ID B3MGY8_DROAN Unreviewed; 1674 AA.
AC B3MGY8;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Uncharacterized protein, isoform A {ECO:0000313|EMBL:EDV37906.1};
DE SubName: Full=Uncharacterized protein, isoform B {ECO:0000313|EMBL:KPU77098.1};
DE SubName: Full=Uncharacterized protein, isoform C {ECO:0000313|EMBL:KPU77099.1};
GN Name=Dana\GF11183 {ECO:0000313|EMBL:EDV37906.1};
GN Synonyms=dana_GLEANR_11252 {ECO:0000313|EMBL:EDV37906.1};
GN ORFNames=GF11183 {ECO:0000313|EMBL:EDV37906.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV37906.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:EDV37906.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSC#14024-0371.13 {ECO:0000313|EMBL:EDV37906.1}, and Tucson
RC 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000313|EMBL:EDV37906.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14024-0371.13 {ECO:0000313|EMBL:EDV37906.1};
RX PubMed=18057021; DOI=10.1093/bioinformatics/btm542;
RA Zimin A.V., Smith D.R., Sutton G., Yorke J.A.;
RT "Assembly reconciliation.";
RL Bioinformatics 24:42-45(2008).
RN [3] {ECO:0000313|EMBL:EDV37906.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14024-0371.13 {ECO:0000313|EMBL:EDV37906.1};
RG FlyBase;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; CH902619; EDV37906.1; -; Genomic_DNA.
DR EMBL; CH902619; KPU77098.1; -; Genomic_DNA.
DR EMBL; CH902619; KPU77099.1; -; Genomic_DNA.
DR RefSeq; XP_001961084.1; XM_001961048.2.
DR RefSeq; XP_014762604.1; XM_014907118.1.
DR RefSeq; XP_014762605.1; XM_014907119.1.
DR SMR; B3MGY8; -.
DR STRING; 7217.B3MGY8; -.
DR EnsemblMetazoa; FBtr0115883; FBpp0114375; FBgn0088223.
DR EnsemblMetazoa; FBtr0381113; FBpp0341436; FBgn0088223.
DR EnsemblMetazoa; FBtr0388489; FBpp0348193; FBgn0088223.
DR GeneID; 6494047; -.
DR KEGG; dan:6494047; -.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_002489_0_0_1; -.
DR OMA; VNPCKVN; -.
DR OrthoDB; 3107655at2759; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:EnsemblMetazoa.
DR GO; GO:0005770; C:late endosome; IEA:EnsemblMetazoa.
DR GO; GO:0005886; C:plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:1990909; C:Wnt signalosome; IEA:EnsemblMetazoa.
DR GO; GO:0015026; F:coreceptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0042813; F:Wnt receptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:EnsemblMetazoa.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0090254; P:cell elongation involved in imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0001745; P:compound eye morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0035223; P:leg disc pattern formation; IEA:EnsemblMetazoa.
DR GO; GO:0007616; P:long-term memory; IEA:EnsemblMetazoa.
DR GO; GO:0007399; P:nervous system development; IEA:EnsemblMetazoa.
DR GO; GO:0048076; P:regulation of compound eye pigmentation; IEA:EnsemblMetazoa.
DR GO; GO:0007367; P:segment polarity determination; IEA:EnsemblMetazoa.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 9.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 11.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1451..1470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 182..224
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 225..270
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 271..312
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 360..398
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 446..488
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 489..531
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 532..576
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 577..619
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 667..704
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 753..795
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 796..838
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 839..880
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 881..924
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 972..1011
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 1272..1314
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1479..1500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1517..1674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1485..1500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1517..1545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1579..1613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1347..1362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1365..1377
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1372..1390
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1384..1399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1674 AA; 186842 MW; 41858B2D8645237C CRC64;
MALEPHTKST TIEPQFQCQY KATNVTKTRK CSNYNNAAAV GRHLAIGGFL LICFGISASW
QYKQVHGPSS SSLIASPPAS AFVNTPATLL FTTRHDIQVA NITRPTGGPQ IDVIVRDLAE
AMAIDFYYAK NLVCWTDCGR EIIECAHTNA SSLLPLSRAP KQTVISTGLD KPEGLAIDWF
TDKIYWTDGE KNRIEVATLD GRYQKVLFWT DLDQPRAVAV VPARRLLIWT DWGEYPKIER
ASMDGDPLSR MTLVKDNVFW PNGLAVDLKN ELIYWTDGKH HFIDVMRLDG GNRRTIVNNL
KYPFSVTFFD NRLYWTDWQR GSLNALDLKT RELKELIDTP KAPNSVRAWD PSLQPYEDNP
CAHNNGNCSH LCLLATNSQG YSCACPTGVK LVSPNTCANG SQEMLFVVQR TQISKISLDS
PDYTIFPLSV GKVKYAIAID YDPVEEYIYW SDVETFTIRR AHTDGTGVTD FVTSEVRHPD
GLALDWLARN LYWTDTSTDR IEVCRLDGSA RKVLIYEHLE EPRAIAVAPS LGWMFWSDWN
ERKPKVERAS LDGSERVVLV SENLGWPNGI ALDIEAKAIY WCDGKTDKIE VANMDGSGRR
VVISENLKHL FGLSILDDYL YWTDWQRRSI DRAHKITGNN RIVVVDQYPD LMGLKVTRLR
EVRGQNACAV RNGGCSHLCL NRPRDYVCRC AIDYELANDK RTCVVPAAFL LFSRQEHIGR
ISIEYNEGNH NDERIPFKDV RDAHALDVSV AERRIYWTDQ KSKCIFRAFL NGSYVQRIVD
SGLIGPDGIA VDWLGNNIYW SDAEAHRIEV ARLDGSSRKV LLWKLVEEPR SLVLEPKRGY
MYWTESPTDS IRRAAMDGSD LQTIVTGANH AAGLTFDQET RRLYWATQSR PAKIECADWD
GKRRQVLVGS DTDEPYAVSL YQDYVYWSDW NTGDIERVHK TTGQNRSLVH SGMTYITSLL
VFNDKRQTGV NPCKVNNGGC SHLCLAQPGR RGMTCACPTH YQLAKDGVSC IPPKNYIIFS
QRNSFGRLLP NTTDCPNIPL PVSGKNIRAV DYDPITHHIY WIEGRSHSIK RSLVNGTKVS
QLANSGQPFD LAIDIIGRLL FWTCSYSNSI NVTSFLGESV GVIDTGDSEK PRNIAVHAMK
RLLFWTDVGS HQAIIRARVD GNERMELAYK LEGVTALALD QQSDMIYYAH GKRIDVIDIN
GKNKKTLVSM HISQVINIAA LGGFVYWLDD KTGVERITVN GGSRSAELQR LPQITDIRAV
WTPDPRVLRN HTCLQSRTKC SHICIASGEG MGRSRDICSC PKHLMLLEDK ENCGAFPACG
PDHFTCAAPV SGIGEVNKDC IPASWRCDGQ KDCPDKSDEV GCPTCRADQF SCQSGECIDK
SLVCDGTTNC ANGHDEADCC KRPGEFQCPI NKLCISAELL CDGWENCADG ADESSEICLQ
RRMAPASDKR AFMILIGATM ITIFSIVYLL QFCRRSRTEP KDDQASDPLS PSTLSKSQRV
SKIASVADAV RMSTLNSRNS MNSYDRNHIT GASSSTTNGS SMVAYPINPP PSPATRSRRP
YRHYKIINQP PPPTPCSTDI CDESDSNYTS KSNSNNSNGG ATKHSSSSAA ACLQYGYDSE
PYPPPPTPRS HYHSDVRIVP ESSCPPSPSS RSSTYFSPLP PPPSPVQSPS RGFT
//
