ID B3GJB5_9HIV1 Unreviewed; 390 AA.
AC B3GJB5;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ACD80599.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ACD80599.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACD80599.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACD80599.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=21158SASA4100XXxxxxxiDDDD1ccLK39XXXX
RC {ECO:0000313|EMBL:ACD80599.1};
RA Rousseau C.M., Daniels M.G., Carlson J.M., Kadie C., Crawford H.,
RA Prendergast A., Matthews P., Payne R., Rolland M., Raugi D.N., Maust B.S.,
RA Learn G.H., Nickle D.C., Coovadia H., Ndung'u T., Frahm N., Brander C.,
RA Walker B.D., Goulder P.J.R., Bhattacharya T., Heckerman D.E., Korber B.T.,
RA Mullins J.I.;
RT "HLA Class-I Driven Evolution of Human Immunodeficiency Virus Type 1
RT Subtype C Proteome: Immune Escape and Viral Load.";
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endohydrolysis of RNA in RNA/DNA hybrids. Three different
CC cleavage modes: 1. sequence-specific internal cleavage of RNA. Human
CC immunodeficiency virus type 1 and Moloney murine leukemia virus
CC enzymes prefer to cleave the RNA strand one nucleotide away from the
CC RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides
CC from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides
CC away from the primer terminus.; EC=3.1.26.13;
CC Evidence={ECO:0000256|ARBA:ARBA00023415};
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DR EMBL; EU698852; ACD80599.1; -; Genomic_DNA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 3.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR010659; RVT_connect.
DR InterPro; IPR010661; RVT_thumb.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF5; RIBONUCLEASE H; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF06815; RVT_connect; 1.
DR Pfam; PF06817; RVT_thumb; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..90
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 290..390
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACD80599.1"
FT NON_TER 390
FT /evidence="ECO:0000313|EMBL:ACD80599.1"
SQ SEQUENCE 390 AA; 45254 MW; 7A3A899711A5A819 CRC64;
QYNVLPQGWK GSPAIFQSSM TKILEPFRAK NPEIVIYQYM DDLYVGSDLE IGQHRAKIEE
LRTHLLKWGL TTPDKKHQKE PPFLWMGYEL HPDKWTVQPI QLPEKDSWTV NDIQKLVGKL
NWASQIYAGI KVRQLCKLLR GTKALTDIVP LTEEAELELA ENREILKEPV HGVYYDPSKD
LIAEIQKQGD DQWTYQIYQE PFKNLKTGKY AKMRTAHTND VKQLTEAVQK IALESIVIWG
KTPKFRLPIQ KETWEIWWTD YWQATWIPEW EFVNTPPLVK LWYQLEKEPI IGAETFYVDG
AANRETKLGK AGYVTDRGRQ KIISLAETTN QKTELQAIQL ALQDSGSEVN IVTDSQYALG
IIQAQPDKSE SELVNQIIEQ LIRKERVYLS
//
