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Database: UniProt
Entry: B3MG58
LinkDB: B3MG58
Original site: B3MG58 
ID   TRET1_DROAN             Reviewed;         866 AA.
AC   B3MG58;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 2.
DT   16-APR-2014, entry version 31.
DE   RecName: Full=Facilitated trehalose transporter Tret1;
GN   Name=Tret1; ORFNames=GF13114;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Low-capacity facilitative transporter for trehalose.
CC       Does not transport maltose, sucrose or lactose. Mediates the
CC       bidirectional transfer of trehalose. Responsible for the transport
CC       of trehalose synthesized in the fat body and the incorporation of
CC       trehalose into other tissues that require a carbon source, thereby
CC       regulating trehalose levels in the hemolymph (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDV36753.1; Type=Erroneous gene model prediction;
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DR   EMBL; CH902619; EDV36753.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001959931.1; XM_001959895.1.
DR   STRING; 7217.FBpp0116306; -.
DR   GeneID; 6495957; -.
DR   KEGG; dan:Dana_GF13114; -.
DR   FlyBase; FBgn0090147; Dana\GF13114.
DR   eggNOG; COG0477; -.
DR   InParanoid; B3MG58; -.
DR   KO; K14258; -.
DR   OrthoDB; EOG7N8ZV9; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015574; F:trehalose transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015771; P:trehalose transport; ISS:UniProtKB.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR   InterPro; IPR005828; Sub_transporter.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00879; SP; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Glycoprotein; Membrane;
KW   Phosphoprotein; Sugar transport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    866       Facilitated trehalose transporter Tret1.
FT                                /FTId=PRO_0000395542.
FT   TOPO_DOM      1    399       Cytoplasmic (Potential).
FT   TRANSMEM    400    420       Helical; Name=1; (Potential).
FT   TOPO_DOM    421    449       Extracellular (Potential).
FT   TRANSMEM    450    470       Helical; Name=2; (Potential).
FT   TOPO_DOM    471    482       Cytoplasmic (Potential).
FT   TRANSMEM    483    503       Helical; Name=3; (Potential).
FT   TOPO_DOM    504    506       Extracellular (Potential).
FT   TRANSMEM    507    527       Helical; Name=4; (Potential).
FT   TOPO_DOM    528    533       Cytoplasmic (Potential).
FT   TRANSMEM    534    554       Helical; Name=5; (Potential).
FT   TOPO_DOM    555    561       Extracellular (Potential).
FT   TRANSMEM    562    582       Helical; Name=6; (Potential).
FT   TOPO_DOM    583    651       Cytoplasmic (Potential).
FT   TRANSMEM    652    672       Helical; Name=7; (Potential).
FT   TOPO_DOM    673    682       Extracellular (Potential).
FT   TRANSMEM    683    703       Helical; Name=8; (Potential).
FT   TOPO_DOM    704    709       Cytoplasmic (Potential).
FT   TRANSMEM    710    730       Helical; Name=9; (Potential).
FT   TOPO_DOM    731    749       Extracellular (Potential).
FT   TRANSMEM    750    770       Helical; Name=10; (Potential).
FT   TOPO_DOM    771    776       Cytoplasmic (Potential).
FT   TRANSMEM    777    797       Helical; Name=11; (Potential).
FT   TOPO_DOM    798    810       Extracellular (Potential).
FT   TRANSMEM    811    831       Helical; Name=12; (Potential).
FT   TOPO_DOM    832    866       Cytoplasmic (Potential).
FT   COMPBIAS      3     20       Gly-rich.
FT   MOD_RES     257    257       Phosphoserine (By similarity).
FT   MOD_RES     258    258       Phosphoserine (By similarity).
FT   MOD_RES     259    259       Phosphoserine (By similarity).
FT   MOD_RES     329    329       Phosphoserine (By similarity).
FT   MOD_RES     331    331       Phosphoserine (By similarity).
FT   MOD_RES     854    854       Phosphoserine (By similarity).
FT   MOD_RES     855    855       Phosphoserine (By similarity).
FT   CARBOHYD    437    437       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   866 AA;  95862 MW;  FAE9B03B4D4B0451 CRC64;
     MSGRDNRGAG GGGGGGGGGG HQPLSSAMGK LKEKLTRVGD ELGYHRVESN LSTSNTATSL
     DTILPEDPFL FPQVSPQRHP QSTVRTQRLL EDEPPLSFRP LLEDDDINEP PTQQLTTQQQ
     RTPLRASGSL ELTPLPPPPT SLEIREHRDR QQRSAQVAAE ELQRSKQSLK GSRVSFERRD
     TGNSNSNKQA ESSDEDSFEE RRTGFQQQKA TSVDHKGILK DLKHILANDN RRQFQAKKHV
     SLDVKGTRFL QDLLKESSSE EEFHKTRREF QGRKHQSLDP RVTFKLDKVL QGSSTDSDEE
     GDDAEHKRLI HRPKDITKPV IIDLKDLESE SDEDFHTSRQ HFQQQRSIST DSRKSRRLYE
     MDEMGNKRGE NIRHAVPFVR QITEDGKPKL EVYRPTTNPI FIWTQVLAAL SVSLGSLVVG
     FVSAYTSPAL VSMVDRNITS FEVTPQAASW VGGIMPLAGL AGGIAGGPFI EYLGRRNTIL
     ATAVPFIVSS LLIACAVNVA MVLAGRFLAG FCVGIASLSL PVYLGETVQP EVRGTLGLLP
     TAFGNIGILL CFVAGTYMDW SMLAFLGAAL PVPFLVLMFL IPETPRWFVS RGREERARKA
     LSWLRGKEAD VEPELKGLMR SQADADRQGT QNTMLELLKR SNFKPLSISL GLMFFQQLSG
     INAVIFYTVS IFKDAGSTID GNVCTIIVGV VNFLATFIAT LLIDRAGRKI LLYVSNIAMI
     ITLFVLGGFF YCKAHGPDVS HLGWLPLSCF VIYILGFSLG FGPIPWLMMG EILPAKIRGS
     AASVATAFNW TCTFVVTKTF QDMIDVMGAH GAFWLFGAIC FIGLFFVILY VPETQGKTLE
     DIERKMMGRV RRMSSVANIK PLSFNM
//
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