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Database: UniProt
Entry: B3RK74_TRIAD
LinkDB: B3RK74_TRIAD
Original site: B3RK74_TRIAD 
ID   B3RK74_TRIAD            Unreviewed;      4949 AA.
AC   B3RK74;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   30-AUG-2017, entry version 68.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDV29875.1};
GN   ORFNames=TRIADDRAFT_52741 {ECO:0000313|EMBL:EDV29875.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV29875.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV29875.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B.,
RA   Dellaporta S.L., Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
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DR   EMBL; DS985241; EDV29875.1; -; Genomic_DNA.
DR   RefSeq; XP_002109077.1; XM_002109041.1.
DR   STRING; 10228.TriadP52741; -.
DR   EnsemblMetazoa; TriadT52741; TriadP52741; TriadG52741.
DR   GeneID; 6749570; -.
DR   KEGG; tad:TRIADDRAFT_52741; -.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   HOGENOM; HOG000231428; -.
DR   InParanoid; B3RK74; -.
DR   KO; K04962; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 3.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009022};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4374   4397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4506   4525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4556   4579       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4695   4721       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4744   4766       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4824   4843       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    148       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      155    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      247    297       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      316    376       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN     1100   1303       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4137   4172       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4174   4207       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4150   4161       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4185   4196       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED     3827   3850       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4949 AA;  562619 MW;  5F89BCA94FCEE3B2 CRC64;
     MESVLFYLLE IEDSITLSCN LANKYDSIQQ CRAILAAVGF GSRLCHLEHW INTERLPNMS
     LCVFILEQAM SVRALQERVV ATTSVTGSGS QAGRRTLLYG HAVLLRHTSS RKYLSCLSSC
     STSDKLAFDV GLEQHSQDES CWWTIHPASH HRSEGEKVRL GDNVIFVNVY SERYLYVSTS
     SNDLTVQASF QQTVWIVNPV MSGWALTKSR GYLNGGDVMR FIRGGDEYLS IPDDYKCGSE
     EQHWWSSAFI RWGQPFRLRN VISGQYIGMS DDKKHLCLLT SEAAKSEDSA LFCLQPSQDN
     ICIWDEKDEI NQGMGIPEIK FGDSLVFLRH YKTGLWVGPQ TTHGQRKQVI KEPFPFNIIA
     NKKSSDIKVH LLVEGHMDSA LSVTRGETEE IRTAHIIKVC SELLYQFLSS LGTGNSDDNN
     ELTIKHETED VDLKALEYIV FILNDLLGYF AWQKENLAHE VKQKHRVALK KRQELFQNEG
     VISLVLDVIG KICRDGDSKI TFQDVQNDSM WFKIHDLLFK LLAAMIRENH TNCTKLVEAI
     SLDWLLKRLE REHYIDGLLQ VLLCILTESS QSLSSVKEQH IKCMINLLDK HGRDNRILDM
     LSRICVCNGV AVRANQNLIC DNLLPKQKLL LQTKLVDQIT SVTANIYVGL FNGSAQHSKW
     YFEVAVDHVE PPSQDSVLCV ANKAASPISH LRIGWRNIKE VHHAEAGENW SGAGIGDSIF
     SYGFDGVNLW TNGRYLSVKN KPVSKAKRTM KKSGSMFCFI GQEKLGLNHS LNIAKDDLDD
     SMESSSVADF DSEDNSYNDV DNELNQSIQE DKLNEEAAKT APHQFRNGDV IGCYLDLGKQ
     SMTFSINGKL ITGEFRDISI DKQLFSPAIS MSSTVRCRLL LGGDYGEFNY NSRHYAPIYE
     GLDYGESVRV QESMVLGNPY RYEIIGPTAQ TEHSVFIPAP IDTTDVSLPT YLNDLRDKLA
     INMHDIWARN KIDAGWKFGR DRSDTLKVHP CLRPFTELSQ EEKEYDIKMA METLKSLVAL
     GYVINVVGEG KNVTKYQHLP DSKYLLSNGY KPHPLDLAQK EILNDHLEKV VEILAKNAHE
     VWAKDRIQQG WSYGLSKDGD RKRNPMLIPY EKLDEQSMKS NRDTARETIR TIIGFGCTID
     SPAVDLNVDS AKSLSRQVTD RAQNGSMRTF RVEKMYAVRR GKWYYEFHVN SPGMMRVGWC
     SEFFEAGKEV GGSSNSYSYD GFLARKWNHG SESFGKTWNK GDIVGCLLDL DTGKISFTLN
     GELLQDGMSS YAFEDIDVTV GYLPACSLAV GQSGRINFGH DPTSFKYFNI FGYQENYDPF
     GIVTSDSIPL WFASGIATFE TINDTHPTVK VTEWLMHTRD HPTLRVNSKP LRNSSDQSHK
     KFDLLRLNYP VNFTVPMVSS SRRKKSKFLG KYCFTLRIFK AQDPYEIYVG WISSKLHNYG
     NSFGDYSSRK ATMKGWKKQS DNSDDQLSST NTATQVQKLH NALPSYWSDT TRECYMARVS
     DLIAERGKRK ISSAVLGDIL IDCYANVNTG KLDFAFNGST CQFTHFDVEE GAKLYPAIYV
     RTPNNDKNLF QIEFRISKDC LPVCFTSNSH KLSQKSDATH LIKRPVLQAL KANTWCRMQT
     SSLVTVEKAL RHGYEIERED PSYSVMINIP EENRCINLQE LIEKEKLMYF HTHTLKLYSA
     LCSHGNIYVA DKIRYYVDEW QLMYCIQCFD LPDVVRVGYY DLLVSLHLEE HAKARLLTRG
     EYILPLKVEK ATPISFTSSK SDNTTVSNGS YSLSAAPLPG TVLSPHRKSG LTHDVSCTIE
     GAQAQSYSIQ HTSLDKPLFP LTPLKKHVFR TLQYHMQAIN RSRKETHRES RSLLLVPLLK
     VADCLLVMGV LDESDMELLL LLLDPQNFGS KMTVSQATLE VGLLRMTDLD EPVKLELCQL
     LDHLCDCQLR YRVESLVAYT SNFVDALQKE QRRRHNEIRN SQYPVAVTAR KTREFRIPPR
     TQLLMLLSFK TRETAESNPC SKDLQVSLRS YHKDVLKHCG KGNGIIKTTE SVAVIDRLKK
     SLWSSSKSTK NLQLTNANRA TLQEILAEVL IAWGKQSITD VALIKAIFRL WFRLHDGMAE
     LAEAITKTYT INDVGGDNVT NLLKALGSVR SLLTVRMGAT EEMQMTNGLK ELMNNTIFFQ
     HPDLMRVLGV HKTVMEVMVN VLGKEVEKQK GSQFQSWAGA TMDLSASTSP KPDGQSEITR
     KCLSPVMVAA CCKFLCFFCR TSQQNQRAMF EHMTYLLSHS DTSVTCTSMV GATPLDVAAA
     AMKDNLELVL ALRKHHLERV VSLLALTAPS TKIQSISDAV DMLTSGSTKA RSSSLLNRSN
     TWSNRMLRAR RNRIISKLEM MFDAGWEPKE GERYLDFLRH AIWVDNESVE ENASLVVRLL
     IRRPECLGPA LGSEGMGICQ AFREAISLSL STDDSATVNG KSRSEVGTQT LSFYSNLIDL
     AAKCSSANPI DSYVPSDIRV KAIAGTDHRK VALKTRDRIK AILQSLIPLR EIIGVLSLEF
     SLPVPNKDKN CMELETRGLI PSHKIAMVTF LDRVYGVDSQ EVLLRLLNYA FLPDLTNSIS
     LDEVPLSTEM ISAINRYISG SVMRLLTNHA HLFNGADSQP ELMAKTIDVC YRLSKCSFLN
     AAGQDSVNGF LLAFTCELKP SLMIKSLRIL AHDMPVLIEE NSVGLSILAS HFERCGKYYN
     SSGGWCTLGT ASAEEKTLTM VLFTQLLGAL SKGSYSKKLF SCALSCLFSS ACSLSPDYVL
     SQPGQTISPA ASLHRSLSTD FEDIYIPQPV NTVNVILTDE LKHLIHSYAC NKHDIWAHKQ
     FTEGWSFGFE SDEYDKKDSL LLPYNLLSQK DKYHLNKYMN DCLRTILASG WSITSHGDIT
     KEELIPYRKS AVNTNVSQSP HGYCPAPLDV SSIELSAETE NIAAFLADNA HQLKQFEALE
     ASGKGAVILI PYHILPDEDK ERYLSQTRDF LRYMKLFKFE CTRADRCTSI FGDTLTQYFT
     TEKRFAFCLL QSIIGYTRPI EYELKQRKSP TDPVANTDFY AKVCIPLVQH YFEIHQSYFI
     ATENQQQTVY GAATAREKKM VATLFYKLAM IARNDCNLFG SPAIVVDCIQ VIVTVLDIGA
     LIFHGFQDSV SNLQKLLLTA AEDLNNVVIS YESKLMRYIF DVLLPILCSL FRQIFKYDVN
     GIFSYDKVKT ACFGIINSLY RLGCNDKIRD QKHLADIGNC LNLISASFTM PFLELNHTTV
     NLSLFVRPIS SDPFDIDVLA AESKHLSHHY NDINIGTNHG GNLAKSSNEQ SHNDNIRLSL
     SESEISNSYA LPTIDESPEI QSHSNLPHLN ELLNMVDDYV YSNCGFKKSS YITDVILPML
     CSYISHWICI NGRNRYTNST TTTDEGSKVN ENYANFLLGH ILRIINTNFV THDIPTIYRI
     GDYALPLIKH CSASLLDTHF LPVTKKLTDF AIDLYRREDR LTKVADYDAQ DEVDVMEDYI
     KLAQNVRTFY PMLIKLTDRH KQTWITGCNK TGEELFRYVA DMFSCWHLSQ NFRREEQIYN
     SSTMGKSNSD LITQLNESVF QTFQKVGRSR FTSYNLFQES SNGNQSNSSL VIVCVRKLLA
     VGLNFINLAQ RQLMHEAKSK LIQKETDSDV LFYVINKVRK MGDESRWAKR IVTSSAALIL
     GLSFDDVQKE LALKIMEYSR VLHRLHIVDN PQKTITKSWK KILSQQRKRA IMKCFTRVPL
     YNLPKYRAVN VFIDVYRELW LSGEKCDGNA LVETLTSIKV DEDNPLESDP LSQLVLTICR
     DASNHEGDFN ADSELYKIYA DIMSESCIKF SEEDDDDDVE DGSASTFEES ERAKRRLDQQ
     QSRLAERNAA QMVLILLTES NGVVSPTILS ILRLGISLLR GGNQNVQEIM LKYLQSTRNV
     NFFTSLAKLT TSCSVLDLDT YERSAKAEIL GLGFSDVAAG SAIHNIEFIC SLFRFLQLLC
     EGHNLKFQDY LRTQAGNTTT VNIIVCTVDY LLRLQESISD FYWHYSSKEI IDIQGRENFS
     KAIRVAKQVF RTLTEYIQGP CVANQFTMSN SRLWDAVGGF WHVFACLQMK LSKETCHLEL
     LRELLKLHSE MVIMLLSMLE GSNANSGSIA KQLMETIIDS SEYIEMILKF FNMFLKLNDL
     GSSKSFKEFD IDGDGWISPS EFQKAMEQHK IYSSTEIDYL LKCADTNHDG KLDYMEFTER
     FQRPAQEIGF NLAVLIANLT DHVPDDPRLA HLEDLISGIM TYFESSLGRI EILGPSQRIE
     RVYFEIKTEH IDQWQKPQIQ DSKRTFLRDV VTNGNADKEK LENFVGFCED TIFEMQYGAR
     ISGTAKAEQI QRALEKRERD FDVPSPKPFL SSIRKKLSWK TIKNSVSPLA FLKLMLFCVI
     LPISFSARFL MLLWIWINHT LNFSNLAKKD TKASRVEFIF PHLQKFKSLF SFTDVRKRSK
     AISFLLTHLA NFTIKSFSNI MGSSSENVMI EFDWDNEEDG EGKHSYKPKI AAAKQTILSL
     FARSYYASRI IALLIAFGIN IILLFCKVTP VTEKNETLSS LGNSIILDSS NNYLDLALII
     LPILHLLASI ATLIAYWNLK VPLAIFKREK EIARKLEFDG YWVTKSRSQD YRDWWDGIVI
     NCGSFPSMYW DKFIKRKVRD KYSEHDNDYH RITQILNIED DENASEKGRI QKMAELLDLK
     YWIWRIGVIC TDRNFIYLLF YLLFSLLGNC LNNFFFAVHL IDFGFGNKTL STVLQSVTHH
     GRQLIMTLLM MAVVIYIYAV VAFNFFRQYY SREIRGRPEY KCDHMFTCFM FHLNSGLRSG
     GGIGDTIDPA DGDLYEYERI AFDFTFFFFV IVILLAIVQG LIIDAFGELR DKQESVKEDL
     ENKCFICGIG KEHFDKVPHG FDIHVEKEHN LANYMFFLLH LIEKPETEYT GQESYVWGLY
     QQRRWEFFPV GDCFRDQYQR EQQLLVNNT
//
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