ID B3KWI4_HUMAN Unreviewed; 581 AA.
AC B3KWI4;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=cDNA FLJ43122 fis, clone CTONG3003737, highly similar to Leucine-rich repeat-containing protein 15 {ECO:0000313|EMBL:BAG54146.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG54146.1};
RN [1] {ECO:0000313|EMBL:BAG54146.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Tongue {ECO:0000313|EMBL:BAG54146.1};
RA Kanehori K., Ishibashi T., Chiba Y., Fujimori K., Hiraoka S., Tanai H.,
RA Watanabe S., Ishida S., Ono Y., Hotuta T., Watanabe M., Sugiyama T.,
RA Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y.,
RA Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Matsuo K., Nakamura Y.,
RA Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Takahashi-Fujii A.,
RA Oshima A., Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K.,
RA Masuho Y., Nagai K., Isogai T.;
RT "NEDO human cDNA sequencing project.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AK125112; BAG54146.1; -; mRNA.
DR RefSeq; NP_570843.2; NM_130830.4.
DR AlphaFoldDB; B3KWI4; -.
DR IntAct; B3KWI4; 1.
DR PeptideAtlas; B3KWI4; -.
DR DNASU; 131578; -.
DR GeneID; 131578; -.
DR KEGG; hsa:131578; -.
DR CTD; 131578; -.
DR PharmGKB; PA134956867; -.
DR OrthoDB; 5357459at2759; -.
DR BioGRID-ORCS; 131578; 35 hits in 1142 CRISPR screens.
DR GenomeRNAi; 131578; -.
DR Genevisible; B3KWI4; HS.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF210; CHAOPTIN-RELATED; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 5.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 14.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..581
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002790184"
FT TRANSMEM 539..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 489..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 581 AA; 64394 MW; F1116A01BE3C549B CRC64;
MPLKHYLLLL VGCQAWGAGL AYHGCPSECT CSRASQVECT GARIVAVPTP LPWNAMSLQI
LNTHITELNE SPFLNISALI ALRIEKNELS RITPGAFRNL GSLRYLSLAN NKLQVLPIGL
FQGLDSLESL LLSSNQLLQI QPAHFSQCSN LKELQLHGNH LEYIPDGAFD HLVGLTKLNL
GKNSLTHISP RVFQHLGNLQ VLRLYENRLT DIPMGTFDGL VNLQELALQQ NQIGLLSPGL
FHNNHNLQRL YLSNNHISQL PPSVFMQLPQ LNRLTLFGNS LKELSPGIFG PMPNLRELWL
YDNHISSLPD NVFSNLRQLQ VLILSRNQIS FISPGAFNGL TELRELSLHT NALQDLDGNV
FRMLANLQNI SLQNNRLRQL PGNIFANVNG LMAIQLQNNQ LENLPLGIFD HLGKLCELRL
YDNPWRCDSD ILPLRNWLLL NQPRLGTDTV PVCFSPANVR GQSLIIINVN VVVPSVHVPE
VPSYPETPWY PDTPSYPDTT SVSSTTELTS PVEDYTDLTT IQVTDDRSVW GMTQAQSGLA
IAAIVIGIVA LACSLAACVG CCCCKKRSQA VLMQMKAPNE C
//
