ID   B3L582_PLAKH            Unreviewed;       423 AA.
AC   B3L582;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=Protein disulfide-isomerase, putative {ECO:0000313|EMBL:CAA9988302.1};
GN   ORFNames=PKNH_0925500 {ECO:0000313|EMBL:CAA9988302.1};
OS   Plasmodium knowlesi (strain H).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5851 {ECO:0000313|EMBL:CAA9988302.1, ECO:0000313|Proteomes:UP000031513};
RN   [1] {ECO:0000313|EMBL:CAA9988302.1, ECO:0000313|Proteomes:UP000031513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H {ECO:0000313|EMBL:CAA9988302.1,
RC   ECO:0000313|Proteomes:UP000031513};
RA   Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA   Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA   Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA   Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA   Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S.,
RA   Marti M., Moule S., Meyer I.M., Ormond D., Peters N., Sanders M.,
RA   Sanders S., Sergeant T.J., Simmonds M., Smith F., Squares R., Thurston S.,
RA   Tivey A.R., Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A.,
RA   Cowman A.F., Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W.,
RA   Newbold C.I., Barrell B.G., Berriman M.;
RT   "The genome of Plasmodium knowlesi strain H, a zoonotic malaria parasite
RT   with host range from monkey to man.";
RL   Nature 455:799-803(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM910991; CAA9988302.1; -; Genomic_DNA.
DR   RefSeq; XP_002259280.1; XM_002259244.1.
DR   AlphaFoldDB; B3L582; -.
DR   STRING; 5851.B3L582; -.
DR   EnsemblProtists; CAQ40053; CAQ40053; PKH_092520.
DR   GeneID; 7320914; -.
DR   KEGG; pkn:PKNH_0925500; -.
DR   VEuPathDB; PlasmoDB:PKNH_0925500; -.
DR   HOGENOM; CLU_649705_0_0_1; -.
DR   InParanoid; B3L582; -.
DR   OMA; DARKYPQ; -.
DR   OrthoDB; 239925at2759; -.
DR   PhylomeDB; B3L582; -.
DR   Proteomes; UP000031513; Chromosome 9.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd02961; PDI_a_family; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 2.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR46426; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR   PANTHER; PTHR46426:SF1; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 2.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031513};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..423
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030165603"
FT   TRANSMEM        383..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          12..140
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
SQ   SEQUENCE   423 AA;  49788 MW;  296F27031FFE90DB CRC64;
     MMGNLLLWSS FLLFSLACSN SKLPYPQGDL LKIDADNVQT VFDTNEYWLV KFYAPQCVHC
     KRIWSTIMNV KIDVQSDDKR RVYFGEVNCD DTNGRRICEQ YDVLKIPQLK LFKGHELLST
     YSYTTNDERS IKKWINYVTT PVFLAVHSEE ELNSFQTEDN FFLTCSENLS DDLMKAAKLY
     SEECYFINIK NRELCDKLII KENHLHIRGV DDHATYDLNK IDFEELKSFM NKNRFPLVSK
     VDHHTFFNLR SSGNNMILLL LDLQKGISAH LSQFKHYAKR HKRLGEFIFA YIDGKYYEEN
     LELYGTDARK YPQIIVFSKR PHEYYFEDYF DLDHLDDVID QIMKGSIKPK TETFTKSTIL
     LTQLKKHINY IIEKAFKTDL TSFIGFICFI IMIIMTSVLV VHTIYKFINS PETAARAKEK
     KKN
//