ID B3NRK7_DROER Unreviewed; 1681 AA.
AC B3NRK7;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Low-density lipoprotein receptor-related protein {ECO:0000256|PIRNR:PIRNR036314};
GN Name=Dere\GG22489 {ECO:0000313|EMBL:EDV56159.1};
GN ORFNames=Dere_GG22489 {ECO:0000313|EMBL:EDV56159.1};
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220 {ECO:0000313|EMBL:EDV56159.1};
RN [1] {ECO:0000313|EMBL:EDV56159.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSC#14021-0224.01 {ECO:0000313|EMBL:EDV56159.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000313|EMBL:EDV56159.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14021-0224.01 {ECO:0000313|EMBL:EDV56159.1};
RX PubMed=18057021; DOI=10.1093/bioinformatics/btm542;
RA Zimin A.V., Smith D.R., Sutton G., Yorke J.A.;
RT "Assembly reconciliation.";
RL Bioinformatics 24:42-45(2008).
RN [3] {ECO:0000313|EMBL:EDV56159.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14021-0224.01 {ECO:0000313|EMBL:EDV56159.1};
RG FlyBase;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|PIRNR:PIRNR036314}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; CH954179; EDV56159.1; -; Genomic_DNA.
DR EMBL; CH954179; KQS62733.1; -; Genomic_DNA.
DR RefSeq; XP_001975759.1; XM_001975723.2.
DR RefSeq; XP_015012459.1; XM_015156973.1.
DR EnsemblMetazoa; FBtr0406628; FBpp0365203; FBgn0114660.
DR EnsemblMetazoa; FBtr0412969; FBpp0371287; FBgn0114660.
DR GeneID; 6549641; -.
DR KEGG; der:6549641; -.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_002489_0_0_1; -.
DR OMA; VNPCKVN; -.
DR OrthoDB; 3107655at2759; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:EnsemblMetazoa.
DR GO; GO:0005770; C:late endosome; IEA:EnsemblMetazoa.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1990909; C:Wnt signalosome; IEA:EnsemblMetazoa.
DR GO; GO:0015026; F:coreceptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0042813; F:Wnt receptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0090254; P:cell elongation involved in imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0001745; P:compound eye morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0035223; P:leg disc pattern formation; IEA:EnsemblMetazoa.
DR GO; GO:0007616; P:long-term memory; IEA:EnsemblMetazoa.
DR GO; GO:0007399; P:nervous system development; IEA:EnsemblMetazoa.
DR GO; GO:0048076; P:regulation of compound eye pigmentation; IEA:EnsemblMetazoa.
DR GO; GO:0007367; P:segment polarity determination; IEA:EnsemblMetazoa.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR017049; LRP5/6.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF00058; Ldl_recept_b; 9.
DR PIRSF; PIRSF036314; LDL_recpt-rel_p5/6; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 11.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|PIRNR:PIRNR036314};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR036314};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR036314};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR036314};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR036314};
KW Wnt signaling pathway {ECO:0000256|PIRNR:PIRNR036314}.
FT TRANSMEM 1454..1473
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR036314"
FT REPEAT 185..227
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 228..273
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 274..315
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 363..401
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 449..491
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 492..534
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 535..579
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 580..622
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 670..707
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 756..798
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 799..841
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 842..883
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 884..927
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 975..1014
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 1275..1317
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1484..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1524..1681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1492..1507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1524..1552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1586..1620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1350..1365
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1368..1380
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1375..1393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1387..1402
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1681 AA; 187787 MW; 3EDE53E86B4E9246 CRC64;
MALEPYTKSA EIEPQLCQVI ENNEDVTTKA TKCAKCAKSN SGVDWRQMLI GFLLICFGIS
NSWQYKNVHM PSSSSLIASP PASAFVNTPA TLLFTTRHDI QVANITRPTG GPQIDVIVRD
LAEAMAIDFY YAKNLVCWTD SGREIIECAQ TNSSALQPLL RAPKQTVIST GLDKPEGLAI
DWYTDKIYWT DGEKNRIEVA TLDGRYQKVL FWTDLDQPRA VAVVPARKLL IWTDWGEYPK
IERASMDGDP LSRMTLVKEH VFWPNGLAVD LKNELIYWTD GKHHFIDVMR LDGSSRRTIV
NNLKYPFSLT FYDDRLYWTD WQRGSLNALD LQTRELKELI DTPKAPNSVR AWDPSLQPYE
DNPCAHNNGN CSHLCLLATN SQGFSCACPT GVKLISANTC ANGSQEMMFI VQRTQISKIS
LDSPDYTIFP LPLGKVKYAI AIDYDPVEEH IYWSDVETYT IKRAHADGSG VTDFVTSEVR
HPDGLALDWL ARNLYWTDTV TDRIEVCRLD GTARKVLIYE HLEEPRAIAV APSLGWMFWS
DWNERKPKVE RASLDGSERV VLVSENLGWP NGIALDIEAK AIYWCDGKTD KIEVANMDGS
GRRVVISDNL KHLFGLSILD DYLYWTDWQR RSIDRAHKIT GNNRIVVVDQ YPDLMGLKVT
RLREVRGQNA CAVRNGGCSH LCLNRPRDYV CRCAIDYELA NDKRTCVVPA AFLLFSRQEH
IGRISIEYNE GNHNDERIPF KDVRDAHALD VSVAERRIYW TDQKSKCIFR AFLNGSYVQR
IVDSGLIGPD GIAVDWLANN IYWSDAEARR IEVARLDGSS RRVLLWKGVE EPRSLVLEPR
RGYMYWTESP TDSIRRAAMD GSDLQTIVAG ANHAAGLTFD QETRRLYWAT QSRPAKIESA
DWDGKKRQIL VGSDMDEPYA VSLYQDYVYW SDWNTGDIER VHKTTGQNRS LVHSGMTYIT
SLLVFNDKRQ TGVNPCKVNN GGCSHLCLAQ PGRRGMTCAC PTHYQLAKDG VSCIPPRNYI
IFSQRNSFGR LLPNTTDCPN IPLPVSGKNI RAVDYDPITH HIYWIEGRSH SIKRSLANGT
KVSLLANSGQ PFDLAIDIIG RLLFWTCSQS NSINVTSFLG ESVGVIDTGD SEKPRNIAVH
AMKRLLFWTD VGSHQAIIRA RVDGNERVEL AYKLEGVTAL ALDQQSDMIY YAHGKRIDAI
DINGKNKKTL VSMHISQVIN IAALGGFVYW LDDKTGVERI TVNGERRSAE LQRLPQITDI
RAVWTPDPKV LRNHTCMHSR TKCSHICIAS GEGIARTRDV CSCPKHLMLL EDKENCGAFP
ACGPDHFTCA APVSGISDVN KDCIPASWRC DGQKDCPDKS DEVGCPTCRA DQFSCQSGEC
IDKSLVCDGT TNCANGHDEA DCCKRPGEFQ CPINKLCISA ALLCDGWENC ADGADESSDI
CQQRRMAPAT DKRAFMILIG ATMITIFSIV YLLQFCRTRI GKSRTEPKDD QATDPLSPST
LSKSQRVSKI ASVADAVRMS TLNSRNSMNS YDRNHITGAS SSTTNGSSMV AYPINPPPSP
ATRSRRPYRH YKIINQPPPP TPCSTDICDE SDSNYTSKSN SNNSNGGATK HSSSSAAACL
QYGYDSEPYP PPPTPRSHYH SDVRIVPESS CPPSPSSRSS TYFSPLPPPP SPVQSPSRGF
T
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