ID B3DJC9_DANRE Unreviewed; 687 AA.
AC B3DJC9;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Collagen alpha-1(IX) chain precursor {ECO:0000313|RefSeq:NP_001124096.1};
DE SubName: Full=Zgc:194937 protein {ECO:0000313|EMBL:AAI63438.1};
GN Name=col9a1a {ECO:0000313|ZFIN:ZDB-GENE-080721-25};
GN ORFNames=zgc:194937 {ECO:0000313|EMBL:AAI63438.1,
GN ECO:0000313|RefSeq:NP_001124096.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI63438.1};
RN [1] {ECO:0000313|EMBL:AAI63438.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:NP_001124096.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [4] {ECO:0000313|RefSeq:NP_001124096.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28385905;
RA Garcia G.R., Goodale B.C., Wiley M.W., La Du J.K., Hendrix D.A.,
RA Tanguay R.L.;
RT "In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required
RT for Proper Sox9b Expression.";
RL Mol. Pharmacol. 91:609-619(2017).
RN [5] {ECO:0000313|RefSeq:NP_001124096.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29405914;
RA Lopez-Baez J.C., Simpson D.J., LLeras Forero L., Zeng Z., Brunsdon H.,
RA Salzano A., Brombin A., Wyatt C., Rybski W., Huitema L.F.A., Dale R.M.,
RA Kawakami K., Englert C., Chandra T., Schulte-Merker S., Hastie N.D.,
RA Patton E.E.;
RT "Wilms Tumor 1b defines a wound-specific sheath cell subpopulation
RT associated with notochord repair.";
RL Elife 7:e30657-e30657(2018).
RN [6] {ECO:0000313|RefSeq:NP_001124096.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29499231;
RA He H., Wang C., Tang Q., Yang F., Xu Y.;
RT "Elucidation of possible molecular mechanisms underlying the estrogen-
RT induced disruption of cartilage development in zebrafish larvae.";
RL Toxicol. Lett. 289:22-27(2018).
RN [7] {ECO:0000313|RefSeq:NP_001124096.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC163438; AAI63438.1; -; mRNA.
DR RefSeq; NP_001124096.1; NM_001130624.1.
DR GeneID; 100170785; -.
DR KEGG; dre:100170785; -.
DR AGR; ZFIN:ZDB-GENE-080721-25; -.
DR CTD; 100170785; -.
DR ZFIN; ZDB-GENE-080721-25; col9a1a.
DR OrthoDB; 4270281at2759; -.
DR PhylomeDB; B3DJC9; -.
DR Proteomes; UP000000437; Chromosome 11.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IBA:GO_Central.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR InterPro; IPR008160; Collagen.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1100; FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 7.
PE 2: Evidence at transcript level;
KW Collagen {ECO:0000313|RefSeq:NP_001124096.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001124096.1}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..687
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001124096.1"
FT /id="PRO_5035035097"
FT REGION 32..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..563
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 65858 MW; ADB8501168E2054A CRC64;
MAHAGTLRAS LLLILLQLVL IISAQRGPVG PRGLPGPPGL PGFPGVDGID GERGPGPGPV
GPPGLDGDNG RNGLNGLPGK PGADGLTGPR GAPGPVGPTG QKGEPGEPGL RGAAGVGEDG
EAGADGDDGL PGEMGKVGPP GSRGVRGPVG DQGLPGPRGP PGVWDGKELC PNSCTSGLHG
YTGLPGMKGH KGVKGESGEP GRQGHKGEEG DQGRTGEQGT QGLPGKQGLR GITGLMGPKG
DRGPRGNVGD LGPQGIQGAP GDQGQRGKYG ETGPKGSQGP EGLQGLPGLP GPKGDAGLPA
VDARDGIPGL PGVKGLPGKV GSPGDAGLQG FPGLPGISGA KGHMGLKGST GDPGVAGPIG
NNGKTGERGE QGEVGPVGPR GGPGERGARG PDGPAGLPGA RGSKGDPGLP GLPGPAGFIG
QKGDRGAVGF TGPKGEQGPS GEEGAPGDKG DVGDEGEPGE KGSTGKQGDP GNKGPEGARG
QSGPDGPVGV PGPRGMQGDP GVPGLPGAQG KPGRAPTDEH IKQVCRRVLH GQLAQLAASL
TRPESGIAGL PGPPGPPGPP GSSGENGFPG HPGSRGLPGL KGPPGLLGRK GPKGDQGDRG
DRGPTAVGPK GIPGPPGLPG EPGKPAYGSN GRDGQRGPVG VPGMPGVPGP PGPPGLNGYC
ESSQCVLQAA AGQQSFKESN MKGPDAL
//
