs; TIGR00672; cdh; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Lipid biosynthesis; Lipid metabolism;
KW   Membrane; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Transmembrane; Transmembrane helix.
FT   TRANSMEM      4     24       Helical; (By similarity).
SQ   SEQUENCE   251 AA;  28383 MW;  C987D3A4B12BE5F3 CRC64;
     MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ NPSPCAEVKP
     NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQARDF MSKKYGQPVP
     DRAVSLAINS RTGRTQNHFH IHISCIRPDV REQLDNNLAN ISSRWLPLPG GLRGHEYLAR
     RVTESELVQR SPFMMLAEEV PEAREHMGSY GLAMVRQSDN SFVLLATQRN LLTLNRASAE
     EIQDHQCEIL R
//