ID B3DJ49_DANRE Unreviewed; 538 AA.
AC B3DJ49; A0A2R8RL26; B3DJ60;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 24-JAN-2024, entry version 101.
DE RecName: Full=Frizzled-1 {ECO:0000256|ARBA:ARBA00018150};
GN Name=zgc:194774 {ECO:0000313|EMBL:AAI63369.1,
GN ECO:0000313|RefSeq:NP_001124086.1};
GN Synonyms=fz10 {ECO:0000313|RefSeq:NP_001124086.1}, fz3
GN {ECO:0000313|RefSeq:NP_001124086.1}, zg03
GN {ECO:0000313|RefSeq:NP_001124086.1}, zg10
GN {ECO:0000313|RefSeq:NP_001124086.1};
GN OrderedLocusNames=fzd1 {ECO:0000313|Ensembl:ENSDARP00000147690,
GN ECO:0000313|RefSeq:NP_001124086.1,
GN ECO:0000313|ZFIN:ZDB-GENE-990415-219};
GN ORFNames=zgc:194761 {ECO:0000313|EMBL:AAI63358.1,
GN ECO:0000313|RefSeq:NP_001124086.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI63369.1};
RN [1] {ECO:0000313|RefSeq:NP_001124086.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8626800; DOI=10.1074/jbc.271.8.4266;
RA Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J.,
RA Copeland N.G., Jenkins N.A., Nathans J.;
RT "A large family of putative transmembrane receptors homologous to the
RT product of the Drosophila tissue polarity gene frizzled.";
RL J. Biol. Chem. 271:4468-4476(1996).
RN [2] {ECO:0000313|EMBL:AAI63369.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001124086.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21911385;
RA Lu F.I., Thisse C., Thisse B.;
RT "Identification and mechanism of regulation of the zebrafish dorsal
RT determinant.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:15876-15880(2011).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000147690, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000147690};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001124086.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23349976;
RA Nikaido M., Law E.W., Kelsh R.N.;
RT "A systematic survey of expression and function of zebrafish frizzled
RT genes.";
RL PLoS ONE 8:e54833-e54833(2013).
RN [6] {ECO:0000313|RefSeq:NP_001124086.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26818140;
RA Coppola U., Annona G., D'Aniello S., Ristoratore F.;
RT "Rab32 and Rab38 genes in chordate pigmentation: an evolutionary
RT perspective.";
RL BMC Evol. Biol. 16:26-26(2016).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000147690}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000147690};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [8] {ECO:0000313|RefSeq:NP_001124086.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; LO018530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC163358; AAI63358.1; -; mRNA.
DR EMBL; BC163369; AAI63369.1; -; mRNA.
DR RefSeq; NP_001124086.1; NM_001130614.1.
DR STRING; 7955.ENSDARP00000147690; -.
DR PaxDb; 7955-ENSDARP00000111678; -.
DR Ensembl; ENSDART00000179533; ENSDARP00000147690; ENSDARG00000106062.
DR Ensembl; ENSDART00000179533.2; ENSDARP00000147690.1; ENSDARG00000106062.2.
DR GeneID; 557384; -.
DR KEGG; dre:557384; -.
DR CTD; 8321; -.
DR ZFIN; ZDB-GENE-990415-219; fzd1.
DR OMA; RLYGLMY; -.
DR OrthoDB; 5483535at2759; -.
DR Reactome; R-DRE-4086400; PCP/CE pathway.
DR Reactome; R-DRE-4608870; Asymmetric localization of PCP proteins.
DR Reactome; R-DRE-4641262; Disassembly of the destruction complex and recruitment of AXIN to the membrane.
DR Proteomes; UP000000437; Chromosome 16.
DR Bgee; ENSDARG00000106062; Expressed in zone of skin and 11 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042813; F:Wnt receptor activity; IBA:GO_Central.
DR GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0035567; P:non-canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd07458; CRD_FZ1_like; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF81; FRIZZLED-1; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001124086.1};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..538
FT /note="Frizzled-1"
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001124086.1"
FT /id="PRO_5035035022"
FT TRANSMEM 221..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..146
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 219..520
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 146..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 33..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 41..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 108..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 538 AA; 60405 MW; C1A9AAC4755FFA6C CRC64;
MAARALFLIA LGALSARAQY GDRGMSVPEH GFCQPISIPL CTDIAYNETI MPNLLGHTNQ
EDAGLEVHQF YPLVKVQCSP DLKFFLCSMY APVCTVLEQA LPPCRSLCER ARQGCEALMN
KFGFQWPESL ACESFPVHGG ELCVGQNTTG PSPPVSPTPD ATQAPPEPSQ RGRFQCPPSL
RVPPYLNYRF MGEDNCGAPC EPRKLHGMMY FSEDEQKFAR IWIGIWSVLC CASTLFTVLT
YLVDMKRFSY PERPIIFLSG CYTMVSIAYI AGFLLEDKVV CNEQFENEFR TVVQGTKKEG
CTILFMMLYF FSMSSSIWWV ILALTWFLAA GMKWGHEAIE ANSQYFHLAA WAVPAIKTIT
ILAVGQVDGD VLSGVCFVGI NSVDALRGFV LAPLFVYLFI GTSFLLAGFV SLFRIRTIMK
HDGTKTEKLE KLMVRIGIFS VLYTVPATIV IACYFYEQAF RAHWEQTWSA HSCKTYAVPC
PAHNPQMNPD FTVFMIKYLM TLIVGITSGF WIWSGKTLNS WRKFYTRLAN SKQGETTV
//