ID KIBRA_DROAN Reviewed; 1271 AA.
AC B3LWS4;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 01-MAY-2013, entry version 28.
DE RecName: Full=Protein kibra;
GN Name=Kibra; ORFNames=GF18133;
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling
CC pathway, a signaling pathway that plays a pivotal role in organ
CC size control and tumor suppression by restricting proliferation
CC and promoting apoptosis. The core of this pathway is composed of a
CC kinase cascade wherein Hippo (Hpo), in complex with its regulatory
CC protein Salvador (Sav), phosphorylates and activates Warts (Wts)
CC in complex with its regulatory protein Mats, which in turn
CC phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra
CC acts synergistically along with Ex and Mer to regulate the Hippo
CC signaling pathway (By similarity).
CC -!- SUBUNIT: Forms a complex with Mer and Ex. Interacts (via domain WW
CC 1) with Ex (via RXPPXY motif). Interacts with Mer, Sav, Hpo and
CC Wts (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Apical cell
CC membrane (By similarity). Note=Localizes at the apical cortex of
CC epithelial cells and cytoplasmic, punctate (By similarity).
CC -!- SIMILARITY: Belongs to the WWC family. KIBRA subfamily.
CC -!- SIMILARITY: Contains 1 C2 domain.
CC -!- SIMILARITY: Contains 2 WW domains.
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DR EMBL; CH902617; EDV42712.1; -; Genomic_DNA.
DR RefSeq; XP_001954151.1; XM_001954115.1.
DR ProteinModelPortal; B3LWS4; -.
DR EnsemblMetazoa; FBtr0122833; FBpp0121325; FBgn0095151.
DR GeneID; 6500911; -.
DR KEGG; dan:Dana_GF18133; -.
DR FlyBase; FBgn0095151; Dana\GF18133.
DR eggNOG; COG5021; -.
DR InParanoid; B3LWS4; -.
DR KO; K16685; -.
DR OrthoDB; EOG408KPW; -.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035330; P:regulation of hippo signaling cascade; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR InterPro; IPR000008; C2_Ca-dep.
DR InterPro; IPR008973; C2_Ca/lipid-bd_dom_CaLB.
DR InterPro; IPR001202; WW_dom.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; C2_CaLB; 1.
DR SUPFAM; SSF51045; WW_Rsp5_WWP; 2.
DR PROSITE; PS50004; C2; FALSE_NEG.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 3: Inferred from homology;
KW Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Membrane;
KW Phosphoprotein; Repeat; Transcription; Transcription regulation.
FT CHAIN 1 1271 Protein kibra.
FT /FTId=PRO_0000392968.
FT DOMAIN 45 78 WW 1.
FT DOMAIN 92 125 WW 2.
FT DOMAIN 687 789 C2.
FT COILED 192 223 Potential.
FT COILED 326 454 Potential.
FT COILED 1039 1066 Potential.
FT COMPBIAS 4 40 Gln-rich.
FT COMPBIAS 181 187 Poly-Ser.
FT COMPBIAS 505 530 Gln-rich.
FT COMPBIAS 826 835 Poly-Ala.
FT COMPBIAS 886 892 Poly-Asp.
FT COMPBIAS 1156 1168 Poly-Glu.
SQ SEQUENCE 1271 AA; 142669 MW; D9EF46FF70F6117D CRC64;
MPNQSQHHLQ PHPHHLRPQQ QQQQQQQQQQ QQHHRQQQQQ NHSDFPLPDG WDIAKDFDGK
TYYIDHINKK TTWLDPRDCY TKPQTFEDCV GDELPMGWEE SYDPNIGLYY INHLAQSTQL
EDPRQEWKSV QEQMLSDYLS AAQDQLENKR EMFDVKQQRL LWAQEEYNHL KLAASRSSLC
SSSSSMSRHD PELLRADLML ARERVHQLKQ ELNHITNDIS YTERGMNTLY SVGEKINARQ
NGCYDIAEVQ AIREEMLKVH KSLVSGEKVR EELMRSLVQI KNELSRQQIS EENSDLASPF
DRVCVASQTD LCGSTGDNLN GGARFAEMAK TKLQYAEWRK HIKKLQQQLA DHVERIEPGQ
LESDKDRILL IQEKEKLLND LNSISLKSRS EEEKRVIQQT RNKLEEDLKE AYEANNTCVA
NRLRFHEEKQ LLLDKLQEAL KSTKLLEERL KSFSSESTFS ISSGSSLGSL STASSKSALS
FTDIYIDPFA VDSPIDVVDL RRRSQRLFQQ HQRLHPVHPG LQQQQQQQQQ SSEVSLSPRS
SLSMETPPAS PMKYNPGADP TTPALKEEPT YANALPAPPA YTAPPPVPVS GVRARPYDLD
STVLDCMMLE AKLQKLNLGT PLNLAAAPLS PISEKPSLLD LPQEMLSRSS STSNTRSVSA
AVSNESVAGD SGVFEASRAH LPRKELAQVQ IGLKYLKLEG VLVVSLERAN NLLALWTASA
DNSQVYLRAA LLPNSLTSIR TKALGDFQKP VFNDTFAVPI TLDKLLTKSL QVTVVTMTGQ
KEEIIGTVQI SMAEFNPEDS TLKWYNVLSS KFIPTFESLD LPSTSAAAAA VAVAASSSAS
NSIREESSDE STITSSQTST LTRNQAPPME LQAQIAEEQP EQDGSDDDDD DDEEEDDNNK
KIIREVAVGL MNSGCMLDTY LQNMKQEFAD KETNTDCAFL PEKSRGQSQM MDDRPVKRSQ
TFTPSAAVSK NRYNCRLNRS DSDSAMHCGV APHTFQRGAA ERRSLRFHTK APKSVTKLHH
THIPRTSLDL ELDLQAQHSK LYFLNDQIAK LQNLKEVLQK ACENKDPLIA AWAIENEEFQ
RLVARADPAK CPEERQLQKL LMKTAKEIHK LRKTKVPKGC PDLVSFKEKI TFFTRKGMSV
PELPSEFTLP EANPIEEEEE EEEEDEDEFY NAAETAIAIN TALVASNNRN KNLTDHLNRV
SNYAAPKPPT IPAPPAASPA APAGSNPPSA TPSTTPATQA TTTAVPVPAD DNNPEQQRYD
YVVDRTYGVE V
//
