ID   B3L276_PLAKH            Unreviewed;       909 AA.
AC   B3L276;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=OTU-like cysteine protease, putative {ECO:0000313|EMBL:CAA9987211.1};
GN   ORFNames=PKNH_0616100 {ECO:0000313|EMBL:CAA9987211.1};
OS   Plasmodium knowlesi (strain H).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5851 {ECO:0000313|EMBL:CAA9987211.1, ECO:0000313|Proteomes:UP000031513};
RN   [1] {ECO:0000313|EMBL:CAA9987211.1, ECO:0000313|Proteomes:UP000031513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H {ECO:0000313|EMBL:CAA9987211.1,
RC   ECO:0000313|Proteomes:UP000031513};
RA   Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA   Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA   Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA   Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA   Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S.,
RA   Marti M., Moule S., Meyer I.M., Ormond D., Peters N., Sanders M.,
RA   Sanders S., Sergeant T.J., Simmonds M., Smith F., Squares R., Thurston S.,
RA   Tivey A.R., Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A.,
RA   Cowman A.F., Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W.,
RA   Newbold C.I., Barrell B.G., Berriman M.;
RT   "The genome of Plasmodium knowlesi strain H, a zoonotic malaria parasite
RT   with host range from monkey to man.";
RL   Nature 455:799-803(2008).
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DR   EMBL; AM910988; CAA9987211.1; -; Genomic_DNA.
DR   RefSeq; XP_002261832.1; XM_002261796.1.
DR   AlphaFoldDB; B3L276; -.
DR   STRING; 5851.B3L276; -.
DR   EnsemblProtists; CAQ38995; CAQ38995; PKH_061570.
DR   GeneID; 7319642; -.
DR   KEGG; pkn:PKNH_0616100; -.
DR   VEuPathDB; PlasmoDB:PKNH_0616100; -.
DR   HOGENOM; CLU_306641_0_0_1; -.
DR   InParanoid; B3L276; -.
DR   OMA; DENHREY; -.
DR   OrthoDB; 691582at2759; -.
DR   PhylomeDB; B3L276; -.
DR   Proteomes; UP000031513; Chromosome 6.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd22771; OTU_plant_OTU7-like; 1.
DR   Gene3D; 3.90.70.80; -; 1.
DR   InterPro; IPR003323; OTU_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR12419; OTU DOMAIN CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12419:SF7; OTU DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF02338; OTU; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS50802; OTU; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:CAA9987211.1};
KW   Protease {ECO:0000313|EMBL:CAA9987211.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031513}.
FT   DOMAIN          53..176
FT                   /note="OTU"
FT                   /evidence="ECO:0000259|PROSITE:PS50802"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          711..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        718..738
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        742..777
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   909 AA;  104721 MW;  2701B594737FD50D CRC64;
     MIDEYRGNSQ KRKKAKEKKK KNDEEIKGVK EVDDGINYSL INDYHDSNFK KNFYIKSIRT
     DGNCLFRAVS DQLYNNEDNY KEIRRLVVDH LLRNEQKYQH FIEYDESYKS YIDRISLDGT
     WGGQLELQAV GELFNVNILI YQENECILEI KNHSDDEKCI QLHYASSEHY NSVRFKNRAL
     ENELKSIVEL REILNNKDDS ESTKTFYETT DNELTEDNEE DMCDNTGNEN NNVGEWIDEK
     EFTFNNSVEE EYLQYDCPQE NNRNNIFSLS DDETEPCSLD ILQNIYNGIK RKGMRSRSMP
     TINENFLYFF SKNHVNESMD SDSTIDVLNE RKGLDMRKPK KIENRKLNFL KYNYIGQRPD
     DLLSEYVPRA GTMRTAVTPI RGENKTIRIC YNKTFHKYLC LSKMMEVGNN QREEKVGEGL
     DLFNGNYMYS NGGGKACRRV AQGEAIQGKS FDKSEVNKSG SPTEGESRIP LKHLHSAGRQ
     GYISNFELEN NLSRTKKKTF ENFLKLYSEK ISYSRNSFCK SISTNDVKSS NEGGSADAIG
     STSEQANSEC LNYENARNLS LNKISSSNEE ITAASSYFDK EDSMSFEFGP HVYDKRVEIN
     YLATEDDEEV NKCILYKNGE EGKKFCYNLM SKSQEIFDII IDEEYVLSMN SSMLFSHSGN
     KHVGRGNCYK KRGVTEQEEI PPSMSNRGGA KISYPVASPC VLNSRASFSG SKAEGRRTTS
     QIDVKVGDDH DRARGGSNCR IRRRNHQGNC SSGEGSGDTS GYSHTDASSQ SRIGATPRGS
     LKSRDLFLKK KYLNKKFINM FSKDIHSKGL FHFLNADFLL TGDKVKYIIP FLFNSERMNI
     FKDKLNRKDF HFSDYVTFSF NLDEQKLRKK IECSKVLNEE FLIKEKHKYS KFTRGGNGKS
     ENRVKIISI
//