ID B3RLK3_TRIAD Unreviewed; 485 AA.
AC B3RLK3;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN ORFNames=TRIADDRAFT_52033 {ECO:0000313|EMBL:EDV28791.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV28791.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV28791.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV28791.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
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DR EMBL; DS985241; EDV28791.1; -; Genomic_DNA.
DR RefSeq; XP_002107993.1; XM_002107957.1.
DR AlphaFoldDB; B3RLK3; -.
DR STRING; 10228.B3RLK3; -.
DR EnsemblMetazoa; TriadT52033; TriadP52033; TriadG52033.
DR GeneID; 6749208; -.
DR KEGG; tad:TRIADDRAFT_52033; -.
DR CTD; 6749208; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_563019_0_0_1; -.
DR InParanoid; B3RLK3; -.
DR OrthoDB; 5473909at2759; -.
DR PhylomeDB; B3RLK3; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF366; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 265..485
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 54999 MW; 710A28030F7C818D CRC64;
MKPPSDTPKW RMRQVWALSQ PPAIKKQVSR DSVNSDASLD ESWVYVERRS SSSGESTQTP
ATGTSLLDDQ SNTWYRRNHP SSPDSRSKRN QTVRTSPRLA QRDRHQSNTI PREDSNTSLN
LSLAENKNTN DDYRKSSFVT SSPTDSFIDV STIVDEAYAN DTSKGRSISR ASTSSSIAES
LTTNETKKLP RNSTFGSLES ELGYSNSNKS TESSLSRRDM VKPAGVKSIE SYGIVVDFPK
CPCPPDPDLP ELDLESITNI DLLRYPRELA KQITLIDHHL FRQVTVSECH KKFSSVSKKK
RHFDENNPIQ GFAERFNKLS QWVTASVLME KDIEVRAHIL CQFILTAKHC LQFANYNAVM
AIVVAGLGSS PIRRLEKTKA LISKEILAEY DNMEILMDPK SNYKEYRDAI KTAPTPAVPY
FGIYLKDLTF ATDGNPDYLR GGLINLTKRR YMYVVLEEMK RFQKEKYFFQ SWLRKGTVGC
SFVSL
//
