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Database: UniProt
Entry: B3RSC0_TRIAD
LinkDB: B3RSC0_TRIAD
Original site: B3RSC0_TRIAD 
ID   B3RSC0_TRIAD            Unreviewed;       843 AA.
AC   B3RSC0;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   07-JUN-2017, entry version 50.
DE   RecName: Full=Non-lysosomal glucosylceramidase {ECO:0000256|PIRNR:PIRNR028944};
DE            Short=NLGase {ECO:0000256|PIRNR:PIRNR028944};
DE            EC=3.2.1.45 {ECO:0000256|PIRNR:PIRNR028944};
GN   ORFNames=TRIADDRAFT_54543 {ECO:0000313|EMBL:EDV27030.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV27030.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV27030.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B.,
RA   Dellaporta S.L., Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- FUNCTION: Non-lysosomal glucosylceramidase that catalyzes the
CC       conversion of glucosylceramide to free glucose and ceramide.
CC       {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- CATALYTIC ACTIVITY: D-glucosyl-N-acylsphingosine + H(2)O = D-
CC       glucose + N-acylsphingosine. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SIMILARITY: Belongs to the non-lysosomal glucosylceramidase
CC       family. {ECO:0000256|PIRNR:PIRNR028944}.
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DR   EMBL; DS985243; EDV27030.1; -; Genomic_DNA.
DR   RefSeq; XP_002111026.1; XM_002110990.1.
DR   ProteinModelPortal; B3RSC0; -.
DR   STRING; 10228.TriadP54543; -.
DR   EnsemblMetazoa; TriadT54543; TriadP54543; TriadG54543.
DR   GeneID; 6751699; -.
DR   KEGG; tad:TRIADDRAFT_54543; -.
DR   eggNOG; KOG2119; Eukaryota.
DR   eggNOG; COG4354; LUCA.
DR   HOGENOM; HOG000234168; -.
DR   InParanoid; B3RSC0; -.
DR   KO; K17108; -.
DR   OMA; HDYQDSS; -.
DR   OrthoDB; EOG091G01JK; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro.
DR   InterPro; IPR008928; 6-hairpin_glycosidase-like.
DR   InterPro; IPR014551; B_Glucosidase_GBA2-typ.
DR   InterPro; IPR006775; GH116_catalytic.
DR   InterPro; IPR024462; GH116_N.
DR   Pfam; PF04685; DUF608; 1.
DR   Pfam; PF12215; Glyco_hydr_116N; 1.
DR   PIRSF; PIRSF028944; Beta_gluc_GBA2; 1.
DR   SUPFAM; SSF48208; SSF48208; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009022};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR028944};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR028944};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR028944};
KW   Membrane {ECO:0000256|PIRNR:PIRNR028944};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT   DOMAIN       69    390       Glyco_hydr_116N. {ECO:0000259|Pfam:
FT                                PF12215}.
FT   DOMAIN      461    826       DUF608. {ECO:0000259|Pfam:PF04685}.
SQ   SEQUENCE   843 AA;  96505 MW;  D0417234459CDC3B CRC64;
     MAGHYGWKVN LDHKFKQDAF RFGDVRPKQV LVSLKMGLRY GMYILHNRFH SREPFIDLFG
     KRQVDRLYGV PIGGLGCGTI MRGWNGQFCR WQLRPGWYTY DIVHADQFTV SIRKNGEPSY
     QQVLSPCRPS SAQLGDWFWG YHGSQATYRA LYPRAWTTYN LPGQNVTLTC RQISPIIPHN
     YKDSCLPVGC FIWEIDNQSD DEIEVSIMFT FQNGDGSEHD SAGGHQNETF TRSSNENMNN
     SKISGVLLHH RASLQPCTFT ICAKECPETG DYPAVSVSNS VSFDPKGSGR EISRQLLSHG
     KLENSSNTKA TQSPVSKKGE IIGAAVATTA IVKPQGKAKM EFALTWDQPE VYFDAKEIKY
     RRRYTRFFNP NGSHRAADLA VYALQNVKSW EEKIDQWQSP ILENESYPDW YKSAIFNELY
     YMSDSGSIWA ETDGDEDDET NLASCLKEVP GKGKQIHKEY GRFAYLEGHE YLMYNTYDVH
     FYASFALAQL WPMIELSIQY DFAASIMHED PELRLIMWTG LRKPRKSYGF VPHDIGEPCD
     EPWKRINAYC ISDVQDWTDL NTKFVLQIYR DYCATGNLEF LKDMWPCAKH VMETAISQDT
     DGDGIIDNNG ADQTYDVWRM YGASAYCGGI FLAALYIMYK IADLIGCKED KAKYSKILLR
     GRDSFQQKLW NGDYYLYDSS KGNHSDSIMA DQMCGHWYLQ ACGLVNNNED DIFPKSQVDK
     ALRKVFDYNV MKFMNGTWGA VNGMKPNGEI DTSSVQSEEV WTGVTYALAA NLIQQGMIKE
     GFKVAEGMYD TTFNVMGLGF QTPEAYYKIN RYRCTGYMRP LSIWAIEWAF NHVFKKNTKK
     ITK
//
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