ID B3DH97_DANRE Unreviewed; 315 AA.
AC B3DH97; A0A8M1NIP7;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Odorant receptor, family H, subfamily 136, member 1 {ECO:0000313|Ensembl:ENSDARP00000072288, ECO:0000313|RefSeq:NP_001129719.1};
GN Name=or90h4 {ECO:0000313|ZFIN:ZDB-GENE-070806-23};
GN Synonyms=or136-1 {ECO:0000313|RefSeq:NP_001129719.1}, zgc:194103
GN {ECO:0000313|RefSeq:NP_001129719.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI62687.1};
RN [1] {ECO:0000313|RefSeq:NP_001129719.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16332259;
RA Alioto T.S., Ngai J.;
RT "The odorant receptor repertoire of teleost fish.";
RL BMC Genomics 6:173-173(2006).
RN [2] {ECO:0000313|EMBL:AAI62687.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000072288}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000072288};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000072288, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000072288};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001129719.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26108469;
RA Saraiva L.R., Ahuja G., Ivandic I., Syed A.S., Marioni J.C.,
RA Korsching S.I., Logan D.W.;
RT "Molecular and neuronal homology between the olfactory systems of zebrafish
RT and mouse.";
RL Sci. Rep. 5:11487-11487(2015).
RN [6] {ECO:0000313|RefSeq:NP_001129719.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26892307;
RA Calfun C., Dominguez C., Perez-Acle T., Whitlock K.E.;
RT "Changes in Olfactory Receptor Expression Are Correlated With Odor Exposure
RT During Early Development in the zebrafish (Danio rerio).";
RL Chem. Senses 41:301-312(2016).
RN [7] {ECO:0000313|RefSeq:NP_001129719.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX649282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC162687; AAI62687.1; -; mRNA.
DR RefSeq; NP_001129719.1; NM_001136247.1.
DR PaxDb; 7955-ENSDARP00000072288; -.
DR Ensembl; ENSDART00000077822.4; ENSDARP00000072288.2; ENSDARG00000105803.2.
DR GeneID; 556415; -.
DR KEGG; dre:556415; -.
DR AGR; ZFIN:ZDB-GENE-070806-23; -.
DR CTD; 556415; -.
DR ZFIN; ZDB-GENE-070806-23; or90h4.
DR eggNOG; ENOG502RXHR; Eukaryota.
DR HOGENOM; CLU_077059_0_0_1; -.
DR OMA; RITTTSM; -.
DR OrthoDB; 4031103at2759; -.
DR TreeFam; TF332078; -.
DR Proteomes; UP000000437; Chromosome 6.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0051378; F:serotonin binding; IBA:GO_Central.
DR GO; GO:0007198; P:adenylate cyclase-inhibiting serotonin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR CDD; cd00637; 7tm_classA_rhodopsin-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR26451; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR26451:SF975; ODORANT RECEPTOR-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:NP_001129719.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..288
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 315 AA; 35906 MW; 0093BC10BD6874AB CRC64;
MCSCLFSSTE MNTTVWIVDN YQEAITKHIV IVFLALIVNV INGMLVVTFF SSHVFSRDSR
YILYIHLVIN DMLMICASVA IYVLTYIAPV VNASLCYILM SLGKVFFMIT PLNLAGMAIE
RFIAVCKPLH HSQICTPQRT YVFFCLLWGI AAIRSVVDIM ISLLTQPISF FRSFVPCYPT
YMFPSKAHDD HNTASQVICM SMVWIIICYT YCRVLFAARK AVSKGSASKA RSTILLHGVQ
LLLCMLSYVT PFMYTLIIPL FPLQRTNIAF CIYVFTNIMP RLLSPLIYGV RDQKFIKQMK
EVFTCKVIFL KIVPS
//
