ID B3LCD7_PLAKH Unreviewed; 1266 AA.
AC B3LCD7;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=GPI ethanolamine phosphate transferase 3, putative {ECO:0000313|EMBL:CAA9990933.1};
GN ORFNames=PKNH_1433600 {ECO:0000313|EMBL:CAA9990933.1};
OS Plasmodium knowlesi (strain H).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5851 {ECO:0000313|EMBL:CAA9990933.1, ECO:0000313|Proteomes:UP000031513};
RN [1] {ECO:0000313|EMBL:CAA9990933.1, ECO:0000313|Proteomes:UP000031513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H {ECO:0000313|EMBL:CAA9990933.1,
RC ECO:0000313|Proteomes:UP000031513};
RA Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S.,
RA Marti M., Moule S., Meyer I.M., Ormond D., Peters N., Sanders M.,
RA Sanders S., Sergeant T.J., Simmonds M., Smith F., Squares R., Thurston S.,
RA Tivey A.R., Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A.,
RA Cowman A.F., Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W.,
RA Newbold C.I., Barrell B.G., Berriman M.;
RT "The genome of Plasmodium knowlesi strain H, a zoonotic malaria parasite
RT with host range from monkey to man.";
RL Nature 455:799-803(2008).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AM910996; CAA9990933.1; -; Genomic_DNA.
DR RefSeq; XP_002262218.1; XM_002262182.1.
DR AlphaFoldDB; B3LCD7; -.
DR STRING; 5851.B3LCD7; -.
DR EnsemblProtists; CAQ42096; CAQ42096; PKH_143140.
DR GeneID; 7323112; -.
DR KEGG; pkn:PKNH_1433600; -.
DR VEuPathDB; PlasmoDB:PKNH_1433600; -.
DR HOGENOM; CLU_262182_0_0_1; -.
DR InParanoid; B3LCD7; -.
DR OMA; KYVWPIS; -.
DR OrthoDB; 5479199at2759; -.
DR PhylomeDB; B3LCD7; -.
DR Proteomes; UP000031513; Chromosome 14.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031513};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAA9990933.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 793..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 844..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 876..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 908..926
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 932..953
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 974..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 998..1017
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1112..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1153..1176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1197..1223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1235..1259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 450..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1266 AA; 150024 MW; 260099F1636115A2 CRC64;
MKDKVKYNRF GNFLSNHVLI FFLIFLLNLL IFISFINGFL FPREGITNKS EDLETFSRKV
FGDEYIESQK NKKDVHSIVN PPYDRIVVLL IDALRFDFTL YDPNYKKELE NDESVDEEEK
TSKEVRFFQN NMMNLHHMLK TEKDKTMLFL FQADAPTVTT SRLKSMVIGS IPNYLDLNEN
FSPSDDIQDN FIEQLYYNRK TVTAIGDDTL VKLTKNVSRK LVYESFNIFD LYELDNKSKN
HFYEEYPLDY WDLLYVHVLG VDHVGHVGKP NSRKMKSVLK DFDIFVNDII QKVKSEEKKK
TLFVLFGDHG QTRTGDHSGF SADETDSSLF IYSPLKFMPL DKNINNKSFI LYDKDNLDRT
NSDSLYEFST CGSDKDQCFV ESYKNYHSYL NDLNKDRTYF YDVRFTKQIN LVSTLSFLIG
STIPFCNVGN VIMDFIPKAY KDDAPSAPAS FRTSNYGEEG NESESNSSSG DPLGEDKSSE
KSKPNVPRNG DDENYSKLYH EVLNLHYIAE LNYANLWQIN RYLKEYETHY RVIKNEDYFF
IKNNWKHIEE EMVRFFQPNK KFLDIEEILT SEKEDYIKYI NKMRNLMDVT QKYFYVIFAA
KKPSFIVLCF IVNIFFLMIF NIFYLNSKLN CYYKSISTGT FILLLTIFFI VLLPLDMYNK
CLHLLVLPFL FILIVVGIFF SRNKYTDFFR FISYVKVSLV CSNLPDANLK KYTAIQPGDK
HSTYQEKTQY SKLGDHTKNN FLRKSFLFFK CLYIIIRRSI ALSINIVLPY IFNITKCIFT
VKKKIFKYLM NNNYFFFVFI WSSCELSFYY IFKERHCIHF LLIVYVVLSL FKCESFFSLH
LLRGLALLTV LVVNTAFSFT PGYFEHDMEK LYLKKSMLQM ALPISLYFFS TLFINCGSNK
LLKREIKIIT LLGWTVQFAL VLLYFLKINE QVIFWNPLGV YLTTFLLYLF IIFRKSSLIQ
EEKVQEPLQK VQEVCITLFL ILFSSLQLSL IAYSNTNLSV LVFFYTTLFC FYFFFLSTNN
LEENKDMNNI KIKWIEENKQ VHMFSNLDDE KKTVEIRNVN TWVKEKFDLK LVHQKCTLLD
KCKCLEETDA TQIQIYKLIK NLPFFSLSDT DFYLLAAILI KYTFFLTGQK FVVNSLPLTS
AYIGFNKYVW PISQVYIFIH IFFPMLFSLL FILYVFNMRK IKMLMYFKGV DIYNFYFYPL
INFFFKSIFL FCCKCLTALW VAFYLELHLM LYDYFLPNFL FLTSINLVFI VSSILMLSLT
KYIFLR
//
