ID TRET1_DROAN Reviewed; 866 AA.
AC B3MG58;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 2.
DT 01-MAY-2013, entry version 26.
DE RecName: Full=Facilitated trehalose transporter Tret1;
GN Name=Tret1; ORFNames=GF13114;
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Low-capacity facilitative transporter for trehalose.
CC Does not transport maltose, sucrose or lactose. Mediates the
CC bidirectional transfer of trehalose. Responsible for the transport
CC of trehalose synthesized in the fat body and the incorporation of
CC trehalose into other tissues that require a carbon source, thereby
CC regulating trehalose levels in the hemolymph (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC (By similarity).
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDV36753.1; Type=Erroneous gene model prediction;
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DR EMBL; CH902619; EDV36753.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001959931.1; XM_001959895.1.
DR GeneID; 6495957; -.
DR KEGG; dan:Dana_GF13114; -.
DR FlyBase; FBgn0090147; Dana\GF13114.
DR eggNOG; COG0477; -.
DR InParanoid; B3MG58; -.
DR KO; K14258; -.
DR OrthoDB; EOG40K6FC; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0015574; F:trehalose transmembrane transporter activity; ISS:UniProtKB.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR InterPro; IPR005828; Sub_transporter.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; MFS_gen_substrate_transporter; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Glycoprotein; Membrane;
KW Phosphoprotein; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1 866 Facilitated trehalose transporter Tret1.
FT /FTId=PRO_0000395542.
FT TOPO_DOM 1 399 Cytoplasmic (Potential).
FT TRANSMEM 400 420 Helical; Name=1; (Potential).
FT TOPO_DOM 421 449 Extracellular (Potential).
FT TRANSMEM 450 470 Helical; Name=2; (Potential).
FT TOPO_DOM 471 482 Cytoplasmic (Potential).
FT TRANSMEM 483 503 Helical; Name=3; (Potential).
FT TOPO_DOM 504 506 Extracellular (Potential).
FT TRANSMEM 507 527 Helical; Name=4; (Potential).
FT TOPO_DOM 528 533 Cytoplasmic (Potential).
FT TRANSMEM 534 554 Helical; Name=5; (Potential).
FT TOPO_DOM 555 561 Extracellular (Potential).
FT TRANSMEM 562 582 Helical; Name=6; (Potential).
FT TOPO_DOM 583 651 Cytoplasmic (Potential).
FT TRANSMEM 652 672 Helical; Name=7; (Potential).
FT TOPO_DOM 673 682 Extracellular (Potential).
FT TRANSMEM 683 703 Helical; Name=8; (Potential).
FT TOPO_DOM 704 709 Cytoplasmic (Potential).
FT TRANSMEM 710 730 Helical; Name=9; (Potential).
FT TOPO_DOM 731 749 Extracellular (Potential).
FT TRANSMEM 750 770 Helical; Name=10; (Potential).
FT TOPO_DOM 771 776 Cytoplasmic (Potential).
FT TRANSMEM 777 797 Helical; Name=11; (Potential).
FT TOPO_DOM 798 810 Extracellular (Potential).
FT TRANSMEM 811 831 Helical; Name=12; (Potential).
FT TOPO_DOM 832 866 Cytoplasmic (Potential).
FT COMPBIAS 3 20 Gly-rich.
FT MOD_RES 257 257 Phosphoserine (By similarity).
FT MOD_RES 258 258 Phosphoserine (By similarity).
FT MOD_RES 259 259 Phosphoserine (By similarity).
FT MOD_RES 329 329 Phosphoserine (By similarity).
FT MOD_RES 331 331 Phosphoserine (By similarity).
FT MOD_RES 854 854 Phosphoserine (By similarity).
FT MOD_RES 855 855 Phosphoserine (By similarity).
FT CARBOHYD 437 437 N-linked (GlcNAc...) (Potential).
SQ SEQUENCE 866 AA; 95862 MW; FAE9B03B4D4B0451 CRC64;
MSGRDNRGAG GGGGGGGGGG HQPLSSAMGK LKEKLTRVGD ELGYHRVESN LSTSNTATSL
DTILPEDPFL FPQVSPQRHP QSTVRTQRLL EDEPPLSFRP LLEDDDINEP PTQQLTTQQQ
RTPLRASGSL ELTPLPPPPT SLEIREHRDR QQRSAQVAAE ELQRSKQSLK GSRVSFERRD
TGNSNSNKQA ESSDEDSFEE RRTGFQQQKA TSVDHKGILK DLKHILANDN RRQFQAKKHV
SLDVKGTRFL QDLLKESSSE EEFHKTRREF QGRKHQSLDP RVTFKLDKVL QGSSTDSDEE
GDDAEHKRLI HRPKDITKPV IIDLKDLESE SDEDFHTSRQ HFQQQRSIST DSRKSRRLYE
MDEMGNKRGE NIRHAVPFVR QITEDGKPKL EVYRPTTNPI FIWTQVLAAL SVSLGSLVVG
FVSAYTSPAL VSMVDRNITS FEVTPQAASW VGGIMPLAGL AGGIAGGPFI EYLGRRNTIL
ATAVPFIVSS LLIACAVNVA MVLAGRFLAG FCVGIASLSL PVYLGETVQP EVRGTLGLLP
TAFGNIGILL CFVAGTYMDW SMLAFLGAAL PVPFLVLMFL IPETPRWFVS RGREERARKA
LSWLRGKEAD VEPELKGLMR SQADADRQGT QNTMLELLKR SNFKPLSISL GLMFFQQLSG
INAVIFYTVS IFKDAGSTID GNVCTIIVGV VNFLATFIAT LLIDRAGRKI LLYVSNIAMI
ITLFVLGGFF YCKAHGPDVS HLGWLPLSCF VIYILGFSLG FGPIPWLMMG EILPAKIRGS
AASVATAFNW TCTFVVTKTF QDMIDVMGAH GAFWLFGAIC FIGLFFVILY VPETQGKTLE
DIERKMMGRV RRMSSVANIK PLSFNM
//
