ID B3N075_DROAN Unreviewed; 4778 AA.
AC B3N075;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN Name=Dana\GF21799 {ECO:0000313|EMBL:EDV38279.2};
GN Synonyms=dana_GLEANR_5700 {ECO:0000313|EMBL:EDV38279.2};
GN ORFNames=GF21799 {ECO:0000313|EMBL:EDV38279.2};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV38279.2, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:EDV38279.2, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH902640; EDV38279.2; -; Genomic_DNA.
DR RefSeq; XP_001966960.2; XM_001966924.2.
DR SMR; B3N075; -.
DR STRING; 7217.B3N075; -.
DR EnsemblMetazoa; FBtr0390274; FBpp0349811; FBgn0098799.
DR GeneID; 6504470; -.
DR KEGG; dan:6504470; -.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_000085_1_0_1; -.
DR InParanoid; B3N075; -.
DR OrthoDB; 2876235at2759; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0040003; P:chitin-based cuticle development; IEA:EnsemblMetazoa.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0048082; P:regulation of adult chitin-containing cuticle pigmentation; IEA:EnsemblMetazoa.
DR GO; GO:0030100; P:regulation of endocytosis; IEA:EnsemblMetazoa.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00112; LDLa; 33.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 34.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF00057; Ldl_recept_a; 33.
DR Pfam; PF00058; Ldl_recept_b; 7.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 21.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00192; LDLa; 35.
DR SMART; SM00135; LY; 36.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 32.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 4.
DR PROSITE; PS01209; LDLRA_1; 20.
DR PROSITE; PS50068; LDLRA_2; 35.
DR PROSITE; PS51120; LDLRB; 13.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4597..4618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 457..495
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 672..715
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 861..903
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 991..1033
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1653..1695
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1698..1741
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2336..2379
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2380..2421
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2612..2652
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2700..2741
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 3256..3297
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 3435..3476
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3523..3566
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4172..4208
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 4359..4402
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4404..4447
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4546..4580
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4742..4778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4742..4756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4758..4778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 161..173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 168..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 225..240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 277..292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 317..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 337..349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 344..362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 356..371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 461..471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1166..1184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1199..1211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1206..1224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1218..1233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1238..1250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1245..1263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1298..1313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1338..1353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1382..1397
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1402..1414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1409..1427
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2835..2847
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2842..2860
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2876..2888
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2883..2901
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2895..2910
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2915..2927
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2922..2940
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3001..3013
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3008..3026
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3044..3056
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3051..3069
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3137..3149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3144..3162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3179..3191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3186..3204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3198..3213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3220..3232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3227..3245
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3714..3726
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3721..3739
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3733..3748
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3802..3820
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3886..3904
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3922..3934
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3929..3947
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3941..3956
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3961..3973
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3968..3986
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3980..3995
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4005..4017
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4012..4030
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4054..4072
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4099..4117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4111..4126
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4570..4579
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4778 AA; 531393 MW; D3001C0297ADC332 CRC64;
MNPTPVGIGF GFGRKPPNKA RMRSRWRPLS GGPVAATTLP LAMGDSPATN THTLTQLTHK
INNNNTSHPE QLQNDKNDDE ISRRRSSRAV HPQKSNYHPQ YHRLSGQVTT LAMLLVALVA
LNNLESLLAV RTEGPRNRHG PPGGSLGSTG GSNIGGINAE CPTDSFRCNN GKCISHHWVC
NYQKDCDDGE DEMQSCPPPE CETPQLNCGQ YVFNKTYCIP PHYRCDMIED CEDKSDEAQC
TYRKCQHTDV FCNSASGAAP AEGARLIGPC VPKEKRCDGY LDCRTGRDEE GCPGVACRLD
QFRCASGQKC IDVALKCNHR DDCGDNSDEQ GCNFPQCHHA QFRCSNALCI PYNFHCDGYH
DCADKSDEAN CTAIACPDNK FLCPRGGAQG TPKCILKSQL CDGKRDCEDG SDEETNCSIA
SCPALGCEFK CGPSLTGGVC YCKPGQSLSN DNRTCVDLDE CAEWGHCDQL CTNTLGSYTC
QCAQGYTLIN DSKCIAPDAS NLQLIFAHDR AVMRMLAHGS DPKILANATA AAGVTFHYAR
NTLYWSDIKT RKVQSLPLDP QNKAVSPFDQ TLPGTWAPVA LAVDWVGDKI YVADLVGQKI
DVFELSGQWH AVVLGSNLTS PADLALDPTA GLMFVADGGQ VLRAHMDGTH ARSIVSEAAY
KASGVTVDII GKRVFWCDSL LDYIESVDYE GAHRVMVLRG QQVPSPSRLA LFENRIYWTD
ATKQGIMSVD KFEGPASIQV TYKAKDIREP KGIIAVHALS QPRVSNPCGN NNGGCNHMCI
VTAVKGAPTG LGFRCACSTG YQLETDLKLC KPVSEFLMYS QQRFIKGKVL EPVIEGFSDA
IMPVVSRRAR FVGLDFDARD EFIYYSDVLQ DVIYRVHRNG TGREIVLASQ NEGVEGLAVD
WASKNLYYID SRKGTLNVLS TRNVTHRRTL LKNLKRPRAI VVHPNRGFIF FSEWDRPANI
TRANTDGSGL LVFKNVTLGW PNGLSIDFKE DRVYWCDALL DHVQHANLDG TDIKTVNSRL
VRHPFSIVIH NDWMYITDWR LDAIIRLHKL TGEQEEMMVR EPQTNRLYGV KVYSHEVQRI
ADTQPCHRNN GGCQKICFAV LIGGQNGTTT PGDDGAIVSP ASLGRLQARC SCPYGERLAE
DQRTCMPDPS AEPPVQPCPN SWDFTCNNQR CIPKSWVCDG DDDCLDNSDE EQNCTKPTCG
ANEFQCRSGR CIPQNFRCDQ ENDCGDNSDE MECGNVTCGT SQFACANGRC IPNMWKCDSE
NDCGDSSDEG DFCAEKTCAY FQFTCPRTGH CIPQSWVCDG DDDCFDKQDE KDCPPISCLA
NQFKCADLRQ CVEESYKCDG IPDCNDGSDE LGCPSMGPNQ CNLEKHFRCK STGFCIPIAW
HCDGSNDCSD HSDEQDCGQI TCAQNFFKCN NTNCVFKAYI CDGKDDCGDN SDEGAEHACV
PPPFKCPHGQ WQCPGVSERC VNITSVCDDT PDCPNGSDEG EGCDLAECEH QAGRCSNFCQ
KTPNGALCVC PPGSEIGEDG YTCIDTNECD PPGLCSQQCT NTKGSYFCSC TDGYILEPNK
HTCKAVNHTA AFLIISNRHS ILVADLKEQG LERVPIIVEN VVATASNMHT GTIFWSDMKL
KKISRLDRGM EPQEIITTGL DLVEGLAYDW IAQNLYWLDS KLNTIEVSAE NGSNRLVLVR
ENITQPRGMC IDPSPGARWI FWTDWGENPR VERIGMDGTM RKTIINTKIY WPNGLTLDIA
TKRVYFADSK LDFIDFCYYN GTGRQQVLAS SHYLLHPHSL SLFEDTLYWT DRQLNRVLSA
NKFRGKNQTV VSHLISQPLS IHVHHASLQP QHPNPCAASH CQHLCLLSPS APEGYSCKCK
PGFKLLSEGR CIEDEKPFLM VVKGTQIVDL PLKGGDARAG ALTPVIGIES STGLDFDRKG
ETLYWVQGRE EDEENCTIYT TPYGGGNKTL FLGPDSGIVG APYTIAFDWL GRNLYIGNRV
ASNIEAVRVD GKQRYRAIIL ANDGYPNSVS RPKQMALDPT DGKLFWIDEG VLEVPVKIGR
VDMNGQNPKV ILDDVPHPES LVVDIEKKQL YYSASNPGLI GVMDYNGDEH STIVMRDSHP
MAKPRSLGIL DHRLYYLDPV YERIVRVDLP HGDNPKTIVD NESDLRSMMI YQKRALLQHP
CQTNNGGCKH LCLPGLQATR SCACGIGYRK ENEINCVSYK TFAVVSQLDT IRGYSLADSS
EAMLPISGPG HHILHVDVLF REQWVYWAEY NRGYWNGIFR SRPNGTDLQH VVKLGIGSNG
IRGLTIDWVA GNLYFTNVYP HENYVEVCWL DGSNRKVLVK TTTDAPRELA VNPIKRLLYW
IDYGQHPRIG KALLDGSKWT PLVTSGISMP RDLTIDMQTH DIFWVDSKLD TIQKISYNGA
NRKVIRRDLP NPMGIAVYLN DVYWVDRNLM TVFKASKHSA NETATRVRTN LEKLRDIAIY
NINNQPTDDA NPCAHLGNGG CDQLCFSFPP DSGTTGPSGR NFRCDCATGK LSSDERKCET
VNEYLVFATR TEIRAVNLDP HSTEVPFTPL TNLTNVVGLD FDFAENHMLY TQIRPWAKIA
YTKANKPSHD DIKVVLNKGI NPEGIAYDWT QKKIYWTDSS NNSIYAMNLD GTELVMITRV
ERPRAIVLDP CNGTLFFTDW GRFGTSGKIF RTTMAGSLKR AIVDKDLSQP SGLAIDYDER
KLYWTDAVRE KIERSDLDGQ NRELLVAATI YPFAITVFRN YIYWTDLQLR GVYRAEKHTG
ANMVEMVKRL EDSPRDIRIY SSDRQKCTVN PCMINNGGCA QSCHPVANGK TECKCDDSTK
VVNEGRMCAP RNNTCEASKF YCKNGKCISR MWSCDGDDDC GDNSDEDPNY CAYHSCSPNE
FRCNNGRCIF KSWKCDHEND CKDESDEIGC TYPPCVDGEF TCGNGRCIPQ AQVCNGVNDC
KDNGTSDETL ERCPMNTTCP ANHLKCEKTN ICVEPYWLCD GDNDCGDNSD EDPLHCGQRT
CPTNSFRCPN HRCIPATWYC DGDDDCGDGA DEPPDYCKSE GRTCFGDLFT CDNGNCIPRI
YICDGDNDCL DNSDEDNRHQ CNDRKCDEET EFTCVENKSW QRAQCIPKKW ICDGDPDCVD
GADENTTLHN CATQQPCGED MFTCGNGRCI NKGWICDHDN DCGDGTDEGK FCNSKYKTCS
TQEFTCQNFK CIRNQYRCDG EDDCGDHSDE VGCKKDNVTC PQGQFACTNG QCIDYSLVCN
KYPDCADESD EPAHCNVDEC AKVEINQCGH KCVDTLTGYY CDCNEGYKLL ADGKACADVD
ECLEQPGACS QHCSNTPGGF YCKCDENHYE RQNDEHTCKR KDNIPPWLIF TNKYYVRNMS
VDGHQYNLMH QDLMNVVALD FDIREEYMYF CDVTAKTIFR AKYGSADDET PPEREAVIRH
DSHGLEGIAI DWVGRKLYWL DRHSKNLDVA ELDGTKRKTL RSGVVDPRAI VVHPGIGYLY
FTSWHLQAYI AKMGMDGSNF TTILNWNDGI AWPNALSIDY FTDRIYWADA HLDYIAYADL
EGRHRHTVMS GSKVPHVFAL SLFDDYIYWS DWNLKAIVRA NKFHGANYTV LRNTTHRPYD
LHINHPLRQL PYNNPCGTNN GECSHLCLIA PPPESTYLNI EGYFEEGAPI HKCACPNQFY
LARDMKTCIA NCTAGQHLCG GKDEKCIPWF WKCDGEKDCK DGSDEPATCA ARHCRAGTFQ
CKNTNCTPSA TICDGVDDCG DRSDEQNCDL PCPLSDFKCK SSGRCILDSW RCDGDADCKD
GSDEDPAVCY KRTCDPKTEF SCKNGRCIPQ LWMCDFDNDC GDDSDEPAYM CRQRNCTTGW
QRCPGQSNYR CIPKWLFCDG KDDCRDNSDE LPENCPKCNP ETDFKCGNNR CIPKQWMCDF
ADDCGDASDE NDAICKGRYR DCSESEFRCG NGKCISSRWQ CDHEDDCGDN SDEMHCEGYQ
CKNGTFQCAS GHCIASYFRC DGDRDCRDMS DEVGCPPRFP GGRYCPESRY QCNNNLCVSL
SDLCDGTDDC GDGSDEDPSV CSDFNCDTLR RFQCSNHRCV ARYQICDGVD NCGDGSDENN
MTLCASKQKP CDLYTQYQCA NKHCIERSQV CDFSDDCGDA SDELGCHHVS SCSEQNRGGC
QHHCHNLTDG GYICTCYPGY IIAPDNKKKC TDVDECLTRQ HTCSHQCHNL NGTYSCSCRE
GFHLTDGASG VCRAEKEDVI LVFANGQEIR GLDLQKREEF DVIAAEKRIE ALDYDAQQQI
VFWADSYDKT IKRSYMVNAI DGRAKIGFAQ DLNMKGGSKP TAVAVDWLAS NLYWTEMDRT
GSKPRGRVMV AKTDGRYRRS IVNAGLEVPT SIAVNPQLGR IYWSDAGSAP KIEVSWMDGS
KRRPLITEQI RHPAGLTIDY SQDHIIYWVD TKLNAIESMR ADGSRRKAIV KGDQLRHPVS
LDLFESNMFW MTRDTGELLR QDKFGRGVQV VLHQNLINPS GLKVYHDKRY NTSLPNPCDN
STCSHLCLLV PGGHRCACPD TSGPPPSHRS TAEVICDAAA EHPRPAPRIC PCQNGGLCKE
DAQGELVCEC LAEFRGDHCE TSTTGAFGHG GANVTAVVVP IMVILLVMMA AAGAWYVIRK
RPFGKLARMP AMTSSQSVTF RHGSNVEFSE SGFPGASAPG AGDVAPIEGY NLQTVNANKA
RDFANPMYDA VQSGTTADPG MGNGSGIYDV PGEPSGKGKA MGHHAGGSFT EPASAIIAPS
SITHKASPQL QLRTRELDPS ADTGKDTQFL VEEDKSEC
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