ID BOP1_DROER Reviewed; 784 AA.
AC B3NLK7;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN ORFNames=GG21824;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CH954179; EDV54982.1; -; Genomic_DNA.
DR RefSeq; XP_001974582.1; XM_001974546.2.
DR AlphaFoldDB; B3NLK7; -.
DR SMR; B3NLK7; -.
DR EnsemblMetazoa; FBtr0141878; FBpp0140370; FBgn0114002.
DR GeneID; 6546825; -.
DR KEGG; der:6546825; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_2_0_1; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 5472008at2759; -.
DR PhylomeDB; B3NLK7; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17605:SF0; RIBOSOME BIOGENESIS PROTEIN BOP1; 1.
DR PANTHER; PTHR17605; RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Repeat; Ribosome biogenesis; rRNA processing; WD repeat.
FT CHAIN 1..784
FT /note="Ribosome biogenesis protein BOP1 homolog"
FT /id="PRO_0000370395"
FT REPEAT 445..486
FT /note="WD 1"
FT REPEAT 488..526
FT /note="WD 2"
FT REPEAT 570..612
FT /note="WD 3"
FT REPEAT 615..653
FT /note="WD 4"
FT REPEAT 656..695
FT /note="WD 5"
FT REPEAT 699..738
FT /note="WD 6"
FT REPEAT 754..784
FT /note="WD 7"
FT REGION 1..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..110
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 90474 MW; A97170767861ED8B CRC64;
MTKKLALKRK GKESEPINKV VASSEASENE EEEEDLLQAV KDPGEDSTDD EGIDQEYHSD
SSEELQFESD EEGNYLGRKQ SSSAEEDEES SDEDDDGEEE SSDEEEVEDE EKDSKLKQSD
DKPSSSGAAS KKAPTTELSK RDTSKPEYQD SDTSDEEDIR NTVGNIPMHW YDEYKHIGYD
WDAKKIIKPP QGDQIDEFLR KIEDPDFWRT VKDPLTGQDV RLTDEDIALI KRIVSGRIPN
KDHEEYEPWI EWFTSEVEKM PIKNVPDHKR SFLPSVSEKK RVSRMVHALK MGWMKTTEEV
EREKQAKRGP KFYMLWETDT SREHMRRIHD PVSAPKRDLP GHAESYNPPP EYLFDAKETK
EWLKLKDEPH KRKLHFMPQK FKSLREVPAY SRYLRERFLR CLDLYLCPRA KRVKLNIDAE
YLIPKLPSPR DLQPFPTVES MVYRGHTDLV RSVSVEPKGE YLVSGSDDKT VKIWEIATGR
CIRTIETDEV VRCVAWCPNP KLSIIAVATG NRLLLVNPKV GDKVLVKKTD DLLAEAPSQD
VIESERIKTA VQWSNAEADE QEKGVRVVIT HFKPIRQVTW HGRGDYLATV MPEGANRSAL
IHQLSKRRSQ IPFSKSKGLI QFVLFHPVKP CFFVATQHNI RIYDLVKQEL VKKLLTNSKW
ISGMSIHPKG DNLLVSTYDK KMLWFDLDLS TKPYQTMRLH RNAVRSVAFH LRYPLFASGS
DDQAVIVSHG MVYNDLLQNP LIVPLKKLQT HEKRDEFGVL DVNWHPVQPW VFSTGADSTI
RLYT
//
