ID B3ML60_DROAN Unreviewed; 1817 AA.
AC B3ML60;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=GTPase-activating protein CdGAPr {ECO:0008006|Google:ProtNLM};
GN Name=Dana\GF15474 {ECO:0000313|EMBL:EDV31678.1};
GN Synonyms=dana_GLEANR_16240 {ECO:0000313|EMBL:EDV31678.1};
GN ORFNames=GF15474 {ECO:0000313|EMBL:EDV31678.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV31678.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:EDV31678.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH902620; EDV31678.1; -; Genomic_DNA.
DR RefSeq; XP_001962457.1; XM_001962421.2.
DR SMR; B3ML60; -.
DR STRING; 7217.B3ML60; -.
DR EnsemblMetazoa; FBtr0120174; FBpp0118666; FBgn0092499.
DR GeneID; 6498282; -.
DR KEGG; dan:6498282; -.
DR eggNOG; KOG1449; Eukaryota.
DR HOGENOM; CLU_235685_0_0_1; -.
DR InParanoid; B3ML60; -.
DR OMA; HALQKDM; -.
DR OrthoDB; 2913909at2759; -.
DR PhylomeDB; B3ML60; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF10; GTPASE-ACTIVATING PROTEIN CDGAPR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 285..353
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 414..608
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 70..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1387..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1755..1803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..950
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1387..1404
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1423..1461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1781..1803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1817 AA; 201433 MW; 7D44AD776BF0906A CRC64;
MSEKVSTSLA AQLHSHALAT AEAGGSASAC HVGSAQPPLQ FEMDAPAAAI SAQLNFKIVP
ADSLPGLSHQ DMFSSMNSSQ ISNASTESSC SPPTQGGVPP PKPSRHMAVQ PLNSKSCRFP
KLEECAHFHY ERVQLGPLSV QLLDDKSEHL GSSIASQSIG GDLPHSSLRS FSPESCWFII
RVCPQRCEPF LIKRSFENMQ LLDEMLHRCV YDRKISGLRN MAELAAELPS EPDVEYAVAK
YLERFSMIAS DSLTCGTILT WLQLDNKGRR LPLADGETQR TINTPAVGAA YGVRRYQAQA
PDEINIEVGD MISVIDMPSP AESIWWRGKK SHLQKSLYEV GFFPQSCVAT IGDKVPRNFP
MPAPLVGHLD ASPTKPVLRK HGKLIAFFRS FILSRPSRRR LKQSGIYRER VFNCDLSEHL
LNSGQDIPMV LRSCAEFIEN YGVIDGIYRL SGITSNIQRL RRSFDEERVP DLGNPEMKKD
IHAVSSLLKM YFRELPNPLC TYQLYDNFVE AIQVKADEVD ERLRLMKETV LKLPPPHYRT
LKYLAEHLYK VSQHHERTGM TDKNLAIVWA PNLLRSPALE SGGVAALRGV GVQAVVTEYL
IRNCHNIFDA LEDQTARQNM VASAQGGELR LESLTDCESL LVEQREQDQS LGLVERPKSL
STGGAKLISL EEAQERHSRI EGGDLKQSLP ISMLTSASSN AASNIGSYIE VGGGPSSLPD
KYHTVLSAPR SRQKHKPDKT PSWKSIFTRS QRQGNPEAGP KVSTDAKDSV ASRVSFVQAA
HAHASKELTK HDKPKSIELL ETTSHEREPK PMDLCIRSNS IDSLRTVGHS RSVSHDSYFD
LLQSPQRGHM TTCPSRELSE LGLNFDREEP EMRIFSESES LVSSPRVGKE NVPPSSGCAT
RRIMRARPED FSSQTNSVNP SPKKQPRLNL LSPSSARTMP PPPPPATAPQ SSCGHEPAGA
ENCCKRYKLE DQLCDIQFID CGTPETVPST QQQFASVEVH PPPKPVRGGH SPLASPSTAA
SGSGSGSGSG SSSSTRYSYP SVQLGAKRKD QQAAKERFSY QGTFTHSVPK QEAPGLRSVH
ANNTNTVPLR KPRVDPSEDG HVKLTVGTPT TPSRSPRYSL LLCDTESSEN SSAVNTPQYD
MEPLMLASAM SGVSGVSSNM QQQLLLGLDA ASSYLGSSHE SLGQNFNNVQ EHRDMNALKR
ELSLDLQPVQ QRLPQPANRA ATLPVKEQLQ AAAAAAMCSS PNNSNFTDNT SQSVTPSEFG
YQHLQRQLSM HSLLATEDSS PVYEDFEQTP VKMVPTSPIR STISITYKSP EKEKKAPALL
ETNFDENIVY EQVKLFRNSV TEVNQMLHER SSLKQIDEEE HQQDGEAYKA AEMTQQLLQL
EQDQHLEEQQ VEEDDAEEDE QSQLLYENIE LRKPKTVYEN LRGEEMKLNT EEKPSSDRIE
LDSLDSLPDN MEQERDHQHS PSKSPSFSVK ELANKFESSP VEQLPSFDFA VRGGSMKKPN
ELSVPKAMPA PVPLKKLNSV GQKITRSLDE NAFVREFGGK QLQDLSSSTK LPEVLSEVNS
RRKSFDFTRP KTLNPPKRLP GMSITEEICH KEPITPTTEN RISLIQQNNV PKEQPFLPPA
GRKSVLTGVV LDRERIDKIK EERRQQLTQK YHGDTLKSRS RTELNAEDNN FQAAESLRIK
SKSRGDMHAL QKDMDMNLKQ MSRVAGGGSE STLHMAQELG LQRVRRISDE KNQNCDTSSG
VSATSLLSVR TAAQKYGSTT AKVPTNKFER GQPMPRERLQ RNSLAESSAG SNNREKISPQ
FSIRDVTAMF ESRSQNQ
//
