ID B3DKI6_DANRE Unreviewed; 149 AA.
AC B3DKI6; A0A8M1NID2;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Solute carrier family 39 (Zinc transporter), member 4 {ECO:0000313|EMBL:AAI63862.1};
DE SubName: Full=Solute carrier family 39 member 4 {ECO:0000313|Ensembl:ENSDARP00000076900};
DE SubName: Full=Zinc transporter ZIP4 {ECO:0000313|RefSeq:NP_001124249.1};
GN Name=slc39a4 {ECO:0000313|EMBL:AAI63862.1,
GN ECO:0000313|Ensembl:ENSDARP00000076900,
GN ECO:0000313|RefSeq:NP_001124249.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060315-8};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI63862.1};
RN [1] {ECO:0000313|RefSeq:NP_001124249.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16500426;
RA Feeney G.P., Zheng D., Kille P., Hogstrand C.;
RT "The phylogeny of teleost ZIP and ZnT zinc transporters and their tissue
RT specific expression and response to zinc in zebrafish.";
RL Biochim. Biophys. Acta 1732:88-95(2005).
RN [2] {ECO:0000313|RefSeq:NP_001124249.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16689696;
RA Kambe T., Suzuki T., Nagao M., Yamaguchi-Iwai Y.;
RT "Sequence similarity and functional relationship among eukaryotic ZIP and
RT CDF transporters.";
RL Genomics Proteomics Bioinformatics 4:1-9(2006).
RN [3] {ECO:0000313|EMBL:AAI63862.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001124249.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21596156;
RA Ho E., Dukovcic S., Hobson B., Wong C.P., Miller G., Hardin K.,
RA Traber M.G., Tanguay R.L.;
RT "Zinc transporter expression in zebrafish (Danio rerio) during
RT development.";
RL Comp. Biochem. Physiol. C Toxicol. Pharmacol. 155:26-32(2012).
RN [5] {ECO:0000313|RefSeq:NP_001124249.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22912764;
RA Yan G., Zhang Y., Yu J., Yu Y., Zhang F., Zhang Z., Wu A., Yan X., Zhou Y.,
RA Wang F.;
RT "Slc39a7/zip7 plays a critical role in development and zinc homeostasis in
RT zebrafish.";
RL PLoS ONE 7:e42939-e42939(2012).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000076900}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000076900};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [7] {ECO:0000313|Ensembl:ENSDARP00000076900, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000076900};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|RefSeq:NP_001124249.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28837703;
RA Beaver L.M., Truong L., Barton C.L., Chase T.T., Gonnerman G.D., Wong C.P.,
RA Tanguay R.L., Ho E.;
RT "Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish
RT (Danio rerio) development.";
RL PLoS ONE 12:e0183831-e0183831(2017).
RN [9] {ECO:0000313|RefSeq:NP_001124249.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; CABZ01078991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC163862; AAI63862.1; -; mRNA.
DR RefSeq; NP_001124249.1; NM_001130777.1.
DR STRING; 7955.ENSDARP00000076900; -.
DR PaxDb; 7955-ENSDARP00000076900; -.
DR Ensembl; ENSDART00000082465.6; ENSDARP00000076900.5; ENSDARG00000059361.6.
DR GeneID; 562762; -.
DR AGR; ZFIN:ZDB-GENE-060315-8; -.
DR CTD; 55630; -.
DR ZFIN; ZDB-GENE-060315-8; slc39a4.
DR eggNOG; KOG2693; Eukaryota.
DR HOGENOM; CLU_015114_9_0_1; -.
DR OMA; EQWISAV; -.
DR OrthoDB; 5488029at2759; -.
DR TreeFam; TF318470; -.
DR Proteomes; UP000000437; Chromosome 19.
DR Bgee; ENSDARG00000059361; Expressed in swim bladder and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:ZFIN.
DR GO; GO:0006829; P:zinc ion transport; ISS:ZFIN.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF21; ZINC TRANSPORTER ZIP4; 1.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 60..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 149 AA; 15975 MW; BB65C7B2A474A7A0 CRC64;
MITIGDGIHN FADGLAIGAA FSISWRSGLA TSLAVLCHEL PHELGDFAVL LHCGVSVKRA
LLLNFGSSLT SFIGLYIALS VSTDSAAEQW ISAVTAGLFL YVGLADMLPT LIHVDSRRPW
LIFTLQNLGL LSGWGILLLL SFYEDQIGL
//
