GenomeNet

Database: UniProt
Entry: B3FFP4_MELME
LinkDB: B3FFP4_MELME
Original site: B3FFP4_MELME 
ID   B3FFP4_MELME            Unreviewed;       182 AA.
AC   B3FFP4;
DT   22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:ABV56961.1};
OS   Meles meles (Eurasian badger).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Melinae; Meles.
OX   NCBI_TaxID=9662 {ECO:0000313|EMBL:ABV56961.1};
RN   [1] {ECO:0000313|EMBL:ABV56961.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Koepfli K.-P.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABV56961.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18275614; DOI=10.1186/1741-7007-6-10;
RA   Koepfli K.P., Deere K.A., Slater G.J., Begg C., Begg K., Grassman L.,
RA   Lucherini M., Veron G., Wayne R.K.;
RT   "Multigene phylogeny of the Mustelidae: resolving relationships, tempo and
RT   biogeographic history of a mammalian adaptive radiation.";
RL   BMC Biol. 6:10-10(2008).
CC   -!- FUNCTION: During development, promotes the survival and differentiation
CC       of selected neuronal populations of the peripheral and central nervous
CC       systems. Participates in axonal growth, pathfinding and in the
CC       modulation of dendritic growth and morphology. Major regulator of
CC       synaptic transmission and plasticity at adult synapses in many regions
CC       of the CNS. {ECO:0000256|RuleBase:RU364086}.
CC   -!- FUNCTION: Important signaling molecule that activates signaling
CC       cascades downstream of NTRK2 (By similarity). During development,
CC       promotes the survival and differentiation of selected neuronal
CC       populations of the peripheral and central nervous systems. Participates
CC       in axonal growth, pathfinding and in the modulation of dendritic growth
CC       and morphology. Major regulator of synaptic transmission and plasticity
CC       at adult synapses in many regions of the CNS. The versatility of BDNF
CC       is emphasized by its contribution to a range of adaptive neuronal
CC       responses including long-term potentiation (LTP), long-term depression
CC       (LTD), certain forms of short-term synaptic plasticity, as well as
CC       homeostatic regulation of intrinsic neuronal excitability.
CC       {ECO:0000256|ARBA:ARBA00025383}.
CC   -!- SUBUNIT: Monomers and homodimers (By similarity). Binds to NTRK2/TRKB.
CC       Can form heterodimers with other neurotrophin family members, such as
CC       NTF3 and NTF4 (in vitro), but the physiological relevance of this is
CC       not clear (By similarity). BDNF precursor form: interacts with the
CC       heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower
CC       affinity for the heterodimer formed by NGFR and SORCS2.
CC       {ECO:0000256|ARBA:ARBA00025882}.
CC   -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
CC       {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EF987640; ABV56961.1; -; Genomic_DNA.
DR   AlphaFoldDB; B3FFP4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          119..182
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABV56961.1"
FT   NON_TER         182
FT                   /evidence="ECO:0000313|EMBL:ABV56961.1"
SQ   SEQUENCE   182 AA;  20165 MW;  50AFB5B01D4B7ABD CRC64;
     CMKAAPMKEA NVRGQGSLAY PGVRTHGTLE SMNGPKAGSR GLTSLADTFE HVIEELLDED
     QKVRPNQENN KDADLYTSRV MLSSQVPLEP PLLFLLEEYK NYLDAANMSM RVRRHSDPAR
     RGELSVCDSI SEWVTAADKK TAVDMSGGTV TVLEKVPVSK GQLKQYFYET KCNPMGYTKE
     GC
//
DBGET integrated database retrieval system