ID B3RQ00_TRIAD Unreviewed; 525 AA.
AC B3RQ00;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Xylulose kinase {ECO:0000256|RuleBase:RU367058};
DE EC=2.7.1.17 {ECO:0000256|RuleBase:RU367058};
GN ORFNames=TRIADDRAFT_53727 {ECO:0000313|EMBL:EDV28272.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV28272.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV28272.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV28272.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- FUNCTION: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate,
CC a molecule that may play an important role in the regulation of glucose
CC metabolism and lipogenesis. {ECO:0000256|RuleBase:RU367058}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+);
CC Xref=Rhea:RHEA:10964, ChEBI:CHEBI:15378, ChEBI:CHEBI:17140,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57737, ChEBI:CHEBI:456216;
CC EC=2.7.1.17; Evidence={ECO:0000256|RuleBase:RU367058};
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
CC {ECO:0000256|ARBA:ARBA00009156, ECO:0000256|RuleBase:RU367058}.
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DR EMBL; DS985242; EDV28272.1; -; Genomic_DNA.
DR RefSeq; XP_002110106.1; XM_002110070.1.
DR AlphaFoldDB; B3RQ00; -.
DR STRING; 10228.B3RQ00; -.
DR EnsemblMetazoa; TriadT53727; TriadP53727; TriadG53727.
DR GeneID; 6750779; -.
DR KEGG; tad:TRIADDRAFT_53727; -.
DR CTD; 6750779; -.
DR eggNOG; KOG2531; Eukaryota.
DR HOGENOM; CLU_016149_8_0_1; -.
DR InParanoid; B3RQ00; -.
DR OMA; STHFFNH; -.
DR OrthoDB; 1704034at2759; -.
DR PhylomeDB; B3RQ00; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004856; F:xylulokinase activity; IBA:GO_Central.
DR GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR GO; GO:0005997; P:xylulose metabolic process; IBA:GO_Central.
DR CDD; cd07776; FGGY_D-XK_euk; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR042024; D-XK_euk.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR PANTHER; PTHR10196; SUGAR KINASE; 1.
DR PANTHER; PTHR10196:SF57; XYLULOSE KINASE; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU367058};
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU367058};
KW Kinase {ECO:0000256|RuleBase:RU367058};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU367058};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transferase {ECO:0000256|RuleBase:RU367058};
KW Xylose metabolism {ECO:0000256|RuleBase:RU367058}.
FT DOMAIN 129..285
FT /note="Carbohydrate kinase FGGY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00370"
FT DOMAIN 293..478
FT /note="Carbohydrate kinase FGGY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02782"
SQ SEQUENCE 525 AA; 58113 MW; BCD57844CD5F7D3D CRC64;
MGDTSTYLGF DFSTQQLKAI AIDSKLTVIC QYNVIYDKEL SEFKTKGGVH KHPDRITVTS
PCLMWVKALD IILQKMKNDN FDFSSVVSIC GAGQQHGSVY WKKGAGEILN HLDAAQGTLA
SQLENCLALL NSPVWMDSST TKQCLQLERA FNGPQNLANV TGSKAYERFT GCQIAKIFQN
FPNIYQECER ISLVSSFGAS LFLGRYAAID YCDGSGMNLM DIFMKRYSDC ALQACAPNLK
ELLGDLVKPG TNLGCISSYM RDKYGFSSNC RVSAFTGDNP ASLVGMRLKQ GDLAISLGTS
DTVFIWLDNP QPALEGHIFC NPISSESFMA LLCFKNGSLT RESIKNELGI ETWEKFEELM
ADTPPGNNGN IGIYFKEMEI TPPKIGCYRY DCNGNEMQDF DLKTEVRALI EGQFMAKRMH
AENLGYDIGK CNRIIATGGA SSNKALLQVL SDIFNKPIYV QNISNSVSLG GAYMANFAIN
SELLEEWLLL RDSYRLAAEP NPATITAYSK LLESYRCLEA KIPSK
//
