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Database: UniProt
Entry: B3KZ79_PLAKH
LinkDB: B3KZ79_PLAKH
Original site: B3KZ79_PLAKH 
ID   B3KZ79_PLAKH            Unreviewed;       976 AA.
AC   B3KZ79;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   05-JUL-2017, entry version 43.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=PKH_011150 {ECO:0000313|EMBL:CAQ37947.1};
OS   Plasmodium knowlesi (strain H).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5851 {ECO:0000313|EMBL:CAQ37947.1, ECO:0000313|Proteomes:UP000031513};
RN   [1] {ECO:0000313|EMBL:CAQ37947.1, ECO:0000313|Proteomes:UP000031513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H {ECO:0000313|EMBL:CAQ37947.1,
RC   ECO:0000313|Proteomes:UP000031513};
RA   Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA   Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA   Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA   Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA   Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N.,
RA   Lapp S., Marti M., Moule S., Meyer I.M., Ormond D., Peters N.,
RA   Sanders M., Sanders S., Sergeant T.J., Simmonds M., Smith F.,
RA   Squares R., Thurston S., Tivey A.R., Walker D., White B.,
RA   Zuiderwijk E., Churcher C., Quail M.A., Cowman A.F., Turner C.M.R.,
RA   Rajandream M.A., Kocken C.H.M., Thomas A.W., Newbold C.I.,
RA   Barrell B.G., Berriman M.;
RT   "The genome of Plasmodium knowlesi strain H, a zoonotic malaria
RT   parasite with host range from monkey to man.";
RL   Nature 455:799-803(2008).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AM910983; CAQ37947.1; -; Genomic_DNA.
DR   RefSeq; XP_002257611.1; XM_002257575.1.
DR   STRING; 5850.PKH_011150; -.
DR   EnsemblProtists; CAQ37947; CAQ37947; PKH_011150.
DR   GeneID; 7318469; -.
DR   KEGG; pkn:PKH_011150; -.
DR   EuPathDB; PlasmoDB:PKNH_0112000; -.
DR   InParanoid; B3KZ79; -.
DR   KO; K02154; -.
DR   Proteomes; UP000031513; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031513};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031513};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    476    501       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    522    542       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    609    630       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    665       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    703    726       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    912    932       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      319    346       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   976 AA;  112105 MW;  7202325851F9867B CRC64;
     MCRLSTYARS LPPQTMKHGT LVLPSDRARE YLDCLGKNVD IQFIDMNEKT MKRQYKKYIQ
     RIDDMERILR FLEENIRKLP NVKIKKSKID SFLEHDNVYE LDQVEESLNR LHVQFVRFCN
     NNKELVDERN NAIEEKHVIL TAMNQLNPGA TKNGNVSKRL PESTLPYDEV NDESISLQTN
     MMKDGISMMM FTNISGVIKT KDQESFSRTI FRALRGNTYT YFQSIDESGD SSSGGVMDGV
     NDMDEGVGGG GATTCMNNGS DDDVTDGGND MNNEKEKKNE PKSVFVVYCQ GSSQSNIYQK
     ILKICKAYDV KTYDWPKTYE QARQRLKELK EIITDKQKAL KAYEEYFINE IFVLINVVEP
     NKNSLIEEWK LFCKKERYIY NSLNCFEGSD ITLRCDCWFS ANDEEKIRHM LITKSSNDLV
     SALLLSDKVL TPNISPPTYI KTNKFTKSYQ SMVDTYGIPR YGEINPAIST IITFPFLFGI
     MYGDVGHGVC IFLFALFLIL INNRIKNKSK NEMVSMLLDG RYMLLLMGFF AIYAGVLYND
     FFSMPLNLFT SMFEVDRQVD SVTYYKRRQV MNEASGQMED ADPYIFGFDA KWLGAENELT
     YINSFKMKFS IIIGFLHMTF GVLMKGLNAL HYRRKMDFFF EFLPQLMMML SIIGYLVFLI
     IYKWVTPIGY GGYKKQGIIN TVINMYLMKD LTPDNQFYAH QGLVQAFLIA IFVLCIPLMF
     VCKPAIRTYH IMKEKKSRGS ISSRGGSYSH HEEKEMTHTF NHLVGVGNGV NSANPGNGTS
     SSPSLHKRSP NMTFGGTNNN REDDYLSPRR RNKPTDDEME AHLLSPTAPE DQEGMVESFG
     AGSIGEAHHE ENISEIWIEQ LIETIEFILG LISNTASYLR LWALSLAHQQ LSFVFFEQTI
     LNSLRKDSFM SVLINLIVFS QLFSILTIAV ILCMDTLECF LHSLRLQWVE FQNKFYKGDG
     IPFRPFNIKK VLSESD
//
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