ID   B3RH49_CARRO            Unreviewed;      1058 AA.
AC   B3RH49;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Toll-like receptor {ECO:0000313|EMBL:ABK88278.1};
GN   Name=TLR {ECO:0000313|EMBL:ABK88278.1};
OS   Carcinoscorpius rotundicauda (Mangrove horseshoe crab) (Limulus
OS   rotundicauda).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Merostomata;
OC   Xiphosura; Limulidae; Carcinoscorpius.
OX   NCBI_TaxID=6848 {ECO:0000313|EMBL:ABK88278.1};
RN   [1] {ECO:0000313|EMBL:ABK88278.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Loh B.W.C., Ding J.L.;
RT   "Carcinoscorpius rotundicauda toll-like receptor.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   EMBL; DQ989556; ABK88278.1; -; mRNA.
DR   AlphaFoldDB; B3RH49; -.
DR   SMR; B3RH49; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00364; LRR_BAC; 10.
DR   SMART; SM00365; LRR_SD22; 6.
DR   SMART; SM00369; LRR_TYP; 14.
DR   SMART; SM00082; LRRCT; 2.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 3.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 7.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:ABK88278.1};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..1058
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002796578"
FT   TRANSMEM        800..821
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        828..846
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          853..988
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          1034..1058
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1058 AA;  122626 MW;  C164F07490057EB0 CRC64;
     MFEKQVLFCF FHIIFLTVIP TSHEFICRKD YDNNCSSVLC GETANAHYLI CLPAKVSKYI
     YFRQNIEYNY RIEYSLYKYL KVECYGSAPY KFAMFSELDV AEIDYLIFVM CPLPNINFKD
     LFHGLTVKKL IFERRTRGSV FVSLFKDLTS LESLNLSWNE ISFLPEGIFQ NLINIKSLQI
     SNNQFKTVPE DIFQPLSNLE NLDLGSNKLA RLPKYLFSNL SKLKRLYLYN NQLSFLPNDI
     FNNLNSLEVL ELSGNHFTEL PENIFSGLPK LRRLGLANNE FKTLPAGFFR ENSALEELKL
     SGNPSFKHFP DGLLERLINL KNLSINDCNI TRINVSFFSQ VSSLVEIKMR NNRLTYLPIG
     TFQNNSNLRN LQMMFNDLIS LPIGLFEKQF NLIKLNLFKN DIQKLEPGIF DMLMSVQEIN
     LGYNYIKYIN ETVFKMLKNL KTLILTGNQI TTLEKYNYLD NVINLKIIDL SKNNLTTFPD
     VSMVAATNVT LINLKYNHIS HLEIPLLASY DVRIFLQGNQ IRTVSVSNTQ RCYKNNITLS
     SSVEHISGSR VFFLQKNLFQ CDCCMLDFAD HLTNSFHDCD FTANFHGSNE LVCSGPPKLA
     KKPITSILRA EFTCVVENNC PTLCSCFLRA SDNKVIVNCS GLYEDKLPLL FPENTSVLHF
     ENNSLTSLSE LSSEVHQTLT ELYLDNNLIS SIENWNFPPK LEVMSLRENY LNEFSIDMIK
     KVDKLSNFAF RLGNNPWNCD CQTVEFKSWL IEHLQNITDI DDIYCFAPIT LNGTLKKIPL
     VEMPDNVLCP NNDWSQKNTL ITVIIICVVL ALLLLTISVL YYRNKQTVIA YFYVHFFEVF
     PSFFTLDELE ENKLYDAFIS YCSSDSDVAV NILKELETKE PYFKLCVHDR DWLAGNAISS
     NIIYSIQNSK RIILILSKDF VESAWFHIEF HAAHYQTLED KVNRLIIVVT HNLPPKDSLD
     KDLQYLLSTK TYLLWKERWF WEKLRYAMPH RTSVQTIKNK RFYSNQSPSL ILKTGRNSIE
     KYNDNRKKIK QNTFVSGRSE SKNSEESTKK AQMLQTSI
//